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Kolhe, Smita
- Updated Review on Orally Disintergarting Tablets: Advancement in Current Trends
Abstract Views :246 |
PDF Views:1
Authors
Affiliations
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi 2Emcure Pharmaceuticals, Pune, IN
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi 2Emcure Pharmaceuticals, Pune, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 2 (2013), Pagination: 45-51Abstract
There is an increasing demand for the easily administered dosage forms and oral routes of drug administration have wide acceptance upto50-60% of total dosage forms. The oral fast dissolving systems are defined as oral drug delivery systems that dissolve or disintegrate within a few seconds to a few minutes of placement in the mouth and that do not require water to aid swallowing. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-disintegrating tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed orally disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently receiving the highest standards. Achieving the highest standards in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Fast- or mouth dissolving OR Orally disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water.Keywords
Mouth Dissolving Tablets, Superdisintegrants, Evaluation of Mouth Dissolving Tablets
References
- Kaushik, D., Dureja, H., and Saini, T. R., Indian Drugs.,2004 , 41 (4), 503- 508.
- Kuchekar, B.S., Badhan, A.C., and Mahajan, H.S., Pharma Times., 2003, 6 (35), 7-11.
- Kottke, M.K., Rhodes, C.T., and Grady, L.T., Drug Dev.Ind.Pharm., 1989, 15(10), 1635-1692.
- Reddy, L.H., Ghosh, B., and Rajneesh; Indian J. Pharm. Sci., 2002, 39 (8), 405-409.
- Ansel, H.C., In., Pharmaceutical Dosage Forms and Drug Delivery System, 6th Edn., B.I. Waverly Pvt.Ltd., New Delhi., 1995, 99-154.
- Biradar, S. S., Bhagavati, S. T., Kuppasad I. J., Fast Dissolving Drug Delivery Systems: A Brief Overview, Internet J. Pharmacology, 2006, 4(2).
- Kuccherkar B.S., Badhan A.C., Mahajan H.S., Mouth dissolving tablets: A novel drug delivery system, Phrma Times, 2003, 35, 3- 10.
- Amin, A.F., Shah, T.J., Bhadani, M.N., Patel, M.M., Emerging trends in orally disintegrating tablets,www.pharminfo.net, 2005.
- Lailla, J.K., Sharma, A.H., Freeze-drying and its applications, Indian Drugs, 1993, 31, 503-513.
- Seager, H., Drug delivery products and zydis fast dissolving dosage form, J. Pharm. Phamacol., 1998, 50, 375-382.
- Renon, J.P., Corveleyn, S., Freeze-dried rapidly disintegrating tablets, US Patent No. 6,010,719, 2000.
- Masaki, K., Intrabuccaly disintegrating preparation and production there of, US Patent No.5, 466,464, 1995.
- Pebley, W.S., Jager, N.E., Thompson, S.J., Rapidly disintegrating tablets, US Patent No. 5,298,261, 1994.
- Allen, L.V., Wang, B., Method of making a rapidly dissolving tablet. US Patent No. 5,635,210, 1997.
- Allen, L.V., Wang, B., Process for making a particulate support matrix for making rapidly dissolving tablets. US Patent No. 5,587,180, 1996.
- Biradar, S. S., Bhagavati S. T., Kuppasad, I. J., Fast Dissolving Drug Delivery Systems: A Brief Overview, Internet J. Pharmacology, 2006, 4(2).
- Lachmann, L., Liebermann, H.A., Kiang, J.L., The theory and practice of Industrial Pharmacy, 3rd Ed., Varghese Publishing House, Bombay, 1998, 430-440.
- Kaushik, D, Dureja, H, Saini, T. R., Mouth Dissolving Tablets: A review. Indian Drugs, 2004, 41(4), 187-193.
- Yarwood, R.J., Kearny, K., Thomson A.R., Process for preparing solid dosage form for unpalatable pharmaceuticals, US Patent No. 5,738,875, 1998.
- Lalla, J.K., and Sharma, A.H., Indian Drugs., 1994, 31 (11), 503- 508.
- Rajyaguru, T.H., Indurwade, N.H., and Nakhat, P.D., Indian Drugs., 2002, 39(8), 405- 409.
- Yeola, B.S., Pisal, S.S., Paradkar, A.R., and Mahadik, K.R., Indian Drugs., 2000, 37 (7),312- 318.
- Seager, H., J.Pharm. Pharmacol., 1998, 50, 375-382.
- Indian Pharmacopoeia., 4th Edn., Vol-II., Controller of Publication., Govt. of India., New Delhi., 1996, 736.
- Lachman, L., In; Theory And Practice of Industrial Pharmacy., 3rd Edn., Varghese Publishing House., Mumbai., 1987, 297.
- Bandari S., Mittapalli R.K., Gannu R., Rao Y.M., Orodispersible tablets: An overview. Asian J Pharm. 2008; 2: 2–11.
- Knistch K.W., Production of porous tablets, US Patent No. 4,134,843, 1979.
- Roser B. J. and Blair J., Rapidly soluble oral dosage form, method of making same and composition, US
- Allen T., In: Particle size measurement, 5th ed. London: Chapmanand Hall, 1997:149–187.
- Alvarez-Lorenzo C., Go´mez-Amoza J.L., Martý´nez-Pacheco R., Souto C., Concheiro A., Evaluation of low-substituted hydroxypropylcelluloses (L-HPCs) as filler-binders for direct compression Int J Pharm. 2000; 197:107–116.
- Sunada H., Bi Y., Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technology. 2002; 122: 188–198.
- Koizumi K.I., Watanabe Y., Morita K., Utoguchi N., Matsumoto M., New method for preparing high porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material. Int J Pharm. 1997; 152: 127–131.
- Bi Y., Sunada H., Yonezawa Y., Danjo K., Otsuka A., Iida K., Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull. 1996; 44: 2121– 2127.
- Narazaki R., Harada T., Takami N., Kato Y., Ohwaki T., A new method for disintegration studies of rapid disintegrating tablet. Chem Pharm Bull. 2004, 52: 704–707.
- Motohiro O., Hayakawa E., Ito K., Tokuno M., Morimoto K., Watanabe K., US Patent Application 20010014340. 2001 Aug 16.
- Klancke J., Dissolution testing of orally disintegrating tablets. Dissolution Technol. 2003; 10(2): 6–8.
- El-Arini S.K., Clas S.D., Evaluation of disintegration testing of different fast dissolving tablets using the texture analyzer. Pharm Dev Technol. 2002; 7: 361–371.
- Abdelbary G., Eouani C., Prinderre P., Joachim J., Reynier J.P., Piccerelle P.H., Determination of the in-vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration. Int J Pharm. 2005; 292: 29–41.
- Evaluation of orally disintegratingtablets (ODTs) using precision compressive loading. http://www.boselectroforce.com/pdf/Appbrief_ODTs.
- Bi, Y.X., Sunda, H., Yonezawa, Y., Danjo, K., Otsuka, A., Iida, K., Chem.Pharm. Bull., 1996, 14 (11), 2121-2127
- Indian Pharmacopoeia., 4th Edn., Vol-II., Controller of Publication., Govt.of India., New Delhi., 1996, 735.
- The United States Pharmacopoeia-27/ National Formulary-22., Asia Edition., Rockville MD., 2000, 2303.
- Orally Disintergarting Tablets: Advancement in Current Trends
Abstract Views :997 |
PDF Views:2
Authors
Affiliations
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, IN
2 Emcure Pharmaceuticals, Pune, IN
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, IN
2 Emcure Pharmaceuticals, Pune, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 3 (2013), Pagination: 93-97Abstract
There is an increasing demand for the easily administered dosage forms and oral routes of drug administration have wide acceptance upto 50-60% of total dosage forms. The oral fast dissolving systems are defined as oral drug delivery systems that dissolve or disintegrate within a few seconds to a few minutes of placement in the mouth and that do not require water to aid swallowing. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-disintegrating tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed orally disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently receiving the highest standards. Achieving the highest standards in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Fast- or mouth dissolving OR Orally disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water.Keywords
Mouth Dissolving Tablets, Superdisintegrants, Evaluation of Mouth Dissolving TabletsReferences
- Kaushik, D., Dureja, H., and Saini, T. R., Indian Drugs.,2004 , 41 (4), 503- 508.
- Kuchekar, B.S., Badhan, A.C., and Mahajan, H.S., Pharma Times., 2003, 6 (35), 7-11.
- Kottke, M.K., Rhodes, C.T., and Grady, L.T., Drug Dev. Ind. Pharm., 1989, 15(10), 1635-1692.
- Reddy, L.H., Ghosh, B., and Rajneesh; Indian J. Pharm. Sci., 2002, 39 (8), 405-409.
- Ansel, H.C., In., Pharmaceutical Dosage Forms and Drug Delivery System, 6th Edn., B.IWaverly Pvt.Ltd., New Delhi., 1995, 99-154.
- Biradar, S. S., Bhagavati, S. T., Kuppasad I. J., Fast Dissolving Drug Delivery Systems: A Brief Overview, Internet J. Pharmacology, 2006, 4(2).
- Kuccherkar B.S., Badhan A.C., Mahajan H.S., Mouth dissolving tablets: A novel drug delivery system, Phrma Times, 2003, 35, 3- 10.
- Amin, A.F., Shah, T.J., Bhadani, M.N., Patel, M.M., Emerging trends in orally disintegrating tablets,www.pharminfo.net, 2005.
- Lailla, J.K., Sharma, A.H., Freeze-drying and its applications, Indian Drugs, 1993, 31, 503-513.
- Seager, H., Drug delivery products and zydis fast dissolving dosage form, J. Pharm. Phamacol., 1998, 50, 375-382.
- Renon, J.P., Corveleyn, S., Freeze-dried rapidly disintegrating tablets, US Patent No. 6,010,719, 2000.
- Masaki, K., Intrabuccaly disintegrating preparation and production thereof, US Patent No.5, 466,464, 1995.
- Pebley, W.S., Jager, N.E., Thompson, S.J., Rapidly disintegrating tablets, US Patent No. 5,298,261, 1994.
- Allen, L.V., Wang, B., Method of making a rapidly dissolving tablet. US Patent No. 5,635,210, 1997.
- Allen, L.V., Wang, B., Process for making a particulate support matrix for making rapidly dissolving tablets. US Patent No. 5,587,180, 1996.
- Biradar, S. S., Bhagavati S. T., Kuppasad, I. J., Fast Dissolving Drug Delivery Systems: A Brief Overview, Internet J. Pharmacology, 2006, 4(2).
- Lachmann, L., Liebermann, H.A., Kiang, J.L., The theory and practice of Industrial Pharmacy, 3rd Ed., Varghese Publishing House, Bombay, 1998, 430-440.
- Kaushik, D, Dureja, H, Saini, T. R., Mouth Dissolving Tablets: A review. Indian Drugs, 2004, 41(4), 187-193.
- Yarwood, R.J., Kearny, K., Thomson A.R., Process for preparing solid dosage form for unpalatable pharmaceuticals, US Patent No. 5,738,875, 1998.
- Lalla, J.K., and Sharma, A.H., Indian Drugs., 1994, 31 (11), 503- 508.
- Rajyaguru, T.H., Indurwade, N.H., and Nakhat, P.D., Indian Drugs., 2002, 39(8), 405- 409.
- Yeola, B.S., Pisal, S.S., Paradkar, A.R., and Mahadik, K.R., Indian Drugs., 2000, 37 (7),312- 318.
- Seager, H., J.Pharm. Pharmacol., 1998, 50, 375-382.
- Indian Pharmacopoeia., 4th Edn., Vol-II., Controller of Publication., Govt. of India., New Delhi., 1996, 736.
- Lachman, L., In; Theory And Practice of Industrial Pharmacy., 3rd Edn., Varghese Publishing House., Mumbai., 1987, 297.
- Bandari S., Mittapalli R.K., Gannu R., Rao Y.M., Orodispersible tablets: An overview. Asian J Pharm. 2008; 2: 2–11.
- Knistch K.W., Production of porous tablets, US Patent No. 4,134,843, 1979.
- Roser B. J. and Blair J., Rapidly soluble oral dosage form, method of making same and composition, US
- Allen T., In: Particle size measurement, 5th ed. London: Chapmanand Hall, 1997:149–187.
- Alvarez-Lorenzo C., Go´mez-Amoza J.L., Martý´nez-Pacheco R., Souto C., Concheiro A., Evaluation of low-substituted hydroxypropylcelluloses (L-HPCs) as filler-binders for direct compression Int J Pharm. 2000; 197:107–116.
- Sunada H., Bi Y., Preparation, evaluation and optimization of rapidly disintegrating tablets. Powder Technology. 2002; 122: 188–198.
- Koizumi K.I., Watanabe Y., Morita K., Utoguchi N., Matsumoto M., New method for preparing high porosity rapidly saliva soluble compressed tablets using mannitol with camphor, a subliming material. Int J Pharm. 1997; 152: 127–131.
- Bi Y., Sunada H., Yonezawa Y., Danjo K., Otsuka A., Iida K., Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull. 1996; 44: 2121–2127.
- Narazaki R., Harada T., Takami N., Kato Y., Ohwaki T., A new method for disintegration studies of rapid disintegrating tablet. Chem Pharm Bull. 2004, 52: 704–707.
- Motohiro O., Hayakawa E., Ito K., Tokuno M., Morimoto K., Watanabe K., US Patent Application 20010014340. 2001 Aug 16.
- Klancke J., Dissolution testing of orally disintegrating tablets. Dissolution Technol. 2003; 10(2): 6–8.
- El-Arini S.K., Clas S.D., Evaluation of disintegration testing of different fast dissolving tablets using the texture analyzer. Pharm Dev Technol. 2002; 7: 361–371.
- Abdelbary G., Eouani C., Prinderre P., Joachim J., Reynier J.P., Piccerelle P.H., Determination of the in-vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration. Int J Pharm. 2005; 292: 29–41.
- Evaluation of orally disintegratingtablets (ODTs) using precision compressiveloading.http://www.boselectroforce.com/pdf/Appbrie f_ODTs.
- Bi, Y.X., Sunda, H., Yonezawa, Y., Danjo, K., Otsuka, A., Iida, K., Chem. Pharm. Bull., 1996, 14 (11), 2121-2127
- Indian Pharmacopoeia., 4th Edn., Vol-II., Controller of Publication., Govt.of India., New Delhi., 1996, 735.
- The United States Pharmacopoeia-27/ National Formulary-22., Asia Edition., Rockville MD., 2000, 2303.
- Herbals Used in HIV: A Review
Abstract Views :486 |
PDF Views:2
Authors
Affiliations
1 Modern College of Pharmacy (For Ladies), Moshi, Borhadewadi, Dehu Alandi Road, Pune, MS, India-412105, IN
1 Modern College of Pharmacy (For Ladies), Moshi, Borhadewadi, Dehu Alandi Road, Pune, MS, India-412105, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 5 (2013), Pagination: 275-282Abstract
Herbal medicines are often used as primary treatment for HIV/AIDS and for HIV related problems. In general, traditional medicines are not well researched, and are poorly regulated. This review deals with the evidence and safety concerns related to the use of two specific herbals. Efforts should be made by mainstream health professionals to provide validated information to traditional healers and patients on the judicious use of herbal remedies. This may reduce harm through failed expectations, pharmacologic adverse events including possible drug/herb interactions and unnecessary added therapeutic costs. Efforts should also be directed at evaluating the possible benefits of natural products in HIV/AIDS treatment.References
- Fairfield KM, Eisenberg DM, Davis RB, Libman H, Phillips RS. Patterns of use, expenditures, and perceived efficacy of complementary and alternative therapies in HIV-infected patients. Arch Intern Med. 1998: 2257-2264 .
- F. S. K. Barar. Essentials of pharmacotherapeutics, S. Chand and Company Ltd, Fourth Edition. 2002: 498-500. 3. Kumarasamy N, Patel A, Pujari S. Antiretroviral therapy in indian setting. Indian J Med Res. 134; .2011: 787-800.
- Babb DA, Pemba, Seatlanyane P, Charalambous S, Curchyard G, Grant AD. Use of traditional medicine in the era of antiretroviral therapy experience from South Africa eJIAS. MedGenMed .2004: B10640.
- Dr. Chandrakant R. Kokare. Pharmaceutical Microbiology: Principle and applications. Nirali Prakashan. Fifth Edition. 2008:13.1-13.24
- Drs. Frawley. D. ‘An Ayurvedic guide to Herbal Medicine’. 1992:155-158.
- Kokate C, Purohit A and Gokhale S. Pharmacognosy, Forty First Edition, Nirali Prakashan. 2008: 11.103, 8.23, 13.79, 20.5.
- Surjushe A, Vasani R and Saple O. Herbal medicine for Alovera. Indian J Dermatol. 2008:163-166 .
- Svoboda. R. ‘Ayurveda Life, Health and Longevity’. International Journal. 1993: 240 .
- Kazhilac.C and Hedimbi.M. Ethnomedicinal plants and other natural products with anti-HIV active compounds. International Journal. 2010: 74-91.
- Vermani.K and Garg.S. Herbal medicine for sexually transmitted diseases and AIDS. Journal of Ethnopharmacology. 2002: 49-66.
- Mill. E, Cooper. C, Seely. O, Kanfe. African herbal medicine in treatment of HIV. Nutritional Journal. 2005:19-30.
- Sharma P, Sharma O, Vasudeva N, Mishra D and Sing S. Anti- HIV substance of natural origin an updated account. Natural Product Radiance. 5(1); 2006: 70-78.
- Ping J, Macheimer E. Herbal medicine for treating HIV infection and AIDS.2009: 1-8.
- Shi D, Peng Z .Placebo-controlled clinical study on qiankunning for HIV/AIDS. China Journal. 21; 2003:1472-1474.
- Updated Review on Orally Disintergarting Tablets:Advancement in Current Trends
Abstract Views :192 |
PDF Views:0
Authors
Affiliations
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, IN
2 Emcure Pharmaceuticals, Pune, IN
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, IN
2 Emcure Pharmaceuticals, Pune, IN
Source
Research Journal of Science and Technology, Vol 5, No 4 (2013), Pagination: 404-411Abstract
There is an increasing demand for the easily administered dosage forms and oral routes of drug administration have wide acceptance upto 50-60% of total dosage forms. The oral fast dissolving systems are defined as oral drug delivery systems that dissolve or disintegrate within a few seconds to a few minutes of placement in the mouth and that do not require water to aid swallowing. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-disintegrating tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed orally disintegrating tablets, as they may take up to a minute to completely disintegrate. Oral delivery is currently receiving the highest standards. Achieving the highest standards in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. Fast- or mouth dissolving OR Orally disintegrating tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water.Keywords
Mouth Dissolving Tablets, Superdisintegrants, Evaluation of Mouth Dissolving Tablets.- Formulation and Evaluation of Solid Dispersion by Novel Technique
Abstract Views :200 |
PDF Views:2
Authors
Affiliations
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, Ms, IN
2 P.E.S’s, Modern College of Pharmacy, Nigdi, Pune, Ms, IN
3 Emcure Pharmaceuticals Limited, Bhosari, Pune, Ms, IN
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, Ms, IN
2 P.E.S’s, Modern College of Pharmacy, Nigdi, Pune, Ms, IN
3 Emcure Pharmaceuticals Limited, Bhosari, Pune, Ms, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 4 (2013), Pagination: 206-214Abstract
Hot melt extrusion (HME) is the most widely applied processing techniques, with its several advantages including enhancement of the dissolution rate and bioavailability, controlling or modifying drug release, taste masking, stabilizing the active pharmaceutical ingredient (API). Hot Melt Extruded dosage forms are complex mixtures of API, plastisizers and polymer carriersin which the molten thermoplastic polymers during the extrusion process can function as thermal binders and/or release retardants. Present investigation deals with enhancement of dissolution rate and hence solubility of Dapsone (Dap). Dap is a primary used for treatment of Dermatitis herpetiformis, as an antibacterial drug for susceptible cases of leprosy with long half life of 52-56 hrs. Solubility enhancement techniques are available in wide range but HME was the preferred technique due to its several advantages. Copovidone (Kollidon VA64) as polymer and polyethylene glycol (PEG 4000), polyoxy 35 castor oil (Cremophor EL) and sorbiton monolaurate (Montane 20 PHA) as plasticizers were studied and optimized. Evaluation techniques like saturation solubility, effect of temperature on preparation of complexes, differential scanning calorimetry (DSC), x-ray diffraction (XRD), Infra red (IR), dissolution and in vitro permeability studies were carried out. Results concluded enhanced dissolution and solubility. Stability studies at 40°C/75 % RH (relative humidity) showed that the sample is stable even after 3 months study. HME is simple and efficient method to improve dissolution and permeability of poorly water soluble Dap.Keywords
Melt Extrusion, Solubility, Glass Transition Temperature, Plasticizers, BCS Class II.- Formulation Development of Solid Dispersion Prepared by Newer Approach:A Research
Abstract Views :210 |
PDF Views:1
Authors
Affiliations
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, MS, IN
2 P.E.S’s, Modern College of Pharmacy, Nigdi, Pune, MS, IN
3 Emcure Pharmaceuticals Limited, Bhosari, Pune, MS, IN
1 P.E.S’s, Modern College of Pharmacy (For Ladies), Moshi, Pune, MS, IN
2 P.E.S’s, Modern College of Pharmacy, Nigdi, Pune, MS, IN
3 Emcure Pharmaceuticals Limited, Bhosari, Pune, MS, IN