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Sharma, Shiv
- Food Color Induced Hepatotoxicity in Swiss Albino Rats, Rattus norvegicus
Authors
1 Department of Zoology, Bareilly College, Bareilly, Uttar Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 1 (2015), Pagination: 152-157Abstract
Objective: Certain dietary constituents can induce toxicity and play a critical role in the development of several hepatic disorders. Tartrazine, metanil yellow and sunset yellow are widely used azo dyes in food products, so the present study is aimed to investigate the food color induced hepatotoxicity in Swiss albino rats. Materials and Methods: Swiss albino rats were divided into four groups, each group having six animals. Group I served as control, Group II, Group III and Group IV were administered with 25, 50 and 75 mg/kg body weight blend of sunset yellow, metanil yellow and tartrazine for 30 days. Hepatotoxicity in rats treated with a blend of these food colors was studied by assessing parameters such as serum total protein, serum albumin, serum alkaline phosphatase (ALP) as well as hepatic malondialdehyde (MDA). The activity of superoxide dismutase (SOD), reduced glutathione (GSH) and catalase (CAT) were assessed. Results: Significantly increased concentrations of serum total protein, serum albumin, serum ALP and hepatic MDA and significantly lowered levels of SOD, reduced GSH and CAT in the liver tissue of treated animals were observed when compared with control animals. The alteration in the liver includes necrosis of hepatocytes, infiltration and vacuolation. Conclusion: The result indicates that consumption of food color in diet induces liver tissue damage. The used doses of food color were mostly attributable to hepatocellular damage and drastic alteration in antioxidant defense system.Keywords
Metanil Yellow, Sunset Yellow, Swiss Albino Rat, Tartrazine.
- Application of Taguchi Desirability Function Analysis (TDFA) for Optimizing Multiple Responses in Turning Inconel 718
Authors
1 Mechanical Engineering Department, NERIST, Nirjuli, Arunachal Pradesh, IN
2 Mechanical Engineering Department, SNS College of Technology, Coimbatore, IN
Source
Manufacturing Technology Today, Vol 13, No 6 (2014), Pagination: 20-29Abstract
In this work a new approach of multi response optimization for turning process in Inconel 718 using Taguchi based desirability function analysis (TDFA) is presented. Experiments based on Taguchi L9 orthogonal array (OA) was considered in this study. Three machining parameters viz., cutting speed (v), feed rate (f) and depth of cut (d) are optimized by multi response considerations namely surface roughness (Ra), tool wear (VB), tool life (TL), cutting force (F), cutting power (P) and material removal rate (MRR). The approach obtains composite desirability value for the multiple response using individual desirability values evaluated. The optimum parameters are obtained based on composite desirability value. It is observed that the combination of turning parameters as v = 35 m/min, f = 0.1 mm/rev and d = 1.25 mm (i.e., v2-f1-d2) are obtained as optimal parameters producing Ra, VB, TL, F, P, and MRR respectively as 0.46128 μm, 0.1140 mm, 21.8296 min, 770.135 N, 4.89497 kW, 4375 mm3/min. Confirmation test of the predicted result shows the maximum % error is 6.67.