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Dash, Suvakanta
- Formulation and Statistical Optimisation of Fast Dissolving Tablets of Ambroxol Hydrochloride
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Authors
Affiliations
1 Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara-17, Assam, IN
1 Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara-17, Assam, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 181-189Abstract
The aim of the present study is to formulate and optimize fast dissolving tablets of Ambroxol hydrochloride using a 23 response surface methodology employing Design Expert-10.0. Sodium starch glycolate and Camphor were selected as independent variables while disintegration time (sec) and water absorption ratio (%) were considered as responses. The prepared tablets were evaluated for various evaluation parameters including hardness, thickness, friability, drug content uniformity, wetting time, water absorption ratio and disintegration time. The prepared optimized fast dissolving tablets of Ambroxol hydrochloride having above 2 responses-disintegration time(sec) and water absorption ratio of sec and %. The optimized batch having concentration of sodium starch glycolate and camphor was found within the standard limit of parameters-disintegration time (sec) and water absorption ratio(%). The direct compression method in this study is relatively simple and safe and a stable, effective and pleasant tasting fast dissolving tablets, which has a good balance over disintegration time and water absorption ratio, was formulated.Keywords
Ambroxol Hydrochloride, Sodium Starch Glycolate, Camphor, Statistical Optimization.- Formulation and In-Vitro Evaluation of Ethyl Cellulose Microspheres by Novel Quasiemulsification Method for Colonic Delivery of Metronidazole
Abstract Views :185 |
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Authors
Prasanta Kumar Choudhury
1,
Padala Narasimha Murthy
2,
Suvakanta Dash
3,
Rana Mazumder
4,
Dhruba Sankar Goswami
5
Affiliations
1 Department of Pharmaceutical Technology, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760002, Ganjam, Orissa, IN
2 Department of Pharmaceutical Technology, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760002, Ganjam, Orissa,, IN
3 Girjananda Choudhury Institute of Pharmaceutical Sciences, Guwahati, Assam, IN
4 Dept. of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah-711316, West Bengal, IN
5 Dept. of Pharmaceutics, S.D. College of Pharmacy, Barnala, Punjab, IN
1 Department of Pharmaceutical Technology, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760002, Ganjam, Orissa, IN
2 Department of Pharmaceutical Technology, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur-760002, Ganjam, Orissa,, IN
3 Girjananda Choudhury Institute of Pharmaceutical Sciences, Guwahati, Assam, IN
4 Dept. of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah-711316, West Bengal, IN
5 Dept. of Pharmaceutics, S.D. College of Pharmacy, Barnala, Punjab, IN