Informatics Publishing Limited

Smita S. Aher ¹, Vaishali D. Sangale ¹, Ravindra B. Saudagar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

Mucoadhesion could be a field of current interest within the style of drug delivery systems. Mucoadhesive drug delivery system prolongs the continuance of the indefinite quantity kind at the positioning of application or absorption associate degreed facilitates an intimate contact of the indefinite quantity kind with the underline absorption surface and so contributes to improved and higher therapeutic performance of the drug. In recent years several such mucoadhesive drug delivery systems are developed for oral, buccal, nasal, body part and canal routes for each general and native effects.

Issues like high first-pass metabolism and drug degradation within the canal surroundings is circumvented by administering the drug via the buccal route. Moreover, speedy onset of action is achieved relative to the oral route and therefore the formulation is removed if medical care is needed to be out of print. It’s additionally attainable to administer medication to patients UN agency unconscious and fewer co-operative. To forestall accidental swallowing of medicine adhesive tissue layer indefinite quantity forms were advised for oral delivery, including adhesive tablets, adhesive gels, adhesive patches and plenty of alternative indefinite quantity forms with numerous combos of polymers, absorption enhancers. Additionally to the current, studies are conducted on the event of controlled or slow unharness delivery systems for general and native medical care of diseases.

Keywords

Buccal Region, Mucoadhesive, 1st Pass Metabolism.

Full Text

     

Vaishali D. Sangale ¹, Smita S. Aher ², Ravindra B. Saudagar ²

Affiliations
1 Department of Quality Assurance Technique, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, KCT’S RGS College of Pharmacy, Anjaneri, Nashik, 422 213, Maharashtra, IN

Abstract

Orally fast dissolving films are an emerging technology with fast onset of activity and improved patient compliance. It enhances the viability of API's and gives better medication use. These formulations are suitable for cold, allergy rhinitis, asthma attacks, CNS issue where fast onset of activity is needed for quicker help. The sublingual course of medication organization is extremely compelling following the medication retained through the sublingual veins by passes hepatic first pass metabolic procedure and also gives a better bioavailability. The present article outlines the definition viewpoints, manufacturing methods like solvent casting method, evaluation parameters and applications of fast dissolving films by sublingual route It has been estimated that approximately 84% of all sales of the top selling commercially available products are delivered via the oral route. Thin film drug delivery has come forward as an advanced alternative to the traditional tablets, capsules and liquids frequently associated with prescription and OTC medications. Similar in size, shape, and thickness to a postage stamp, thin film strips are classically designed for oral administration, with the user placing the strip on or under the tongue(sublingual)or along the inside of the cheeks(buccal).These drug delivery options allows the medication to bypass the first pass metabolism thereby making the medication further available. As the strip dissolves, the drug can enter the blood stream enterically, buccally or sublingually. The permeation is superior with sublingual than buccal than palatal region.

Keywords

Fast Dissolving Drug Delivery, Oral Strips, Sublingual Film, Mouth Dissolve.

Full Text

     

Dipti G. Phadtare ¹, Manisha N. Gaika ², Smita S. Aher ³

Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN

Abstract

The present study was aimed to develop a nanoemulsion based nasal spray of Azelastine hydrochloride for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. The aim of the present study was to prepare and evaluate different formulations of Azelastine Hydrochloride in nanoemulsion based using castor oil as oil phase, polysorbate 80 and cremophor RH 40 as surfactant used. Castor oil was selected as oil phase due to it's good solubilising capacity. The prepared formulations were characterized by pH, Drug content, Viscosity, Stability study etc. pH of all the formulations were found to be within the range between 5-7 and the nasal mucosa can tolerate the above mentioned pH of the formulations. Five different formulations were formulated with various values of oil (0.5-5%), Water (10-50%) and surfactant.The results indicated that the nanoemulsion system studied would be a promising tool for enhancing the nasal delivery of Azelastine hydrochloride.

Keywords

Azelastine Hydrochloride, Nasal Nanoemulsion, Polysorbate 80.

Full Text

     

Poonam R. Songire ¹, Smita S. Aher ², R. B. Saudagar ²

Affiliations
1 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik- 422213, Maharashtra, IN

Abstract

Oral drug delivery is the leading and the oldest segment of the total drug delivery system in the market. It is the greatest growing and most favored route for drug administration so oral controlled release of drugs becomes a very promising approach for drugs that having the shorter half-life and high dose frequency. Matrix tablets are an interesting option and new break through when developing an oral controlled release drugs delivery system. The use of various classes of release rate retardants like hydrophilic, hydrophobic, polymers and their degradation products are focused also. Release of drugs from matrices formulated with hydrophobic polymers is slower than from matrices formulated with hydrophilic Polymers.

The present article contains a brief review of various formulation approaches used in controlled release drug delivery systems, the role of polymers in the controlled delivery of many fast release drugs and the mechanism of drug release from these polymeric matrices. The oral controlled release system of many drugs has been known to be an essential part of formulation development in drug delivery systems. It has been the focus of pharmaceutical research for many years due to its various advantages over conventional dosage forms. Administering the drug for release in the blood at a controlled rate, to maintain relatively constant drug levels in plasma over a controlled period of time, can overcome many problems associated with conventional dosage forms. The applicability of these dosage forms is due to reduction in the frequencies of drug dosing, which lead to patient convenience and compliance. In addition, a reduction of wide fluctuations in plasma drug concentration peak can be obtained. As a result, toxicity and poor efficacy can be avoided, especially with drugs of narrow therapeutic indices. Such problems, associated with conventional dosage forms of many drugs, can be overcome by using controlled release drug delivery systems, to deliver the drug for absorption at a controlled rate over an extended period of time. The controlled release dosage form should be tailored so that variations in the components can lead to predictable alterations in the drug release profiles. Various controlled release drug delivery systems have different mechanisms to control the drug release rate, such as the osmotic pump, ion exchange resin and matrix systems which have been widely utilized as controlled release drug delivery approaches. Besides, polymers have often been used in the components of controlled release drug delivery systems.

Keywords

Introduction Matrix Tablet, Hydrophobic Polymer, Hydrophilic Polymer, Controlled Release Matrix System.

Full Text

     

Smita S. Aher ¹, Poonam R. Songire ², Ravindra B. Saudagar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN

Abstract

A sustained release matrix formulation for Albuterol Sulphate was designed and developed to achieve a 12 h release profile. Using HPMC K15M and HPMC K100M as an inert matrix forming agent to control the release of Albuterol Sulphate. The matrix tablets for these formulations were prepared by direct compression and their in-vitro release tests were carried out for a period of 12 hours using USP dissolution test apparatus (type II Paddle) at 37±0.5°C and 50 rpm speed. A 3² full factorial design was used for optimization by taking the concentration of HPMC K15M (X1) and HPMC K100M (X2) were selected as independent variables, whereas initial release at the (Y1, % drug release), (Y2, % drug Content) the concentration of Were chosen as dependent variables. The optimized formulation F9 follows Higuchi model and Korsemeyer - Pappas release kinetics with non- Fickian diffusion mechanism. From the study, it was concluded that the release of Albuterol Sulphate can be effectively controlled using combination of HPMC K15M, HPMC K 100M and Carbopol 940.

Keywords

Albuterol Sulphate, Gelucire43/01, Melt Method, Direct Compression Method, Factorial Design.

Full Text

     

Smita S. Aher ¹, Sagar T. Malsane ², R. B. Saudagar ¹

Affiliations
1 Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN
2 Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik-422213, Maharashtra, IN

Abstract

Nanosuspensions are important carriers to develop novel drug formulations. Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Nanosuspension technology solved the problem of drugs which are poorly aqueous soluble and less bioavailability. Stability and bioavailability of the drugs can be improved by the Nanosuspension technology. Techniques such as media milling and high pressure homogenization have been used commercially for producing nanosuspensions. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes.Nanosuspensions can also be used for targeted drug delivery when incorporated in the Ocular inserts and mucoadhesive hydrogels. Currently, efforts are being directed to extending their applications in site-specific drug delivery.

Keywords

Nanosuspension, Solubility Enhancement, Particle Size, Surfactant, Colloidal Dispersion, Oral Bioavailability.

Full Text