Informatics Publishing Limited

Chandan Das ¹, Sujit Dash ², Durga Charan Sahoo ³, Arnabaditya Mohanty ⁴

Affiliations
1 Dpt. of Pharmacognosy, the Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali, Bargarh-768 029, Odisha, IN
2 Institute of Pharmacy and Technology, Salipur, Cuttack-754 202, Odisha., IN
3 Dadhichi College of Pharmacy, Vidya Vihar, Sundargram, Cuttack-754 002, Odisha, IN
4 The Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali, Bargarh-768 029, Odisha, IN

Abstract

Butea monosperma, a popular Indian medicinal plant, has long been used in Ayurvedic system of medicine. In sanskrit it is called as 'Palasa'. The plant has been found to possess diverse number of pharmacological activities. The present paper gives an account of updated information on its phytochemical and pharmacological activities. The review reveals that wide range of phytochemical constituents have been isolated from the plant and it possess important activities like diarrhoea, dysentery, inflammation, ringworm, aphrodisiac, anthelmentic, tumor, piles and ulcer, cold, cough, menstrual disorder, analgesic and diuretic. Various other activities like hepatoprotective, osteoprotective, anti-inflammatory, antihyperglycemic, antifilaria, antioxidant, anthelmentic, antimicrobial, anticonvulsant, antifertility and aphrodisiac been reported. These reports are very encouraging and indicate that herb should be studied more extensively for its therapeutic benefits.

Keywords

Butea monosperma, Ethnobotanical, Phytoconstituents and Pharmacological Activities.

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Bishwanath Mishra ¹, Durga M. Kar ², Laxmidhar Maharana ², Sujit Dash ¹, Ganesh P. Mishra ³

Affiliations
1 Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, IN
2 Siksha ‘O’ Anusandhan University, School of Pharmaceutical Sciences, Kalinga Nagar, Ghatikia, Bhubaneswar, Odisha, IN
3 Biological E. Limited, Jubilee Hills, Hyderabad, IN

Abstract

Diabetes mellitus (DM) is a common endocrine disorder, now considered as a major global health problem which is affecting around 9.3% of world population and its incidence is increasing day by day. In India, several plants having hypoglycemic property are traditionally used in management of diabetes. Solanum torvum (Swartz) (ST) plant belonging to family Solanaceae; is medicinally reported and claims to cure various diseases in Indian traditional system of medicine (Ayurveda) and also in folklore and as per previous report, the decoction of its fruits is very useful in the treatment of diabetes. The thrust of this investigation is to examine the hypoglycemic efficacy of methanolic fractions (50, 100 and 200mg/kg body wt.) of ST fruits (MFST) from defatted hydro-alcoholic extract in normoglycemic, followed by Streptozotocin (45mg/kg) induced diabetic, and glucose loaded hyperglycemic rats by single as well as multiple oral administration in contrast to the standard drug glibenclamide (2.5mg/kg body wt.). In the beginning of the investigation, acute oral toxicity study of MFST was carried out in rats to determine the dose for experiment animals. The study report showed that the MFST (200mg/kg) significantly (pth hour and 3^rd hour respectively during the single dose study and from the 15^th day to 30^th day in multi dose study. The blood glucose level decreasing activity of MFST may be due to the secondary metabolites such as flavonoids, tannins and phenolic compounds present in it. Hence the present investigation report reveals that MFST possess significant hypoglycemic and anti-diabetic activity which persuades the traditional use of the plant for the treatment or management of diabetes mellitus.

Keywords

Antidiabetic, Solanum torvum (Swartz) fruits, Normoglycemic, Streptozotocin, Glibenclamide.

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