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Rajput, Suresh
- Synthesis, Characterization and Antimicrobial Activity of A 5(4-(4- Substituted)Aminobenzylidine)Thiazolidine-2,4-Dione Derivatives
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Authors
Affiliations
1 Ultra College of Pharmacy, Madurai (T.N), IN
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
1 Ultra College of Pharmacy, Madurai (T.N), IN
2 Rungta College of Pharmaceutical Sciences and Research, Bhilai (C.G), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 40-43Abstract
A novel 5(4-(4-substituted)Aminobenzylidine)thiazolidine-2,4-dione derivatives were synthesized and characterized by IR and H-NMR spectral analysis. Antibacterial and antifungal activities of the compounds were assessed by in vitro growth inhibitory activity against Escherichia coli, Staphylococcus aureus, Asperigillus niger, Candida albicans by using the disc diffusion method. Most of all compounds exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, while weak antifungal activity against Asperigillus niger and Candida albicans.