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Debnath, Subal
- Antidiabetic Effect of Luffa acutangula Fruits and Histology of Organs in Streptozotocin Induced Diabetic in Rats
Authors
1 Department of Pharmacology, Jogaiah Institute of Technology and Sciences, College of Pharmacy, IN
2 Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, W.G, Andhra Pradesh, IN
3 Gogulakrishna College of Pharmacy, Sulurpet, Andhra Pradesh, IN
4 Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet, Andhra Pradesh - 502 277, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 64-69Abstract
The Antidiabetic activity of fruits and seeds ethanolic extract of Luffa acutangula (Cucurbitaceae) was studied in a Streptozotocin {STZ) induced diabetic in rats. The acute toxicity and lethality (LD50) and the Phytochemicals analysis of the extract were also evaluated. The results showed that the extract (200 and 400 mg/kg) significantly (P<0.05) reduced fasting blood sugar of Streptozotocin diabetic rats in a dose-related manner, with maximum hypoglycemic effect at after 21 days. Acute toxicity and lethality test of the extract in rats gave an oral LD50 greater than 5 g/kg. It is clearly evident from the study that the streptozotocin administration caused the significant increase in the blood glucose level at 0 day (p<0.001). The 50% ethanolic extract of the fruits of Luffa acutangula showed the significant effect compared with the respective diabetic control group, decrease the blood glucose level at a dose of 200 mg/kg and 400 mg/kg (p<0.001), the standard drug glibenclamide also showed the significant decrease the blood glucose level after 21 days (241.33-105.33, p<0.001). Finally the 400 mg/kg and the standard drug showed the significant decrease in the blood glucose level after 21 days treatment (p<0.001). The findings indicate that the leaves of Luffa Acutangula may be beneficial as an Antidiabetic therapy.Keywords
Streptozotocin, Luffa acutangula, Antidiabetic.- Effect of leave Extract of Prunus persica Linn on Acute Inflammation in Rats
Authors
1 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
2 Rajiv Gandhi College of Pharmacy, Nautanwa, Maharajganj, UP– 27316, IN
3 I.B.S.D. Takyelpat ,Imphal, Manipur, IN
4 Sri Krupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet. Andhra Pradesh – 502277, IN
5 R. K. Pharmacy College, Kasipur, Suri – Santhiaon, Azamgarh, UP– 276001, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 1 (2011), Pagination: 38-40Abstract
Prunus persica Linn (L) widely distributed in Manipur, India. The leaves were used in folklore/traditional medicine to treat several inflammatory pathologies such as greenish swelling (gland), oedema etc. Reactive oxygen species as well as reactive free radicals such as hydroxyl (OH), nitric oxide (NO) etc. contribute significantly to these pathologies. In this study, antiinflammatory activity of the aqueous extracts (AEPp) of Prunus persica L leaves was evaluated on carrageenin induced oedema. The test sample at the dose of 200 mg/kg/p.o. were found to cause significant (***P<0.001) inhibition of carrageenin induced oedema. The test samples AEPp show the protection against inflammation less than standard diclofenac sodium 8mg/kg b.w. These observations established the anti-inflammatory effect of Prunus persica L leaves aqueous extract in acute inflammation.Keywords
Prunus persica, Inflammation.- In-Vitro Antimicrobial Synergistic and Anti-Tb Activities of Opuntia dillenii Hydro-Alcoholic Extract
Authors
1 Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (mdl), Dist. Medak, Siddipet, Andhra Pradesh – 502 277, IN
2 Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (MDL), Dist. Medak, Siddipet, Andhra Pradesh – 502 277, IN
3 University Institute of Pharmacy, Pt. Ravishankar Sukla University, Raipur, C.G., IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 2 (2011), Pagination: 67-71Abstract
The objective of the present study was to evaluate the synergistic antimicrobial and anti-tubercular activities of Opuntia dillenii aqueous methanolic extract. Antibacterial study was carried out by plate hole diffusion or agar well diffusion assay to determine the growth inhibition of bacteria. Antifungal activity was performed by the use of Saubouraud dextrose agar medium (SDA). The synergistic activity study was calculated by means of Cup plate method (Kirbauy bauer technique) using two wells in a plate. The aqueous methanolic plant extract of Opuntia dillenii (500 μg/ml) was used in combination with oxytetracycline (500 μg/ml). Anti-tubercular assay was performed using Micro plate Alamar Blue Assay (MABA) using the suspension of Mycobacterium tuberculosis H37Rv strain. The concentrations of plant extract were used are 1000 μg/ml, 500 μg/ml, 250 μg/ml, 125 μg/ml, 62.5 μg/ml. The medicinal plant appear to have a broad antimicrobial activity spectrum, they could be useful in antiseptic and disinfectant formulation as well as in anti-tubercular activity. Among the various micro organisms, the aqueous methanolic extract was more active against Micrococcus leuteum, Proteus mirabilis. In antifungal activity of the aqueous methanolic extract shows positive results for all fungus. The antitubercular activities were compared with standard drug Rifampicin. The aqueous methanolic extract was having more percentage inhibition when compared to other extracts.
Keywords
Opuntia dillenii, Mycobacterium tuberculosis, Micro Plate Alamar Blue Assay.- Antibacterial, Anthelmintic, Analgesic and Anti-Inflammatory Activity of Conventional and Microwave Assisted Synthesized 3-(Substituted)-2-Phenylquinazolin-4(3h)-One
Authors
1 Department of Pharmaceutical Chemistry, Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Mdl:Kondapak, Dist. Medak, Siddipet, Andhra Pradesh – 502 277, IN