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Mukherjee, Soma
- Palladium(II) Complex Induces Apoptosis through ROS-Mediated Mitochondrial Pathway in Human Lung Adenocarcinoma Cell Line (A549)
Authors
1 Immunology Lab, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700 019, IN
2 Department of Environmental Science, University of Kalyani, Nadia 741 235, IN
Source
Current Science, Vol 107, No 10 (2014), Pagination: 1711-1719Abstract
Treatment for lung cancer is still far from satisfactory. Therefore, there is a call for novel anticancer agents. In the present study, the anticancer activity of [Pd(L)Cl], 1a complex towards A549 human lung adenocarcinoma cells was investigated. [Pd(L)Cl], 1a inhibited the growth of A549 cells in a time and dosedependent manner. The IC50 value was 10 μM after 24 h treatment. Flow cytometric analyses revealed a dose-related increase in the percentages of cells in the Sub-G0/G1 state, indicative of apoptosis which was further confirmed by Annexin V binding assay, via a ROS-mediated mitochondria-dependent pathway. Western blot analysis showed that 1a complex induced Bax expression to desintegrate the outer mitochondrial membrane and causing cytochrome c release, associated with the activation of caspase-3. All of these signal transduction pathways are involved in initiating apoptosis. [Pd(L)Cl], 1a seems to represent a potentially active drug against non-small cell lung cancer A549 cell line in vitro, and further studies in vivo are warranted.Keywords
Apoptosis, Lung Cancer, Palladium(II) Complexes, Reactive Oxygen Species.- Nutrition and Brain
Authors
1 Calcutta University, IN
Source
Indian Science Cruiser, Vol 29, No 4 (2015), Pagination: 14-16Abstract
Proper functioning of the brain is essentially required to lead a physically and mentally healthy life, and accordingly it is essential that we have a healthy and active brain functioning properly. Different areas of the brain require different types of nutrients and in order to optimize proper functioning, a well balanced diet is essentially required. The kind of food we eat determines a lot about how we feel and how much energy we have. Specific food targeted to specific areas of the brain can modify our personality and in fact define who we are. Our emotions, behavior and overall health are all guided by the brain and the brain seeks healthy and appropriate food. Our food and the kind of food we eat can make or break our lives. If we do not pay enough attention, then the food we consume can be destructive to our daily life or it can be our best friend if chosen wisely.