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Hayaza, Suhailah
- The Role of Social Support on Coping Stress in Type‑2 Diabetes Mellitus Patients with Gangrene Complications
Abstract Views :279 |
PDF Views:0
Authors
Ayu Aisah Zuraidah
1,
Arif Nur Muhammad Ansori
2,
Suhailah Hayaza
3,
Ilham Nur Alfian
1,
Suryanto
1,
Nurul Hartini
1
Affiliations
1 Faculty of Psychology, Universitas Airlangga, Kampus B Universitas Airlangga, 60286, ID
2 Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, ID
3 Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, ID
1 Faculty of Psychology, Universitas Airlangga, Kampus B Universitas Airlangga, 60286, ID
2 Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, ID
3 Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, 60115, ID
Source
Indian Journal of Public Health Research & Development, Vol 11, No 1 (2020), Pagination: 988-991Abstract
This study aims to identify how the type of coping stress strategy for the type‑2 diabetes mellitus patients, who experienced gangrene complication. Coping stress strategy is an efforts strategy to overcome feelings of stress due to illness. Coping stress strategy in this study is divided into two types, namely problem‑solving effort, and emotion‑focused coping. The method used in this study was a qualitative approach by taking three people with type‑2 diabetes mellitus and complications of gangrene as participants. The method used for selecting the participants was a purposive approach. The data were collected using structured interviews and field notes. The data was analyzed by using thematic analysis with a theory‑driven approach. The result shows that the three participants had a coping stress strategy to heal their stress while experiencing diabetes and gangrene complication. Patients were able to cope well with stress control routine, change their eating patterns, look for information on diabetes mellitus, and exercise regularly. Patients also got supports from professionals, family, and friends. Coping stress strategy techniques for each different subject depend on their surroundings. This study found that there is three dominant coping stress strategy chosen by the patients which are the planful problem solving and the seeking social support that belongs to the problem‑solving effort section, and the positive appraisal section that belongs to the emotion‑focused coping section. However, three patients also performed stress diversion, called escape/avoidance, to cope with their stress.Keywords
coping stress strategies, type‑2 diabetes mellitus patients, gangrene complication.- Immunomodulatory Activity of Okra Raw Polysaccharide Extract by Regulating Tnf-a, Ifn-g Levels, and Cell Apoptosis in Den-induced Mice
Abstract Views :87 |
PDF Views:0
Authors
Suhailah Hayaza
1,
Win Darmanto
1,
Sri Puji Astuti Wahyuningsih
1,
Raden Joko Kuncoroningrat Susilo
1,
Saikhu Akhmad Husen
1,
Dwi Winarni
1,
Ruey- an Doong
2
Affiliations
1 Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya 60115, ID
2 Institute of Analytical and Environmental Sciences, National Tsing Hua University, Sec. 2 Kuang Fu Road, Hsinchu 30013,, TW
1 Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya 60115, ID
2 Institute of Analytical and Environmental Sciences, National Tsing Hua University, Sec. 2 Kuang Fu Road, Hsinchu 30013,, TW
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 546-550Abstract
Okra (Abelmoschus esculentus L.) was commonly found in tropical and sub-tropical country. It contains high level of polyssacharide and secondary metabolites. Hence, no in vivo studies have explored okra’s ability as immunomodulatory agent toward hepatocarcinogenic condition. This study aims to evaluate the effect of okra raw polysaccharide extract (ORPE) on cytokine levels and cell apoptosis and necrosis of mice with hepatocarcinogenic condition induced by diethylnitrosamine (DEN). A total of 36 adult male mice (BALB/C) were acclimatized for 14 days and were randomly divided into six groups: the normal control group without any treatment (CN), negative control induced by DEN with no ORPE administration (C-), positive control induced by DEN with 10mg/kg BB doxorubicin administration (C+), and ORPE treatment of dose 50mg/kg BW (P1), 100mg/kg BW (P2) and 200mg/kg BW (P3) which previously have been injected with DEN. The level of interferon-gamma (IFN-γ) and tumor necrosis factor-α (TNF-α) were measured using the ELISA method. The percentage of apoptosis and necrosis were analyzed using flow cytometry. The administration of ORPE significantly increased the level of TNF-α in DEN-induced liver cancer mice. While it did not cause significant changes in the percentage of apoptosis in mice hepatocytes. These results suggest that ORPE has an immunomodulatory effect on the cytokine of hepatocarcinogenic mice which can be used as a cancer therapy in nutraceutical and pharmaceutical industries.Keywords
Okra, Raw polysaccharide extract, Liver cancer, Cytokine, Apoptosis.References
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- Hayaza S, Wahyuningsih SPA, Susilo RJK, Husen SA, Winarni D, Doong RA, Darmanto W. Dual role of immunomodulation by crude polysaccharide from okra against carcinogenic liver injury in mice. Heliyon. 2021; 7(2):e06183.
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