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Sujoy Das ¹, Amit Roy ², Prabhat K. Das ¹

Affiliations
1 Department of Pharmaceutics, GRY Institute of Pharmacy, Borawan, Khargone-451228, IN
2 Columbia Institute of Pharmacy, Raipur, IN

Abstract

Results of ethnomedicinal studies carried out in the state of Madhya Pradesh, India that lies between 22° 11' 0" North, 75° 35' 0" East are presented. The usage of wild plants by the nimari people for the cure of cuts and wounds is described. The use of 52 species belonging to 39 families have been enumerated. The plants not only contain antiseptic value but also have regenerative and healing properties. Leaves, fruit and seeds are crushed and applied as a paste and decoction in the combination of water, honey or coconut oil and powder made from fresh or dried material have been reported. In addition, preparations were taken internally by preparing mixture with Aloe vera and sugar.

Keywords

Ethnomedicinal, Wounds, Antiseptic, Decoction.

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S. Vaghasia ¹, V. Kanthiya ², Sujoy Das ², R. K. Sethi ³, A. Choudhury ⁴

Affiliations
1 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228(MP), IN
2 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN
3 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone-451228 (MP), IN
4 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN

Abstract

In this study, tablets were formulated by wet granulation technique taking Paracetamol as model drug. Three mucoadhesive polymers namely hydroxyl propyl methyl cellulose K4M, methyl cellulose and poly vinyl pyrolidone were used for preparation of coating solution (1%,2% and 3%) as well as for development of sustained release tablets. All the evaluation were carried out before and after coating like thickness and diameter, weight variation, friability, disintegration, swelling index, Mucoadhesive strength, drug content and in-vitro release study. All the physical evaluation parameters were increases after coating when compare with normal tablet. Normal tablets were showed 95% release within 30 min where coated tablets showed 98% release over a period of 6hr. in water and release was diffusion controlled confirmed by Higuchi’s plot. Thus, the present study concluded that, we can development of sustained release formulation can be possible by coating using the mucoadhesive polymers.

Keywords

Punch, Coating, Diffusion, Sustained

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Sanjib Bahadur ¹, Amit Roy ¹, Ranabir Chanda ², Ananta Choudhury ¹, Sujoy Das ³, Suman Saha ¹, Shashikant Chandrakar ¹, Pushpa Prasad ¹

Affiliations
1 Columbia Institute of Pharmacy, Vill. Tekari, Near Vidhan Sabha, Raipur (C.G), IN
2 Bengal School of Technology, Sugandha, Delhi Road, Hooghly (W.B), IN
3 GRY Institute of Pharmacy, Vidya Vihar, Borawan, Khargone (M.P), IN

Abstract

The objective of any formulation is to deliver drug to the patient in the definite amount, at the required rate, and maintains the stability of drug over the product's shelf life. To produce a drug formulation in a final dosage form, a number of pharmaceutical ingredients are required. In selecting excipients for pharmaceutical dosage forms and drug products the development pharmacist should be certain about the existing standards and safety parameters of the excipients. This will assure the consistent quality and functioning of the excipient. The selection and testing of non active ingredients or excipient in the design of drug dosage form present to the formulator the challenge of predictive foresight. While the ability to solve problems when they occur is a valuable attribute, the ability to prevent the problem through adequate experimental design is a virtue. The safety and biodegradability issues related to synthetic excipients have necessitates development of new natural excipients. Newer excipients provide the means for simplifying formulation development, and improving overall operational costs while preserving the quality that is expected by the industry. This review focuses on need to develop such newer natural excipients which shall be utilized to develop efficient dosage forms and the economics involved in doing so.

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