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Rastogi, Shweta
- A Study of Inducible Clindamycin Resistance in Staphylococci in a Tertiary Care Hospital in Western Uttar Pradesh
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Authors
Affiliations
1 Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), IN
1 Department of Microbiology, Saraswathi Institute of Medical Sciences, Hapur, (UP), IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 7-10Abstract
Aim: The aim of this study was to determine inducible clindamycin resistance in erythromycinresistant, clindamycin-sensitive staphylococcal strains isolated from clinical specimens. Material and Method: A total of 108 erythromycin-resistant, clindamycin-sensitive staphylococcal isolates from various clinical specimens were tested using D-test according to CLSI guidelines. Result: A total of 23 (21.3%) staphylococcal isolates were found to be D-test positive and demonstrated inducible clindamycin resistance (iMLSB phenotype). MRSA isolates showed highest percentage (25.8%) of inducible clindamycin resistant phenotypes. Conclusion: Inducible clindamycin resistance should be checked in staphylococcal isolates before administering clindamycin therapy in staphylococcal infections as it can lead to clinical failure.Keywords
D-test, MRSA, iMLSB Phenotype , Clindamycin, erm Methylase.
References
- K Prabhu,S Rao,V Rao. Inducible clindamycin resistance in staphylococcus aureus isolated from clinical samples. Journal of Laboratory Physicians, 2011; 3 (1): 25-27
- Yilmaz G, Aydin K, Iskender S, Caylan R and Koksal I. Detection andprevalence of inducible clindamycin resistance in staphylococci. Journal of Medical Microbiology. 2007; 56: 342-345.
- Deotale V, Mendiratta DK, Raut U, Narang P. Inducible clindamycin resistance in staphylococcus aureus isolated from clinical samples. Indian Journal of Medical Microbiology. 2010; 55 (2): 124-126
- Fiebelkorn KR,Crawford SA, McElmeel ML, Jorgensen JH. Practical disc diffusion method for detection of inducible clindamycin resistance in staphylococcus aureus and coagulase- negative staphylococci. J Clin Microbiol. 2003; 41: 4740-4744.
- Ciraj AM, Vinod P, Sreejith G et al. Inducible clindamycin resistance among clinical isolates of staphylococci. Indian J Pathol Microbiol. 2009; 52: 49-51.
- Leclercq R. Mechanisms of resistance to macrolides and lincosamides. Clin Infect Dis. 2002; 34: 482–492.
- Date K, Choudhary M, Thambare V. International Journal of Biological & Medical Research. 2012; 3 (3): 1922-1925.
- Roberts MC, Sutcliffe J, Courvalin P, Jensen LB, Rood J, Seppala H. Nomenclature for macrolidelincosamide– streptogramin B resistance determinants. Antimicrob Agents Chemother. 1999; 43: 2823–2830.
- Woods CR. The Pediatric Infectious Disease Journal. 2009; 28 (12): 1115-1118.
- Catchpole I, Dyke KGH. A Staphylococcus aureus plasmid that specifies constitutive macrolide-licosamide-streptogramin B resistance contains a novel deletion in erm C attenuator. FEMS Microbiol Lett. 1990; 69: 43-48.
- Werckenthin, C, Schwarz S , Westh, H. Structural alterations in the translational attenuator of constitutively expressed erm C genes . Antimicrob Agents Chemother.1999; 43: 1681– 1685.
- Daurel C, Huet C, Dhalluin A, et al. Differences in potential for selection of clindamycin-resistant mutants between inducible erm(A) and erm(C) Staphylococcus aureus genes. J Clin Microbiol. 2008; 46: 546 –550.
- Lewis JS II, Jorgensen JH. Inducible Clindamycin Resistance in Staphylococci: Should Clinicians and Microbiologists be Concerned? Clinical Infectious Diseases. 2005; 40: 280–285.
- Jorgensen JH, Crawford SA, McElmeel ML, Fiebelkorn KR. Detection of inducible clindamycin resistance of staphylococci in conjunction with performance of automated broth susceptibility testing. J Clin Microbiol. 2004; 42: 1800–1802.
- Watanakunakorn C. Clindamycin therapy of Staphylococcus aureus endocarditis: Clinical relapse and development of resistance to clindamycin, lincomycin and erythromycin. Am J Med. 1976; 60: 419-425.
- Drinkovic D, Fuller ER, Shore KP, Holland DJ, Ellis-Pegler R. Clindamycin treatment of Staphylococcus aureus expressing inducible clindamycin resistance. J Antimicrob Chemother.2001; 48: 315-316.
- Siberry GK, Tekle T, Carroll K, Dick J. Failure of clindamycin treatment of methicillin resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. Clin Infect Dis 2003; 37: 1257-1260
- Becker K, von Eiff C. Staphylococcus, micrococcus, and other catalase-positive cocci. Manual of clinical microbiology, tenth edition, Washington press, DC, ASM press. 2011; 1: 308- 330.
- Clinical and laboratory standards institute (CLSI). Performance standards for antimicrobial susceptibility testing; twenty-second informational supplement. 2012; M100-S22, 32 (3).
- Stevens DL, Ma Y, Salmi D, et al. Impact of antibiotics on expression of virulence-associated exotoxin genes. J Infect Dis. 2007; 195:202–211.