Informatics Publishing Limited

Manoranjan Sabat ¹, Sharada Nalla ¹, Venkateswarlu Goli ¹, Sravan Prasad Macherla ², Praveena Kumari Matta ², S. Madhu Chandaka ²

Affiliations
1 Venkateswara Institute of Pharmaceutical Seinces, Cherlapally, Nalgonda -508001, IN
2 Sri Indu Institute of Pharmacy, Sheriguda, Ibrahimpatnam, R.R Dist. -501510, IN

Abstract

A sensitive, precise, accurate and simple UV spectrophotometric method has been developed for estimation of ciprofloxacin in bulk and pharmaceutical dosage form. The drug shows maximum absorbance at 273 nm (max). The linearity was observed in the concentration range of 5-50mcg/ml. The proposed method has been applied successfully to the analysis of cited drug in pharmaceutical formulation. Recovery study was performed to confirm the accuracy of the method. The method was validated as per ICH guide lines.

Keywords

Estimation, Ciprofloxacin, UV Spectrophotometer.

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Sharada Nalla ¹, Venkateswarlu Goli ¹, Manoranjan Sabat ¹, Someshwar Komati ¹, M. D. Noorunnisa Begam ¹, Venugopal Rao Kokkirala ¹

Affiliations
1 Venkateswara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda – 508 001, A.P, IN

Abstract

The ethanolic extract of Cassia auriculata L. flower (family Leguminaceae) were tested for type 2 anti-diabetic activity using streptazotocin - nicotinamide induced diabetic rats and compared with standard. The result expressed that ethanolic extract had shown significant protection and maximum reduction in blood glucose was observed in streptazotocin - nicotinamide induced diabetic rats (p>0.05). The result of this comprehensive study reveals that Cassia auriculata flower shown statistically significant type 2 anti-diabetic activity in comparison to the standard glibenclamide.

Keywords

Cassia auriculata, Anti-Diabetic Activity, Streptazotocin, Nicotinamide and Glibenclamide.

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