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Shivani Watak ¹, Swati S. Patil ¹

Affiliations
1 Department of Pharmacognosy and Phytochemistry, Prin. K.M. Kundnani College of Pharmacy, Cuffe Parade, Colaba, Mumbai, IN

Abstract

Background phenolic compound exhibit strong antioxidant properties but major drawback of phenolic compound is their poor bioavailability. Literature resources reveled that formation of complex of these phenolic compound with mineral will increase bioavailability and free radical scavenging activity. objective it was interesting to investigate their metal-chelating property, which stimulates our interest to evaluate Zn(II)-chelating ability and the effect of Zn(II) on its radical-scavenging activity The knowledge of those properties can be applied in future studies aimed at elucidating the mechanisms of anticancer activity Material and method Phenolic compounds such as Catechin, Curcumin and polyphenols from Trigonella foenum graecum extract chelate the divalent metal ions Zn²⁺in weakly acidic aqueous solution. Thus herbomineral complex was formed by the process of chelation. Formed complex was evaluated by Colorimetric assay, UV, IR, NMR and HPLC studies These studies may serve as a guide for the examination of metal chelation by polyphenols.

Keywords

Poly Phenols, Metal Chelation, Evaluation.

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Shivani Watak ¹, Swati S. Patil ¹

Affiliations
1 Prin. K.M. Kundnani College of Pharmacy, Cuffe Parade, Colaba, Mumbai, IN

Abstract

Phenolic compounds are metal chelator, it is interesting to investigate Their metal-chelating property, which stimulates our interest to evaluate Zn(II)- chelating ability and the effect of Zn(II) on its radical-scavenging activity by theoretical calculation. It was revealed that Phenolic compound could efficiently sequester Zn(II) and the Zn(II)-Phenolic compound complexes were more active than the parent compound in scavenging radicals by donating proton or electron. Therefore, Phenolic compounds are a multipotent agent, with the activities of scavenging ROS, blocking A aggregation and chelating metal ions.

Keywords

Metal Chelator, Antioxidant, Phenolic Compounds.

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