A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Goyat, Sumedha
- Phytochemistry and Pharmacology of Vitex negundo Linn.-A Review
Authors
1 Savitri Devi Memorial College of Pharmacy, Rajound, Kaithal, Haryana, IN
2 B. S. Anangpuria Institute of Pharmacy, Faridabad, Haryana, IN
3 Janta College of Pharmacy, Butana, Sonipat, Haryana, IN
4 Ganpati Institute of Pharmacy, Bilaspur, Yamuna Nagar, Haryana, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 249-255Abstract
Vitex negundo Linn. belongs to family Verbenaceae and is widely distributed in India and is found mostly in warmer zones and ascending to an altitude of 1500 metres in outer western Himalayas. The plant is distributed in various other countries like, Ceylon, Afghanistan, Tropical Africa, Madagascar, China, Philippines, Nepal, Bhutan, Pakistan, etc. Several chemical constituents like, pinene, limonene, linalool, camphene, farnesene, betulic acid, urosolic acid, vitexin, isovitexin, negundoside, etc., have been identified and isolated. Vitex negundo extracts shows anti-inflammatory and anti-androgenic activities. This plant also finds its use as a biopesticidal and for its anti-feedant activity. Studies have also been reported to demonstrate its ability as a mosquito repellent and an analgesic. The extracts of the plant shows the potential as an antidote for snake poisoning. The plant also exhibits CNS depressant, anti-convulsant, enzyme inhibiting, anti-cancer and anti-bacterial activities. The present review explores its description, traditional uses, chemical constituents, pharmacological activity and commercial importance so that its potential as a multipurpose medicinal agent can be understood and appreciated.Keywords
Vitex negundo Linn, Pharmacological Activities, Chemical Constituents.
- Simultaneous Estimation of Levofloxacin Hemihydrate and Ornidazole by High Performance Liquid Chromatography in Pharmaceutical Dosage Form
Authors
1 Department of Pharmacy, Savitri Devi Memorial College of Pharmacy, Rajound, Kaithal, Haryana, IN
2 Department of Pharmacy, Keshav College of Pharmacy, Assandh, Haryana, IN
3 Department of Pharmacy, Mallige College of Pharmacy, Bangalore, Karnataka, IN
4 Department of Pharmacy, B. S. Anangpuria Institute of Pharmacy, Faridabad, Haryana, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 11 (2011), Pagination: 1784-1788Abstract
A new simple, selective, rapid, precise and economical reverse phase isocratic High Performance Liquid Chromatography (HPLC-RP) method has been developed for the simultaneous estimation of Levofloxacin hemihydrate and Ornidazole in pharmaceutical preparations using Kromacil 5 μ 100 A C18, 150 x 4.6 mm column and the mobile phase consisted of acetonitrile:water (40:60), pH adjusted to 3.0 *#177; 0.05 with dil. Orthophosphoric acid. The flow rate was kept at 1.3 ml/min. The Ultraviolet Violet (U.V.) detection was done at 302 nm. The retention times for these drugs were 1.051 min and 1.777 min, respectively. The HPLC method was validated. The present method was found to be specific. The number of theoretical plates came out to be fairly high, i.e., 1082 and 2051 for the Levofloxacin hemihydrate and Ornidazole respectively. The tailing factor came out to be 1.26 and 1.11 for Levofloxacin hemihydrate and Ornidazole respectively. The relative standard deviation or precision was calculated to be 0.5 and 0.3 for Levofloxacin hemihydrate and Ornidazole respectively. The method was tested for its robustness as the resolution came out to be 5.09. With this present method, the calibration curve was found to be linear and run time was just 3 min., which made the method rapid and economical.