A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jindal, Shammy
- A Concise Review on Synthesis, Anti-inflammatory and Antioxidant Activities of Chalcone
Authors
1 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 37 - 44Abstract
Chalcones and their derivatives have been an area of great interest in recent years. Numbers of research publications have been published and chalcones continue to show promising effect for new drug investigations. Chalcone is an advantageous species with medicinal importance as it is consisting of highly reactive ketoethylenic system –CO–CH=CH– which belongs to flavonoids. Chalcones (1, 3-Diphenyl-2-propen-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. However, synthesis in laboratory of broad range of chalcones has also been reported. In chalcone and its derivatives, a highly reactive α, β-unsaturated carbonyl system is the major reason for their pharmacological potencies. Chalcones and their derivatives are known to show a wide range of pharmacological potencies such as anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antigout, antihistaminic, antiviral, antimycobacterial etc. Chalcones can be prepared by Claisen– Schmidt’s condensation, Aldol condensation, Heck’s reaction, Suzuki’s reaction, Ultrasound method of synthesis, Solvent free synthesis of chalcones, One pot synthesis, Sonogashira Isomerization coupling reaction etc. The purpose of the present review is to focus on the various methods of preparation of chalcones and derivatives and their anti-inflammatory and antioxidant potencies.
Keywords
Chalcone, Claisen–Schmidt condensation, Aldol condensation, anti-inflammatory, antioxidantReferences
- Awasthi SK, Mishra N, Kumar B, Sharma M, Bhattacharya A, Mishra LC, Bhasin VK. Potent antimalarial activity of newly synthesized substituted chalcone analogs in vitro. Medicinal Chemistry Research. 2009;18(6):407-20.
- Cheng MS, Li RS, Kenyon G. A solid phase synthesis of chalcones by Claisen-Schmidt condensations. Chinese Chemical Letters. 2000;11(10):851-4.
- Liu M, Wilairat P, Go ML. Antimalarial alkoxylated and hydroxylated chalones: structure− activity relationship analysis. Journal of Medicinal Chemistry. 2001;44(25):4443-52.
- Straub TS. Epoxidation of α, β-unsaturated ketones with sodium perborate. Tetrahedron letters. 1995;36(5):663-4.
- Dhar R, Kimseng R, Chokchaisiri R, Hiransai P, Utaipan T, Suksamrarn A, Chunglok W . 2′, 4-Dihydroxy-3′, 4′, 6′-trimethoxychalcone from Chromolaena odorata possesses anti-inflammatory effects via inhibition of NF-κB and p38 MAPK in lipopolysaccharide-activated RAW 264.7 macrophages. Immunopharmacology and Immunotoxicology. 2018;40(1):43-51.
- Fu ZY, Jin QH, Qu YL, Guan LP. Chalcone derivatives bearing chromen or benzo [f] chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities. Bioorganic & Medicinal Chemistry Letters. 2019;29(15):1909-12.
- Gan FF, Zhang R, Ng HL, Karuppasamy M, Seah W, Yeap WH, Ong SM, Hadadi E, Wong SC, Chui WK, Chew EH. Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway. Food and Chemical Toxicology. 2018;116:238-48.
- LiJ,LiD,XuY,GuoZ,LiuX,YangH,WuL,WangL.Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 2017;27(3):602-6.
- Mahapatra DK, Bharti SK, Asati V . Chalcone derivatives: anti- inflammatory potential and molecular targets perspectives. Current Topics in Medicinal Chemistry. 2017;17(28):3146-69.
- Idris MM, Amin SM, Selvaraj M, Jamari H, Kek TL, Salleh MZ. High-Throughput Structure-Based Drug Design of Chalcones Scaffolds as Dual Inhibitor of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1. Journal of Pharmaceutical Sciiences and Emerging Drugs. 2018;6(01).
- Sayed M, Kamal El‐Dean AM, Ahmed M, Hassanien R. Synthesis, Characterization, and Screening for Anti‐inflammatory and Antimicrobial Activity of Novel Indolyl Chalcone Derivatives. Journal of Heterocyclic Chemistry. 2018;55(5):1166-75.
- Bandgar BP, Patil SA, Gacche RN, Korbad BL, Hote BS, Kinkar SN, Jalde SS. Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents. Bioorganic & Medicinal Chemistry Letters. 2010;20(2):730-3.
- Goyal K, Kaur R, Goyal A, Awasthi R. Chalcones: A review on synthesis and pharmacological activities. Journal of Applied Pharmaceutical Science. 2021;1(Supp 1):001–014.
- Pingaew R, Saekee A, Mandi P, Nantasenamat C, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. Synthesis, biological evaluation and molecular docking of novel chalcone–coumarin hybrids as anticancer and antimalarial agents. European Journal of Medicinal Chemistry. 2014;85:65-76.
- Baviskar B, Patel S, Baviskar B, Khadabadi SS, Shiradkar M. Design and synthesis of some novel chalcones as potent antimicrobial agent. Asian Journal of Research in Chemistry. 2008;1(2):67-9.
- Al-Mosawi SK, Al-Hazam HA, Abbas AF. Synthesis, Characterization and Biological Study of Some Chalcones derived from Terphthaldehyde. Asian Journal of Research in Chemistry. 2019;12(3):153-6.
- Benouda H, Bouchal B, Challioui A, Oulmidi A, Harit T, Malek F, Riahi A, Bellaoui M, Bouammali B. Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities. Letters in Drug Design & Discovery. 2019;16(1):93-100.
- Lal K, Yadav P, Kumar A, Kumar A, Paul AK. Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1, 2, 3-triazole hybrids. Bioorganic chemistry. 2018;77:236-44.
- Monga V, Goyal K, Steindel M, Malhotra M, Rajani DP, Rajani SD. Synthesis and evaluation of new chalcones, derived pyrazoline and cyclohexenone derivatives as potent antimicrobial, antitubercular and antileishmanial agents. Medicinal Chemistry Research. 2014;23(4):2019-32.
- Mokle SS, Sayyed MA, Vibhute AY, Khansole SV, Nalwar YS, Vibhute YB. Synthesis of Some New Bioactive Chalcones and Flavones. Research Journal of Pharmacy and Technology. 2009;2(4):846-9.
- Shahare HV, Pawar GR, Patil SS, Patil PD. Synthesis and Biological Evaluation of New Chalcone Analogs. Asian Journal of Research in Chemistry. 2011;4(2):237-40.
- Lunkad AS, Kothawade SN, Jadhav DV, Chaudhari PS, Bornare SP. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research Journal of Pharmacy and Technology. 2015;8(3):276.
- Bhat KI and Kumar A. Synthesis and Biological Evaluation of Some Novel Pyrazoline Derivatives Derived from Chalcones. Research Journal of Pharmacy and Technology. 2017;10(5):1344-1346.
- Dawane BS, Shaikh BM, Khandare NT, Mandawad GG, Chobe SS, Konda SG. Synthesis of Some Novel Substituted Pyrazole Based Chalcones and Their In-Vitro Antimicrobial Activity. Asian Journal of Research in Chemistry. 2010;3(1):90-3.
- Narwal S, Kumar S, Verma PK. Synthesis and biological activity of new chalcone scaffolds as prospective antimicrobial agents. Research on Chemical Intermediates. 2021;47:1625–1641
- Prabhakar V , Babu KS, Ravindranath LK, Basha MS, Latha J. Application of Chalcones in Synthesis of Novel 1, 5-Benzodiazepine Derivatives Containing Thieno [2, 3-d] Pyrimidine Core Unit and its Biological Activity Screening. Asian Journal of Research in Chemistry. 2017;10(2):71-84.
- Beena KP, Rajesh P, Nathiya S. Synthesis of some novel substituted isoxazoline based chalcones and their in-vitro antimicrobial activity. Asian Journal of Research in Chemistry. 2010;3(4):1080-2.
- Özdemir A, Altıntop MD, Sever B, Gençer HK, Kapkaç HA, Atlı Ö, Baysal M. A new series of pyrrole-based chalcones: synthesis and evaluation of antimicrobial activity, cytotoxicity, and genotoxicity. Molecules. 2017;22(12):2112.
- Singh PP, Jayalakshmi B, Kumar NS. Synthesis, Characterization and Antimicrobial Evaluation of Some New Chalcones. Asian Journal of Research in Chemistry. 2013;6(12):1133-6.
- Wan Z, Hu D, Li P, Xie D, Gan X. Synthesis, antiviral bioactivity of novel 4-thioquinazoline derivatives containing chalcone moiety. Molecules. 2015;20(7):11861-74.
- Padaratz P, Fracasso M, De Campos‐Buzzi F, Corrêa R, Niero R, Monache FD, Cechinel‐Filho V. Antinociceptive activity of a new benzofuranone derived from a chalcone. Basic & Clinical Pharmacology & Toxicology. 2009;105(4):257-61.
- Rossi GV, Avellino JD. An evaluation of the antihistaminic activity of a new series of chalcone derivatives. American Journal of Pharmacy and the Sciences Supporting Public Health. 1957;129(9):324-31.
- N Choudhary A, Kumar A, Juyal V. Design, synthesis and evaluation of chalcone derivatives as anti-inflammatory, antioxidant and antiulcer agents. Letters in Drug Design & Discovery. 2012;9(5):479-88.
- Balu P, Jas JS, Govindaraj M. Design and evaluation of chalconeimine derivatives as α-amylase inhibitors. Bioinformation. 2019;15(7):523.
- Emayavaramban M, Santhi N, Gopi C, Manivannan C, Raguraman A. Synthesis, Characterization and Anti-diabetic activity of 1, 3, 5-triaryl- 2-pyrazolines in acetic acid solution under Ultrasound Irradiation. International Letters of Chemistry, Physics and Astronomy. 2013;9:172-85.
- Gaur R, Yadav KS, Verma RK, Yadav NP, Bhakuni RS. In vivo anti- diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine. 2014;21(4):415-22.
- Hsieh CT, Hsieh TJ, El-Shazly M, Chuang DW, Tsai YH, Yen CT, Wu SF, Wu YC, Chang FR. Synthesis of chalcone derivatives as potential anti-diabetic agents. Bioorganic & Medicinal Chemistry Letters. 2012;22(12):3912-5.
- Rammohan A, Reddy JS, Sravya G, Rao CN, Zyryanov GV. Chalcone synthesis, properties and medicinal applications: a review. Environmental Chemistry Letters. 2020;18(2):433-58.
- Shukla P, Satyanarayana M, Verma PC, Tiwari J, Dwivedi AP, Srivastava R, Rehuja N, Srivastava SP, Gautam S, Tamrakar AK, Dwivedi AK. Chalcone-based aryloxypropanolamine as a potential antidiabetic and antidyslipidaemic agent. Current Science. 2017:1675- 89.
- Hsieh CY, Ko PW, Chang YJ, Kapoor M, Liang YC, Chu HL, Lin HH, Horng JC, Hsu MH. Design and synthesis of benzimidazole-chalcone derivatives as potential anticancer agents. Molecules. 2019;24(18):3259.
- Khanapure S, Jagadale M, Bansode P, Choudhari P, Rashinkar G. Anticancer activity of ruthenocenyl chalcones and their molecular docking studies. Journal of Molecular Structure. 2018;1173:142-7.
- Sashidhara KV, Kumar A, Kumar M, Sarkar J, Sinha S. Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters. 2010;20(24):7205-11.
- Sharma A, Anghore D, Awasthi R, Kosey S, Jindal S, Gupta N, Raj D, Sood R. A Review on Current Carbon Nanomaterials and Other Nanoparticles Technology and Their Applications in Biomedicine. World Journal Pharmacy and Pharmaceutical Science. 2015;4(12):1088-113.
- Hofmann E, Webster J, Do T, Kline R, Snider L, Hauser Q, Higginbottom G, Campbell A, Ma L, Paula S. Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers. Bioorganic & Medicinal Chemistry. 2016;24(4):578-87.
- Insuasty B, Ramírez J, Becerra D, Echeverry C, Quiroga J, Abonia R, Robledo SM, Vélez ID, Upegui Y, Muñoz JA, Ospina V. An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo [3, 4-b][1, 4] diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents. European Journal of Medicinal Chemistry. 2015;93:401-13.
- K Sahu N, S Balbhadra S, Choudhary J, V Kohli D. Exploring pharmacological significance of chalcone scaffold: a review. Current Medicinal Chemistry. 2012;19(2):209-25.
- Higuchi K, Watanabe T, Tanigawa T, Tominaga K, Fujiwara Y, Arakawa T. Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Helicobacter pylori: A randomized controlled comparative trial with cimetidine, an H2‐receptor antagonist. Journal of Gastroenterology and Hepatology. 2010;25:S155-60.
- Weindorf N, Schultz-Ehrenburg U. Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone. Zeitschrift fur Hautkrankheiten. 1987;62(1):28-38.
- Beltramino R, Penenory A, Buceta AM. A open-label, randomised multicentre study comparing the efficacy and safety of CYCLO 3 FORT versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. International Angiology. 1999;18(4):337.
- Beltramino R, Penenory A, Buceta AM. An open-label, randomized multicenter study comparing the efficacy and safety of Cyclo 3 Fort® versus hydroxyethyl rutoside in chronic venous lymphatic insufficiency. Angiology. 2000;51(7):535-44.
- Liu Y, Lund JA, Murch SJ, Brown PN. Single-lab validation for determination of kavalactones and flavokavains in Piper methysticum (Kava). Planta Medica. 2018;84(16):1213-8.
- Pinner KD, Wales CT, Gristock RA, Vo HT, So N, Jacobs AT. Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes. Pharmaceutical Biology. 2016;54(9):1503-12.
- Echeverria C, Santibañez JF, Donoso-Tauda O, Escobar CA, Ramirez- Tagle R. Structural antitumoral activity relationships of synthetic chalcones. International Journal of Molecular Sciences. 2009;10(1):221-31.
- Kolot C, Rodriguez-Mateos A, Feliciano R, Bottermann K, Stahl W. Bioavailability of naringenin chalcone in humans after ingestion of cherry tomatoes. International Journal for Vitamin and Nutrition Research. 2019; 90(5–6):411–6.
- Slimestad R, Verheul M. Properties of chalconaringenin and rutin isolated from cherry tomatoes. Journal of Agricultural and Food Chemistry. 2011;59(7):3180-5.
- Gerhauser C. Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Medica. 2008;74(13):1608-24.
- Mariadoss AV, Vinyagam R, Rajamanickam V, Sankaran V, Venkatesan S, David E. Pharmacological aspects and potential use of phloretin: A systemic review. Mini Reviews in Medicinal Chemistry. 2019;19(13):1060-7.
- MinJ,LiX,HuANGKE,TangH,DingX,QiC,QinX,XuZH. Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways. Oncology Reports. 2015;34(6):2871-9.
- Reiland H, Slavin J. Systematic review of pears and health. Nutrition Today. 2015;50(6):301.
- Sasaki C, Ichitani M, Kunimoto KK, Asada C, Nakamura Y. Extraction of arbutin and its comparative content in branches, leaves, stems, and fruits of Japanese pear Pyrus pyrifolia cv. Kousui. Bioscience, Biotechnology, and Biochemistry. 2014;78(5):874-7.
- Vashishtha M, Mishra M, Shah DO. Study on catalytic property of NaOH-cationic surfactant solutions for efficient, green and selective synthesis of flavanone. Journal of Molecular Liquids. 2015;210:151-9.
- Sharma R, Kumar K, Chouhan M, Grover V, Nair VA. Lithium hydroxide mediated synthesis of 3, 4-disubstituted pyrroles. RSC Advances. 2013;3(34):14521-7.
- Yang W, Miao T, Li P, Wang L. Regioselective synthesis of triazoles via base-promoted oxidative cycloaddition of chalcones with azides in aqueous solution. RSC Advances. 2015;5(116):95833-9.
- Sie CZ, Ngaini Z, Suhaili N, Madiahlagan E. Synthesis of kojic ester derivatives as potential antibacterial agent. Journal of Chemistry. 2018;2018.
- Miyahara Y, Ito YN. AlCl3-mediated aldol cyclocondensation of 1, 6- and 1, 7-diones to cyclopentene and cyclohexene derivatives. The Journal of Organic Chemistry. 2014;79(15):6801-7.
- Ritter M, Martins RM, Rosa SA, Malavolta JL, Lund RG, Flores AF, Pereira CM. Green synthesis of chalcones and microbiological evaluation. Journal of the Brazilian Chemical Society. 2015;26(6):1201-10.
- Liu F, Yang JF, Liu H, Wei WZ, Ma YM. Facile Microwave‐assisted Synthesis of 1, 3, 5‐Trisubstituted Pyrazoline Derivatives Incorporating Sulfonyl Moiety. Journal of the Chinese Chemical Society. 2016;63(3):254-60.
- Nimkar A, Ramana MM, Betkar R, Ranade P, Mundhe B. CsOH/γ- Al2O3: A heterogeneous reusable basic catalyst for one-pot synthesis of 2-amino-4, 6-diaryl pyrimidines. New Journal of Chemistry. 2016;40(3):2541-6.
- Rafiee E, Rahimi F. A green approach to the synthesis of chalcones via Claisen-Schmidt condensation reaction using cesium salts of 12- tungstophosphoric acid as a reusable nanocatalyst. Monatshefte für Chemie-Chemical Monthly. 2013;144(3):361-7.
- Rafiee E, Rahimi F. Synthesis of biologically active chalcon analogues via Claisen-Schmidt Condensation in solvent-free conditions: supported mixed addenda heteropoly acid as a heterogeneous catalyst. Journal of the Chilean Chemical Society. 2013;58(3):1926-9.
- Sathiyamoorthi K, Mala V, Sakthinathan SP, Kamalakkannan D, Suresh R, Vanangamudi G, Thirunarayanan G. Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl E 2- propen-1-ones. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2013;112:245-56.
- Sinhamahapatra A, Pal P, Tarafdar A, Bajaj HC, Panda AB. Mesoporous borated zirconia: a solid acid–base bifunctional catalyst. ChemCatChem. 2013;5(1):331-8.
- Sultan A, Raza AR, Abbas M, Khan KM, Tahir MN, Saari N. Evaluation of silica-H2SO4 as an efficient heterogeneous catalyst for the synthesis of chalcones. Molecules. 2013;18(8):10081-94.
- Morrison RT, Boyd RN. Organic Chemistry, 6th edn., Pearson Education Publishers. 2004; 971–990, 997–1020
- Eddarir S, Cotelle N, Bakkour Y, Rolando C. An efficient synthesis of chalcones based on the Suzuki reaction. Tetrahedron Letters. 2003;44(28):5359-63.
- Selepe MA, Van Heerden FR. Application of the Suzuki-Miyaura reaction in the synthesis of flavonoids. Molecules. 2013;18(4):4739-65.
- Bianco A, Cavarischia C, Farina A, Guiso M, Marra C. A new synthesis of flavonoids via Heck reaction. Tetrahedron Letters. 2003;44(51):9107-9.
- Jagdale AR, Sudalai A. p-Toluenesulfonic acid mediated hydroarylation of cinnamic acids with anisoles and phenols under metal and solvent-free conditions. Tetrahedron Letters. 2007;48(28):4895-8.
- Abe I, Sano Y, Takahashi Y, Noguchi H. Site-directed mutagenesis of benzalacetone synthase: the role of Phe215 in plant type III polyketide synthases. Journal of Biological Chemistry. 2003;278(27):25218-26. 80. Rothenberg G, Downie AP, Raston CL, Scott JL. Understanding solid/solid organic reactions. Journal of the American Chemical Society. 2001;123(36):8701-8.
- Siddiqui ZN. A convenient synthesis of coumarinyl chalcones using HClO4–SiO2: A green approach. Arabian Journal of Chemistry. 2019;12(8):2788-97.
- Rajesh UC, Purohit G, Rawat DS. One-pot synthesis of aminoindolizines and chalcones using CuI/CSP nanocomposites with anomalous selectivity under green conditions. ACS Sustainable Chemistry & Engineering. 2015;3(10):2397-404.
- Wei W, Qunrong W, Liqin D, Aiqing Z, Duoyuan W. Synthesis of dinitrochalcones by using ultrasonic irradiation in the presence of potassium carbonate. Ultrasonics Sonochemistry. 2005;12(6):411-4.
- Adole VA, Jagdale BS, Pawar TB, Sagane AA. Ultrasound promoted stereoselective synthesis of 2, 3-dihydrobenzofuran appended chalcones at ambient temperature. South African Journal of Chemistry. 2020;73:35-43.
- Calvino V, Picallo M, López-Peinado AJ, Martín-Aranda RM, Durán- Valle CJ. Ultrasound accelerated Claisen–Schmidt condensation: A green route to chalcones. Applied Surface Science. 2006;252(17):6071- 4.
- Cancio N, Costantino AR, Silbestri GF, Pereyra MT. Ultrasound- Assisted Syntheses of Chalcones: Experimental Design and Optimization. InMultidisciplinary Digital Publishing Institute Proceedings 2019 (Vol. 41, No. 1, p. 13).
- Li JT, Yang WZ, Wang SX, Li SH, Li TS. Improved synthesis of chalcones under ultrasound irradiation. Ultrasonics Sonochemistry. 2002;9(5):237-9.
- Polo E, Ibarra-Arellano N, Prent-Peñaloza L, Morales-Bayuelo A, Henao J, Galdámez A, Gutiérrez M. Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. Bioorganic Chemistry. 2019;90:103034.
- Braun RU, Ansorge M, Müller TJ. Coupling–Isomerization synthesis of chalcones. Chemistry–A European Journal. 2006;12(35):9081-94.
- Won SJ, Liu CT, Tsao LT, Weng JR, Ko HH, Wang JP, Lin CN. Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents. European Journal of Medicinal Chemistry. 2005;40(1):103-12.
- Zhao F, Nozawa H, Daikonnya A, Kondo K, Kitanaka S. Inhibitors of nitric oxide production from hops (Humulus lupulus L.). Biological and Pharmaceutical Bulletin. 2003;26(1):61-5.
- Ito Y, Miyake Y, Okada K, inventors Maruzen Pharmaceuticals Co. Ltd., assignee. Reduced chalcone compound and method of producing the same, reduced product of fat-soluble licorice root extract and method of producing the same, cyclooxygenase-2 activity inhibitor, whitening agent, antiinflammatory agent and cosmetic. WO. 2007;2007052330:A1.
- Bano S, Javed K, Ahmad S, Rathish IG, Singh S, Chaitanya M, Arunasree KM, Alam MS. Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity. European Journal of Medicinal Chemistry. 2013;65:51-9.
- ozdemir A, Altıntop MD, Turan-Zitouni G, Çiftçi GA, Ertorun İ, Alataş o, Kaplancıklı ZA. Synthesis and evaluation of new indole- based chalcones as potential antiinflammatory agents. European Journal of Medicinal Chemistry. 2015;89:304-9.
- Bandgar BP, Hote BS, Dhole NA, Gacche RN. Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties. Medicinal Chemistry Research. 2012;21(9):2292-9.
- Jadhav SY, Bhosale RB, Shirame S, Sonawane VD, Hublikar MG, Sonawane KD, Shaikh RU. Synthesis and biological evaluation of fluoro-hydroxy substituted pyrazole chalcones as anti-inflammatory, antioxidant and antibacterial agents. International Journal of Pharma and Bio Sciences. 2013;4(2):390–397.
- Nyandoro SS, Nkunya MH, Josepha CC, Odalo JO, Sattler I. New Glucopyranosylglyceryl-N-Octenyl Adipate and Bioactivity of Retro and Condensed Chalcones from Toussaintia Orientalis. Tanzania Journal of Science. 2012;38(3):108-26.
- Yadav HL, Gupta P, Pawar RS, Singour PK, Patil UK. Synthesis and biological evaluation of anti-inflammatory activity of 1, 3 diphenyl propenone derivatives. Medicinal Chemistry Research. 2011;20(4):461-5.
- Jantan I, Bukhari SN, Adekoya OA, Sylte I. Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines. Drug Design, Development and Therapy. 2014;8:1405.
- Bukhari SN, Ahmad W, Butt AM, Ahmad N, Amjad MW, Hussain MA, Shah VH, Trivedi AR. Synthesis and evaluation of chalcone analogues and pyrimidines as cyclooxygenase (COX) inhibitors. African Journal of Pharmacy and Pharmacology. 2012;6(14):1064-8.
- Zhang XW, Zhao DH, Quan YC, Sun LP, Yin XM, Guan LP. Synthesis and evaluation of anti-inflammatory activity of substituted chalcone derivatives. Medicinal Chemistry Research. 2010;19(4):403- 12.
- Hasan SA, Elias AN, Jwaied AH, Khuodaer AR, Hussain SA. Synthesis of new fluorinated chalcone derivative with anti- inflammatory Activity. International Journal of Pharmacy and Pharmaceutical Sciences. 2012;4(5):430-4.
- Akhtar MS, Rehman AU, Arshad H, Malik A, Fatima M, Tabassum T, Raza AR, Bukhsh M, Murtaza MA, Mehmood MH, Sultan A. In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats. Dose-Response. 2021;19(1):1559325821996955.
- Aly MR, Fodah HH, Saleh SY. Antiobesity, antioxidant and cytotoxicity activities of newly synthesized chalcone derivatives and their metal complexes. European Journal of Medicinal Chemistry. 2014;76:517-30.
- Sivakumar PM, Prabhakar PK, Doble M. Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones. Medicinal Chemistry Research. 2011;20(4):482-92.
- Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR. Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro. Journal of Agricultural and Food Chemistry. 2000;48(9):3876-84.
- Kumar CS, Loh WS, Ooi CW, Quah CK, Fun HK. Structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential. Molecules. 2013;18(10):11996-2011.
- Lahsasni SA, Al Korbi FH, Aljaber NA. Synthesis, characterization and evaluation of antioxidant activities of some novel chalcones analogues. Chemistry Central Journal. 2014;8(1):1-10.
- Qian YP, Shang YJ, Teng QF, Chang J, Fan GJ, Wei X, Li RR, Li HP, Yao XJ, Dai F, Zhou B. Hydroxychalcones as potent antioxidants: structure–activity relationship analysis and mechanism considerations. Food Chemistry. 2011;126(1):241-8.
- Murti Y, Goswam A, Mishra P. Synthesis and antioxidant activity of some chalcones and flavanoids. International Journal of PharmTech Research. 2013;5:811-8.
- Recent Updates on Psoriasis: A Review
Authors
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 76 - 83Abstract
In the past 15 years, breakthroughs in the understanding towards the pathogenesis of psoriasis have been translated into highly and targeted effective therapies which provides fundamental insights into the pathogenesis of chronic inflammatory diseases. In this article we understand the mechanisms involved in the initiation and development of psoriasis, as well as the therapeutic options that arises from the dissection of the inflammatory psoriatic pathways. The whole discussion begins by addressing the inflammatory pathways and key cell types which initiating and perpetuating the psoriatic inflammation. Also, we discuss the role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis. So, we the purpose of our study is to understand psoriasis comprehensively, and this review is well-established to explain the therapies, and other novel targeted drugs that are mostly used in the effective treatment of psoriasis.
Keywords
Psoriasis, Types, Pathogenesis, Epidemiology, PharmacotherapyReferences
- Mabuchi T, Chang TW, Quinter S and Hwang ST. Chemokine receptors in the pathogenesis and therapy of psoriasis. Journal of Dermatological Science. 2012;65(1): 4-11
- Tsuruta D. NF-κB links keratinocytes and lymphocytes in the pathogenesis of psoriasis. Recent Patents on Inflammation and Allergy Drug Discovery. 2009; 3(1): 40-8.
- Krueger JG and Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Annals of the Rheumatic Diseases 2005; 64(2): 30-6.
- Sondhi S, Singh N, Jindal S. Natural Remedies used in the Treatment of Psoriasis: A short Review. Asian Journal of Pharmaceutical Research. 2021;11(1):43-5.
- Nograles KE and Krueger JG. Anti-cytokine therapies for psoriasis. Experimental Cell Research. 2011; 317(9): 1293-300.
- Galimova ES, Akhmetova VL and Khusnutdinova EK. Molecular genetic basis of susceptibility to psoriasis. Russian Journal of Genetics. 2008; 44(5): 513.
- Campalani E and Barker JN. The clinical genetics of psoriasis. Current Genomics. 2005; 6(1): 51-60.
- A Kumar, S Jindal, MS Ashawat, V Pandit, V Priya. Psoriasis and Its Treatment: A Review.
- Vani PB, Kumar PR. A Comparative Review on Conventional and Traditional medicine in the Treatment of Psoriasis. Research Journal of Pharmacy and Technology. 2020;13(11):5642-6.
- Lebwohl M, Menter A, Koo J and Feldman SR. Combination therapy to treat moderate to severe psoriasis. Journal of the American Academy of Dermatology. 2004; 50(3): 416-30.
- Armstrong AW, Schupp C, Wu J and Bebo B. Quality of life and work productivity impairment among psoriasis patients: findings from the National Psoriasis Foundation survey data 2003–2011. PloS one. 2012; 7(12): e52935.
- Weiss SC, Kimball AB, Liewehr DJ, Blauvelt A and Turner ML. Quantifying the harmful effect of psoriasis on health-related quality of life. Journal of the American Academy of Dermatology 2002; 47(4): 512-8.
- Kimball AB, Gieler U, Linder D, Sampogna F and Warren RB: 33. Psoriasis: is the impairment to a patient’s life cumulative? Journal of the European Academy of Dermatology and Venereology. 2010; 24(9): 989-04. 34.
- Azfar RS, Seminara NM, Shin DB, Troxel AB and Margolis DJ. Increased risk of diabetes mellitus and the likelihood of receiving diabetes mellitus treatment in patients with psoriasis. Archives of Dermatology. 2012; 148(9): 995-00. 35.
- Iriventi P, Gupta NV. Formulation and Evaluation of herbal cream for treating psoriasis. Research Journal of Pharmacy and Technology. 2021;14(1):167-70.
- Gisondi P and Girolomoni G. Cardiometabolic comorbidities and the approach to patients with psoriasis. Actas Dermo- Sifiliograficas. 2009; 100: 14-21.
- Paller AS, Mercy K, Kwasny MJ, Choon SE and Cordoro KM. 37. Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study. JAMA Dermatology. 2013; 149(2): 166-76.
- Parisi R, Symmons DP, Griffiths CE and Ashcroft DM. Global 38. epidemiology of psoriasis: a systematic review of incidence and prevalence. Journal of Investigative Dermatology. 2013; 133: 377- 85. 286-92.
- Pradhan M, Alexander A. Development and Validation of a 39. Robust RP-HPLC Method for Analysis of Calcipotriol in Pharmaceutical Dosage Form. Research Journal of Pharmacy and Technology. 2019;12(2):579-83.
- Bedi TR. Clinical profile of psoriasis in North India. Indian Journal of Dermatology, Venereology and Leprology. 1995; 61(4): 202.
- Kaur I, Handa S and Kumar B. Natural history of psoriasis: a study from the Indian subcontinent. The Journal of Dermatology. 1997; 24(4): 230-4.
- Gillard SE and Finlay AY. Current management of psoriasis in the United Kingdom: patterns of prescribing and resource use in primary care. International Journal of Clinical Practice. 2005; 59(11): 1260-7.
- Rawat Singh M, Pradhan K and Singh D. Lipid matrix systems with emphasis on lipid microspheres: potent carriers for transcutaneous delivery of bioactives. Current Drug Delivery. 2012; 9(3): 243-54.
- Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. Journal of Controlled Release. 2001; 73(2- 3): 137-72.
- Kaplan FO, Daniel H and Barker J: Mechanisms of Disease: Psoriasis. Nestle In: New England Journal of Medicine. 2009; 361(5): 496-09.
- Christophers E, Segaert S, Milligan G, Molta CT and Boggs R: Clinical improvement and satisfaction with biologic therapy in patients with severe plaque psoriasis: results of a European cross- sectional observational study. Journal of Dermatological Treatment. 2013; 24(3): 193-8.
- Chaurasia V, Pal S. Skin diseases prediction: binary classification machine learning and multi model ensemble techniques. Research Journal of Pharmacy and Technology. 2019;12(8):3829-32.
- Pietrzak AT, Zalewska A, Chodorowska G, Krasowska D and Michalak-Stoma A. Cytokines and anticytokines in psoriasis. Clinica Chimica Acta. 2008; 394(1-2): 7-21.
- Raychaudhuri SP and Gross J: A comparative study of pediatric- onset psoriasis with adult-onset psoriasis. Pediatric Dermatology. 2000; 17(3): 174-8.
- Yadav K, Singh D, Singh MR. Development and characterization of corticosteroid loaded lipid carrier system for psoriasis. Research Journal of Pharmacy and Technology. 2021;14(2):966-70.
- D'souza JI, More HN. Topical anti-inflammatory gels of fluocinolone acetonide entrapped in eudragit based microsponge delivery system. Research Journal of Pharmacy and Technology. 2008; 1(4):502-6.
- Kavitha S. Pharmacognostical Evaluation and Standardisation of Ayurvedic Formulation Patoladi Kwatha Churna for Psoriasis. Research Journal of Pharmacy and Technology. 2020; 13(3): 1171-4.
- Wozel G: Psoriasis treatment in difficult locations: scalp, nails, and intertriginous areas. Clinics in Dermatology. 2008; 26(5): 448- 59.
- Mahajan Tejasavi, Singh Navdeep, Goyal Kamya, Pandit Vinay, Ashawat M.S., Jindal Shammy. World dendrimer as a potential drug delivery system: a review. Journal of Pharmacy and Pharmaceutical Sciences. 2021; 10 (4): 1818-1827
- Jindal S, Awasthi R, Singare D, Kulkarni GT. Andrographolide loaded topical nanocarriers for management of psoriasis: a safe and effective approach. Plant Archives. 2021; 21(1):1899-902.
- Krishnamurthy K, Walker A, Gropper CA and Hoffman C. To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection. Journal of Drugs in Dermatology. 2010; 9(3): 241-50.
- Jindal S, Awasthi R, Singare D, Kulkarni GT. Preparation and in vitro evaluation of Tacrolimus loaded liposomal vesicles by two methods: A comparative study. Journal of Research in Pharmacy. 2021, 25(1): 34-41.
- Singh N, Sondhi S, Jindal S, Pandit V, Ashawat MS. Treatment and Management for patients with mild to severe Psoriasis: A Review. Asian Journal of Pharmaceutical Research. 2020; 10(4):286-92.
- Nandgude TD, Hasabe PS, Kolsure AK. Clinical Features and Treatment of Rheumatoid Arthritis: A Review. Research Journal of Pharmacy and Technology. 2018;11(12):5701-6.
- Kumar A, Goyal K, Pandit V , Ashawat MS, Jindal S. Simultaneous estimation of Halobetasol propionate and Tazarotene in pure and dosage form by using UV-Visible Spectrophotometric method. Research Journal of Pharmacy and Technology. 2020; 13(10): 4711-4.
- Jindal S, Awasthi R, Singhare D, Kulkarni GT. Topical delivery of Tacrolimus using liposome containing gel: An emerging and synergistic approach in management of psoriasis. Medical Hypotheses. 2020; 142:109838.
- Sondhi S, Singh N, Goyal K, Jindal S. A Laconic Review on Extraction, Biological Activities of Herbal Formulations of Berberine: A Traditional Drug. Journal of Drug Delivery and Therapeutics. 2020;10(5):345-57.
- Singh N, Goyal K, Sondhi S, Jindal S. Traditional and medicinal use of Barbaloin: potential for the management of various diseases. Journal of Applied Pharmaceutical Research. 2020; 8(3):21-30.
- Mrowietz U, Kragballe K, Reich K, Spuls P and Griffiths CE: Definition of treatment goals for moderate to severe psoriasis: a European consensus. Archives of Dermatological Research. 2011; 303(1): 1-0.
- Singh N, Goyal K, Sondhi S, Jindal S. Development and Characterization of Barbaloin Gel for the Safe and Effective Treatment of Psoriasis. Journal of Drug Delivery and Therapeutics. 2020; 10(5):188-97.
- Sondhi S, Singh N, Jindal S. Natural Remedies used in the Treatment of Psoriasis: A short Review. Asian Journal of Pharmaceutical Research. 2021;11(1):43-5.
- Sharma S, Sharma R, Goyal K, Jindal S. Potential of herbal treatment of Psoriasis: A Laconic Review. Asian Journal of Research in Pharmaceutical Sciences. 2021;11(1):51-7.
- Sondhi S, Singh N, Goyal K, Jindal S. Development of Topical Herbal Gel of Berberine Hydrochloride for the Treatment of Psoriasis. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021;13(1):12-8.
- Sharma A, Anghore D, Awasthi R, Kosey S, Jindal S, Gupta N, Raj D, Sood R. A Review on Current Carbon Nanomaterials and Other Nanoparticles Technology and Their Applications in Biomedicine. World Journal Pharmacy and Pharmaceutical Science. 2015;4(12):1088-113.
- Jindal S, Awasthi R, Singare D, Kulkarni GT. Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells. Herba Polonica. 2021; 67(1): 35-45.
- A Laconic Review on Chalcones: Synthesis, Antimicrobial and Antioxidant activities
Authors
1 1Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
2 Department of Pharmacology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India., IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
4 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, H.P., India, IN
5 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, H.P., India., IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 21-28Abstract
Chalcones and their derivatives have been an area of great interest for several researchers in recent years. Several number of research publications have been published and chalcones continue to show promising effect for novel drug investigations. Chalcone is an advantaged moiety with therapeutic importance as it comprises of receptive ketoethylenic moiety – CO–CH=CH– having a place with flavonoids. Chalcones (1, 3-Diphenyl-prop-2-en-1-one) consists of a three carbon α, β-unsaturated carbonyl system and two or more aromatic rings and acts as precursors for the biosynthesis of flavonoids in plants. The presence of a highly reactive α, β-unsaturated carbonyl system in chalcone and its derivatives is the justification for its pharmacological potencies. However, synthesis in laboratory of broad range of chalcones has also been reported. Chalcones show a wide range of pharmacological impacts like anthelmintic, antileishmanial, antifungal, antimalarial, antioxidant, antiviral, antibacterial, antiulcer, antimycobacterial, insecticidal, antigout, antihistaminic, antiprotozoal, insecticidal, anticancer, antidiabetic, anti-inflammatory, analgesic etc. Chalcones can be synthesized through Claisen–Schmidt's condensation, Heck's reaction, Aldol condensation reaction, Suzuki's reaction, from cinnamic acid, Sonogashira Isomerization Coupling reaction, Microwave assisted synthesis etc. The purpose of the present review is to centralize the various and widely employed methods of synthesis of chalcone and their various derivatives and their antimicrobial and antioxidant activities.Keywords
Chalcones, Antimicrobial activity, Antioxidant activity, Claisen–Schmidt condensation, Microwave assisted synthesis.References
- Kostanecki SV. Tambor. Synthesis, Characterization and Biological Evaluation of Some Novel Chalcone Derivatives Containing Imidazo [1, 2-a] Pyridine. Moiety J Chem. Ber. 1899; 32: 1921-9.
- Elias DW, Beazely MA, Kandepu NM. Bioactivities of chalcones. Current Medicinal Chemistry. 1999;6(12):1125.
- Go ML, Wu X, Liu XL. Chalcones: an update on cytotoxic and chemoprotective properties. Current Medicinal Chemistry. 2005; 12(4): 483-99.
- Di Carlo G, Mascolo N, Izzo AA, Capasso F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sciences. 1999; 65(4): 337-53.
- Monga V, Goyal K, Steindel M, Malhotra M, Rajani DP, Rajani SD. Synthesis and evaluation of new chalcones, derived pyrazoline and cyclohexenone derivatives as potent antimicrobial, antitubercular and antileishmanial agents. Medicinal Chemistry Research. 2014; 23(4): 2019-32.
- Singh P, Anand A, Kumar V. Recent developments in biological activities of chalcones: a mini review. European Journal of Medicinal Chemistry. 2014; 85:758-77.
- Singh PP, Jayalakshmi B, Kumar NS. Synthesis, Characterization and Antimicrobial Evaluation of Some New Chalcones. Asian Journal of Research in Chemistry. 2013;6(12):1133-6.
- Dawane BS, Shaikh BM, Khandare NT, Mandawad GG, Chobe SS, Konda SG. Synthesis of Some Novel Substituted Pyrazole Based Chalcones and Their In-Vitro Antimicrobial Activity. Asian Journal of Research in Chemistry. 2010;3(1):90-3.
- Beena KP, Rajesh P, Nathiya S. Synthesis of some novel substituted isoxazoline based chalcones and their in-vitro antimicrobial activity. Asian Journal of Research in Chemistry. 2010;3(4):1080-2.
- Parveen P, Usha P, Naik VV, Sultana SS, Ramya MG. Synthesis of Chalcones and Evaluation of Their Anti-Microbial Activity. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014;6(1):26.
- Rao GE, Rahaman SA, Rani AP, Rao CM. Synthesis, Characterization and Antimicrobial Activity of Novel Chalcones from 1-[4-(1H-imidazol-1-yl) Phenyl] Ethanone. Asian Journal of Research in Chemistry. 2013;6(7):7.
- Sharma VP, Kumar R. Synthesis, Characterization and Antimicrobial Screening of Some Novel Chromonyl Chalcones. Asian Journal of Research in Chemistry. 2014;7(7):649-52.
- Lunkad AS, Kothawade SN, Jadhav DV, Chaudhari PS, Bornare SP. Synthesis and Antimicrobial Activity of Some New Chalcones Containing Benzofuran and Benzofuran Schiff Bases. Research Journal of Pharmacy and Technology. 2015;8(3):276.
- Kumar P, Kumar A, D'Souza S. Synthesis and Antimicrobial Evaluation of Different Substituted Phenylpropenone Pyrrolyl Chalcones. Research Journal of Pharmacy and Technology. 2017;10(5):1426-8.
- Baviskar B, Patel S, Baviskar B, Khadabadi SS, Shiradkar M. Design and synthesis of some novel chalcones as potent antimicrobial agent. Asian Journal of Research in Chemistry. 2008;(2):67-9.
- Polo E, Ibarra-Arellano N, Prent-Peñaloza L, Morales-Bayuelo A, Henao J, Galdámez A, Gutiérrez M. Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. Bioorganic Chemistry. 2019; 90:103034.
- Pola S, Banoth KK, Sankaranarayanan M, Ummani R, Garlapati A. Design, synthesis, in silico studies, and evaluation of novel chalcones and their pyrazoline derivatives for antibacterial and antitubercular activities. Medicinal Chemistry Research. 2020;(10):1819-35.
- de Mello MV, de Azevedo Abrahim-Vieira B, Domingos TF, de Jesus JB, de Sousa AC, Rodrigues CR, de Souza AM. A comprehensive review of chalcone derivatives as antileishmanial agents. European Journal of Medicinal Chemistry. 2018;150:920- 9.
- Maguire CJ, Carlson GJ, Ford JW, Strecker TE, Hamel E, Trawick ML, Pinney KG. Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues. Medicinal Chemistry Communications. 2019;10(8):1445-56.
- Sharma A, Anghore D, Awasthi R, Kosey S, Jindal S, Gupta N, Raj D, Sood R. A Review on Current Carbon Nanomaterials and Other Nanoparticles Technology and Their Applications in Biomedicine. World Journal of Pharmacy and Pharmaceutical Science. 2015;4(12):1088-113.
- Shukla P, Satyanarayana M, Verma PC, Tiwari J, Dwivedi AP, Srivastava R, Rehuja N, Srivastava SP, Gautam S, Tamrakar AK, Dwivedi AK. Chalcone-based aryloxypropanolamine as a potential antidiabetic and antidyslipidaemic agent. Current Science. 2017:1675-89.
- Mahapatra DK, Shivhare RS, Kumar P. Murrayanine-chalcone transformed into novel pyrimidine compounds demonstrated promising anti-inflammatory activity. Asian Journal of Pharmaceutical Research. 2018;8(1):6-10.
- Lin YM, Zhou Y, Flavin MT, Zhou LM, Nie W, Chen FC. Chalcones and flavonoids as anti-tuberculosis agents. Bioorganic and Medicinal Chemistry. 2002;10(8):2795-802.
- Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. The Journal of Nutritional Biochemistry. 2002;13(10):572-84.
- Kakati D, Sarma JC. Microwave assisted solvent free synthesis of 1, 3-diphenylpropenones. Chemistry Central Journal. 2011;5(1):1- 5.and nonprenylated chalcones and flavanones in vitro. Journal of Agricultural and Food Chemistry. 2000;48(9):3876-84.
- Ni L, Meng CQ, Sikorski JA. Recent advances in therapeutic chalcones. Expert Opinion on Therapeutic Patents. 2004; 14(12): 1669-91.
- Downs LE, Wolfe DM, Schreiner PR. Organic Base‐Mediated Condensation of Pyridinecarboxaldehydes to Azachalcones. Advanced Synthesis and Catalysis. 2005;347(2‐3):235-8.
- Prakash O, Kumar A, Sadana A, Prakash R, Singh SP, Claramunt RM, Sanz D, Alkorta I, Elguero J. Study of the reaction of chalcone analogs of dehydroacetic acid and o-aminothiophenol: synthesis and structure of 1, 5-benzothiazepines and 1, 4-benzothiazines. Tetrahedron. 2005;61(27):6642-51.
- Prasad YR, Rao AL, Prasoona L, Murali K, Kumar PR. Synthesis and antidepressant activity of some 1, 3, 5-triphenyl-2-pyrazolines and 3-(2″-hydroxy naphthalen-1″-yl)-1,5-diphenyl-2-pyrazolines. Bioorganic and Medicinal Chemistry Letters. 2005;15(22):5030-4.
- Gupta S, Maurya P, Upadhyay A, Kushwaha P, Krishna S, Siddiqi MI, Sashidhara KV, Banerjee D. Synthesis and bio-evaluation of indole-chalcone based benzopyrans as promising antiligase and antiproliferative agents. European Journal of Medicinal Chemistry. 2018;143:1981-96.
- Goyal K, Kaur R, Goyal A, Awasthi R. Chalcones: A review on synthesis and pharmacological activities. Journal of Applied Pharmaceutical Science. 2021;1 (Supp 1):001–014.
- Gaonkar SL, Vignesh UN. Synthesis and pharmacological properties of chalcones: a review. Research on Chemical Intermediates. 2017;43(11):6043-77.
- Smith HE, Paulson MC. The Preparation of Chalcones from Hydroxy and Methoxy Aldehydes and Ketones1. Journal of the American Chemical Society. 1954;76(17):4486-7.
- Palaniandavar M, Natarajan C. Cobalt (II), nickel (II) and copper (II) complexes of some 2'-hydroxychalcones. Australian Journal of Chemistry. 1980;33(4):737-45.
- Morrison RT, Boyd RN. Organic Chemistry, 6th edn., Pearson Education Publishers. 2004; 971–990, 997–1020.
- Eddarir S, Cotelle N, Bakkour Y, Rolando C. An efficient synthesis of chalcones based on the Suzuki reaction. Tetrahedron letters. 2003;44(28):5359-63.
- Bianco A, Cavarischia C, Farina A, Guiso M, Marra C. A new synthesis of flavonoids via Heck reaction. Tetrahedron letters. 2003;44(51):9107-9.
- Braun RU, Ansorge M, Müller TJ. Coupling–Isomerization synthesis of chalcones. Chemistry–A European Journal. 2006;12(35):9081-94.
- Müller TJ, Ansorge M, Aktah D. An Unexpected Coupling–Isomerization Sequence as an Entry to Novel Three‐Component‐Pyrazoline Syntheses. Angewandte Chemie International Edition. 2000;39(7):1253-6.
- Bora U, Saikia A, Boruah RC. A new protocol for synthesis of alpha, beta-unsaturated ketones using zirconium tetrachloride under microwave irradiation. Indian Journal of Chemistry Section B. 2005;44(12):2523.
- Ramakrishnan VT, Kagan J. Photochemical conversion of phenyl epoxycinnamate to flavonoids and the synthesis of 2'-hydroxyepoxychalcone. The Journal of Organic Chemistry. 1970;35(9):2898-900.
- Baba T, Kizuka H, Handa H, Ono Y. Reaction of ketones or aldehydes with 1-alkynes over solid-base catalysts. Applied Catalysis A: General. 2000; 194:203-11.
- Burmaoglu S, Algul O, Anıl DA, Gobek A, Duran GG, Ersan RH, Duran N. Synthesis and anti-proliferative activity of fluoro-substituted chalcones. Bioorganic and Medicinal Chemistry Letters. 2016;26(13):3172-6.
- Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, da Silva Bolzani V, Graminha MA. Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds. Bioorganic and Medicinal Chemistry Letters. 2015;25(16):3342-5.
- Cheng MS, Li RS, Kenyon G. A solid phase synthesis of chalcones by Claisen-Schmidt condensations. Chinese Chemical Letters. 2000;11(10):851-4.
- Watanabe KI, Imazawa A. Aldol condensations catalyzed by Co (II) complexes of pyridine-containing copolymers. Bulletin of the Chemical Society of Japan. 1982;55(10):3208-11.
- Rammohan A, Reddy JS, Sravya G, Rao CN, Zyryanov GV. Chalcone synthesis, properties and medicinal applications: a review. Environmental Chemistry Letters. 2020;18(2):433-58.
- Ananthnag GS, Adhikari A, Balakrishna MS. Iron-catalyzed aerobic oxidative aromatization of 1, 3, 5-trisubstituted pyrazolines. Catalysis Communications. 2014;43:240-3.
- Zhang Z, Wang Y, Wang M, Lu J, Zhang C, Li L, Jiang J, Wang F. The cascade synthesis of α, β-unsaturated ketones via oxidative C–C coupling of ketones and primary alcohols over a ceria catalyst. Catalysis Science and Technology. 2016;6(6):1693-700.
- Jagdale AR, Sudalai A. p-Toluenesulfonic acid mediated hydroarylation of cinnamic acids with anisoles and phenols under metal and solvent-free conditions. Tetrahedron Letters. 2007;48(28):4895-8.
- Schramm OG, Mueller TJ. Microwave‐Accelerated Coupling‐Isomerization Reaction (MACIR)–A General Coupling‐Isomerization Synthesis of 1, 3‐Diarylprop‐2‐en‐1‐ones. Advanced Synthesis and Catalysis. 2006;348(18):2565-70.
- Mistry RN, Desai KR. Microwave Studies on Synthesis of Some New Heterocyclic Chalcone and Pyrimidine-2-thione Derivatives and Their Antibacterial Activity. Asian Journal of Chemistry. 2004;16(1):201.
- Gall EL, Texier-Boullet F, Hamelin J. Simple access to α, β unsaturated ketones by acid-catalyzed solvent-free reactions. Synthetic Communications. 1999;29(20):3651-7.
- Baviskar BA, Baviskar B, Shiradkar MR, Deokate UA, Khadabadi SS. Synthesis and Antimicrobial Activity of Some Novel Benzimidazolyl Chalcones. E-Journal of Chemistry. 2009; 6(1): 196-200.
- Prasad YR, Kumar PP, Kumar PR, Rao AS. Synthesis and antimicrobial activity of some new chalcones of 2-acetyl pyridine. E-Journal of Chemistry. 2008;5(1):144-8.
- Rathore MM, Rajput PR, Parhate VV. Synthesis and antimicrobial activity of some chalcones and flavones. International Journal of Chemical and Physical Sciences. 2015; 4:473-77.
- Rajput SS, Sayyed RA. Synthesis and Evaluation of Antimicrobial Activity of Some Novel Chalcones of 2, 6-Dichloro-4-Trifluoro Methyl Aniline. Heterocyclic Letters. 2017;7(2):333-9.
- Özdemir A, Altıntop MD, Sever B, Gençer HK, Kapkaç HA, Atlı Ö, Baysal M. A new series of pyrrole-based chalcones: synthesis and evaluation of antimicrobial activity, cytotoxicity, and genotoxicity. Molecules. 2017;22(12):2112.
- Lal K, Yadav P, Kumar A, Kumar A, Paul AK. Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1, 2, 3-triazole hybrids. Bioorganic Chemistry. 2018; 77:236-44.
- Kalaiselvi E, Arunadevi R, Sashikala S. Synthesis, Characterization and Antimicrobial Activity of a Chalcone Derivative. Journal of Science and Technology. 2020;5(4):335-43.
- Radwan MA, Alshubramy MA, Abdel-Motaal M, Hemdan BA, El-Kady DS. Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives. Bioorganic Chemistry. 2020; 96:103516.
- da Silva PT, da Cunha Xavier J, Freitas TS, Oliveira MM, Coutinho HD, Leal AL, Barreto HM, Bandeira PN, Nogueira CE, Sena Jr DM, Almeida-Neto FW. Synthesis, spectroscopic characterization and antibacterial evaluation by chalcones derived of acetophenone isolated from Croton anisodontus Müll. Arg. Journal of Molecular Structure. 2021; 1226:129403.
- Kumar CS, Loh WS, Ooi CW, Quah CK, Fun HK. Structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential. Molecules. 2013;18(10):11996-2011.
- Murti Y, Goswam A, Mishra P. Synthesis and antioxidant activity of some chalcones and flavanoids. International Journal of PharmTech Research. 2013; 5:811-8.
- Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR. Antioxidant and prooxidant actions of prenylated
- Lahsasni SA, Al Korbi FH, Aljaber NA. Synthesis, characterization and evaluation of antioxidant activities of some novel chalcones analogues. Chemistry Central Journal. 2014;8(1):1-10.
- Aly MR, Fodah HH, Saleh SY. Antiobesity, antioxidant and cytotoxicity activities of newly synthesized chalcone derivatives and their metal complexes. European Journal of Medicinal Chemistry. 2014;76:517-30.
- Sivakumar PM, Prabhakar PK, Doble M. Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones. Medicinal Chemistry Research. 2011;20(4):482-92.
- Qian YP, Shang YJ, Teng QF, Chang J, Fan GJ, Wei X, Li RR, Li HP, Yao XJ, Dai F, Zhou B. Hydroxychalcones as potent antioxidants: structure–activity relationship analysis and mechanism considerations. Food chemistry. 2011;126(1):241-8.
- Akhtar MS, Rehman AU, Arshad H, Malik A, Fatima M, Tabassum T, Raza AR, Bukhsh M, Murtaza MA, Mehmood MH, Sultan A. In Vitro Antioxidant Activities and the Therapeutic Potential of Some Newly Synthesized Chalcones Against 4-Acetaminophenol Induced Hepatotoxicity in Rats. Dose-Response. 2021;19(1):1559325821996955.
- Application of Nanocarrier in Drug development with special Emphasis on Liposomes: A Review
Authors
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 4 (2022), Pagination: 320-328Abstract
Liposomes are the nano-scale bilayer structure of phospholipid used as a carrier for a Large Variety of drugs. Both lipophilic and hydrophilic drugs can encapsulate into the liposome and delivered to the body. The purpose behind the preparation of liposomes is to reduce the side effects associated with systemic delivery of drugs as well as it also helps in the protection of biodegradable drugs and molecules such as protein and peptides from body enzymes and fluids. Other than these advantages liposome also have high skin permeation due to structural similarities with the stratum corneum and therefore can be used for the topical delivery of drugs. The various types of liposomes and their application in their marketed products are discussed below in the article.Keywords
Liposome, Gene Therapy, Theranostic ApplicationsReferences
- Gomez-Hens A, Fernández-Romero JM. The role of liposomes in analytical processes. TrAC Trends Anal Chem. 2005;24(1):9–19.
- Has C, Sunthar P. A comprehensive review on recent preparation techniques of liposomes. J Liposome Res. 2020;30(4):336–65.
- Manconi M, Caddeo C, Sinico C, Valenti D, Mostallino MC, Biggio G, et al. Ex vivo skin delivery of diclofenac by transcutol containing liposomes and suggested mechanism of vesicle–skin interaction. Eur J Pharm Biopharm. 2011;78(1):27–35.
- Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci. 2009;71(4):349.
- Akhtar N. Vesicles: a recently developed novel carrier for enhanced topical drug delivery. Curr Drug Deliv. 2014;11(1):87–97.
- Jindal S, Awasthi R, Singare D, Kulkarni GT. Preparation and in vitro evaluation of Tacrolimus loaded liposomal vesicles by two methods: A comparative study. J Res Pharm. 2021;25(1):34–41.
- Chowdhury A, Kunjiappan S, Panneerselvam T, Somasundaram B, Bhattacharjee C. Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases. Int nano Lett. 2017;7(2):91–122.
- Siddiqi KS, Husen A, Sohrab SS, Yassin MO. Recent status of nanomaterial fabrication and their potential applications in neurological disease management. Nanoscale Res Lett. 2018;13(1):1–17.
- Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic nanoparticles and their targeted delivery applications. Molecules. 2020;25(9):2193.
- Greish K, Fang J, Inutsuka T, Nagamitsu A, Maeda H. Macromolecular therapeutics. Clin Pharmacokinet. 2003;42(13):1089–105.
- Iyer AK, Khaled G, Fang J, Maeda H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov Today. 2006;11(17–18):812–8.
- Nakamura H, Jun F, Maeda H. Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls. Expert Opin Drug Deliv. 2015;12(1):53–64.
- Çağdaş M, Sezer AD, Bucak S. Liposomes as potential drug carrier systems for drug delivery. Appl Nanotechnol drug Deliv. 2014;1:1–50.
- Ranade V V. Drug delivery systems. 1. Site‐specific drug delivery using liposomes as carriers. J Clin Pharmacol. 1989;29(8):685–94.
- Choudhury H, Gorain B, Pandey M, Chatterjee LA, Sengupta P, Das A, et al. Recent update on nanoemulgel as topical drug delivery system. J Pharm Sci. 2017;106(7):1736–51.
- Rahimpour Y, Hamishehkar H. Liposomes in cosmeceutics. Expert Opin Drug Deliv. 2012;9(4):443–55.
- Kaur IP, Kakkar S. Topical delivery of antifungal agents. Expert Opin Drug Deliv. 2010;7(11):1303–27.
- Li W, Joshi MD, Singhania S, Ramsey KH, Murthy AK. Peptide vaccine: progress and challenges. Vaccines. 2014;2(3):515–36.
- Gregory AE, Williamson D, Titball R. Vaccine delivery using nanoparticles. Front Cell Infect Microbiol. 2013;3:13.
- Tandrup Schmidt S, Foged C, Smith Korsholm K, Rades T, Christensen D. Liposome-based adjuvants for subunit vaccines: formulation strategies for subunit antigens and immunostimulators. Pharmaceutics. 2016;8(1):7.
- Khalaj‐Hedayati A, Chua CLL, Smooker P, Lee KW. Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement. Influenza Other Respi Viruses. 2020;14(1):92–101.
- Li J, Wang X, Zhang T, Wang C, Huang Z, Luo X, et al. A review on phospholipids and their main applications in drug delivery systems. Asian J Pharm Sci. 2015;10(2):81–98.
- Singh RP, Gangadharappa H V, Mruthunjaya K. Phospholipids: Unique carriers for drug delivery systems. J Drug Deliv Sci Technol. 2017;39:166–79.
- Paltauf F, Hermetter A. Phospholipids—Natural, semisynthetic, synthetic. In: Phospholipids. Springer; 1990. p. 1–12.
- Ahmed KS, Hussein SA, Ali AH, Korma SA, Lipeng Q, Jinghua C. Liposome: Composition, characterisation, preparation, and recent innovation in clinical applications. J Drug Target. 2019;27(7):742–61.
- Silvius JR. Role of cholesterol in lipid raft formation: lessons from lipid model systems. Biochim Biophys Acta (BBA)-Biomembranes. 2003;1610(2):174–83.
- Harayama T, Riezman H. Understanding the diversity of membrane lipid composition. Nat Rev Mol cell Biol. 2018;19(5):281–96.
- Zhukovsky MA, Filograna A, Luini A, Corda D, Valente C. Phosphatidic acid in membrane rearrangements. FEBS Lett. 2019;593(17):2428–51.
- Iscaro A, Howard NF, Muthana M. Nanoparticles: properties and applications in cancer immunotherapy. Curr Pharm Des. 2019;25(17):1962–79.
- P Samy R, Gopalakrishnakone P, G Stiles B, S Girish K, N Swamy S, Hemshekhar M, et al. Snake venom phospholipases A2: a novel tool against bacterial diseases. Curr Med Chem. 2012;19(36):6150–62.
- Jindal S, Awasthi R, Singhare D, Kulkarni GT. Topical delivery of Tacrolimus using liposome containing gel: An emerging and synergistic approach in management of psoriasis. Med Hypotheses. 2020;142:109838.
- Medina OP, Zhu Y, Kairemo K. Targeted liposomal drug delivery in cancer. Curr Pharm Des. 2004;10(24):2981–9.
- Panahi Y, Farshbaf M, Mohammadhosseini M, Mirahadi M, Khalilov R, Saghfi S, et al. Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications. Artif cells, nanomedicine, Biotechnol. 2017;45(4):788–99.
- Daraee H, Etemadi A, Kouhi M, Alimirzalu S, Akbarzadeh A. Application of liposomes in medicine and drug delivery. Artif cells, nanomedicine, Biotechnol. 2016;44(1):381–91.
- Jindal S, Kumar A, Goyal K, Awasthi R, Kulkarni GT. Lipid Nanocarriers for Dermal Delivery of Lutein. In: Nanomedicine for Bioactives. Springer; 2020. p. 341–66.
- Mura S, Nicolas J, Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater. 2013;12(11):991–1003.
- Huang Z, Li X, Zhang T, Song Y, She Z, Li J, et al. Progress involving new techniques for liposome preparation. asian J Pharm Sci. 2014;9(4):176–82.
- Mozafari MR. Liposomes: an overview of manufacturing techniques. Cell Mol Biol Lett. 2005;10(4):711.
- Paternostre MT, Roux M, Rigaud JL. Mechanisms of membrane protein insertion into liposomes during reconstitution procedures involving the use of detergents. 1. Solubilization of large unilamellar liposomes (prepared by reverse-phase evaporation) by triton X-100, octyl glucoside, and sodium. Biochemistry. 1988;27(8):2668–77.
- Edwards K, Johnsson M, Karlsson G, Silvander M. Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes. Biophys J. 1997;73(1):258–66.
- Kumar S, Kaur N, Mithu VS. Amphiphilic ionic liquid induced fusion of phospholipid liposomes. Phys Chem Chem Phys. 2020;22(43):25255–63.
- Zhang H. Thin-film hydration followed by extrusion method for liposome preparation. In: Liposomes. Springer; 2017. p. 17–22.
- Fernández-García R, Lalatsa A, Statts L, Bolás-Fernández F, Ballesteros MP, Serrano DR. Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale. Int J Pharm. 2020;573:118817.
- Varona S, Martin A, Cocero MJ. Liposomal incorporation of lavandin essential oil by a thin-film hydration method and by particles from gas-saturated solutions. Ind Eng Chem Res. 2011;50(4):2088–97.
- Marsden HR, Gabrielli L, Kros A. Rapid preparation of polymersomes by a water addition/solvent evaporation method. Polym Chem. 2010;1(9):1512–8.
- Zhang X, Coleman AC, Katsonis N, Browne WR, Van Wees BJ, Feringa BL. Dispersion of graphene in ethanol using a simple solvent exchange method. Chem Commun. 2010;46(40):7539–41.
- Kim SW, Kim T, Kim YS, Choi HS, Lim HJ, Yang SJ, et al. Surface modifications for the effective dispersion of carbon nanotubes in solvents and polymers. Carbon N Y. 2012;50(1):3–33.
- Ming-Jie LI, ZHANG H-Y, Xiao-Zhe LIU, Chun-Yan CUI, Zhi-Hong SHI. Progress of extraction solvent dispersion strategies for dispersive liquid-liquid microextraction. Chinese J Anal Chem. 2015;43(8):1231–40.
- Chen J, Brooks III CL, Khandogin J. Recent advances in implicit solvent-based methods for biomolecular simulations. Curr Opin Struct Biol. 2008;18(2):140–8.
- Szoka F, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci. 1978;75(9):4194–8.
- Mertins O, Sebben M, Pohlmann AR, da Silveira NP. Production of soybean phosphatidylcholine–chitosan nanovesicles by reverse phase evaporation: a step by step study. Chem Phys Lipids. 2005;138(1–2):29–37.
- Taylor KMG, Taylor G, Kellaway IW, Stevens J. Drug entrapment and release from multilamellar and reverse-phase evaporation liposomes. Int J Pharm. 1990;58(1):49–55.
- Trucillo P, Campardelli R, Reverchon E. Liposomes: From bangham to supercritical fluids. Processes. 2020;8(9):1022.
- Jung J, Perrut M. Particle design using supercritical fluids: literature and patent survey. J Supercrit Fluids. 2001;20(3):179–219.
- Naik S, Patel D, Surti N, Misra A. Preparation of PEGylated liposomes of docetaxel using supercritical fluid technology. J Supercrit Fluids. 2010;54(1):110–9.
- Xia F, Hu D, Jin H, Zhao Y, Liang J. Preparation of lutein proliposomes by supercritical anti-solvent technique. Food Hydrocoll. 2012;26(2):456–63.
- Booysen E. Characterization of a novel antibiotic isolated from Xenorhabdus khoisanae and encapsulation of vancomycin in nanoparticles. Stellenbosch: Stellenbosch University; 2018.
- Lesoin L, Crampon C, Boutin O, Badens E. Preparation of liposomes using the supercritical anti-solvent (SAS) process and comparison with a conventional method. J Supercrit Fluids. 2011;57(2):162–74.
- Kompella UB, Koushik K. Preparation of drug delivery systems using supercritical fluid technology. Crit Rev Ther Drug Carr Syst. 2001;18(2).
- Amoabediny G, Haghiralsadat F, Naderinezhad S, Helder MN, Akhoundi Kharanaghi E, Mohammadnejad Arough J, et al. Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review. Int J Polym Mater Polym Biomater. 2018;67(6):383–400.
- van Swaay D, DeMello A. Microfluidic methods for forming liposomes. Lab Chip. 2013;13(5):752–67.
- Yu B, Lee RJ, Lee LJ. Microfluidic methods for production of liposomes. Methods Enzymol. 2009;465:129–41.
- Amrani S. Microfluidic platform for the fabrication and loading of nanoscale liposomes by 2D hydrodynamic flow focusing. McGill University (Canada); 2018.
- Cheung C. Preparation of Multifunctional Nanoparticles Using Microfluidics. Queen’s University Belfast; 2020.
- Shum HC, Thiele J, Kim S-H. Microfluidic fabrication of vesicles. Adv Transp Phenom 2011. 2014;1–28.
- Hu PC, Li S, Malmstadt N. Microfluidic fabrication of asymmetric giant lipid vesicles. ACS Appl Mater Interfaces. 2011;3(5):1434–40.
- Vayssieres L, Keis K, Hagfeldt A, Lindquist S-E. Three-dimensional array of highly oriented crystalline ZnO microtubes. Chem Mater. 2001;13(12):4395–8.
- Ding X, Zeng D, Zhang S, Xie C. C-doped WO3 microtubes assembled by nanoparticles with ultrahigh sensitivity to toluene at low operating temperature. Sensors Actuators B Chem. 2011;155(1):86–92.
- Li Q, Wang X, Ma S, Zhang Y, Han X. Electroformation of giant unilamellar vesicles in saline solution. Colloids Surfaces B Biointerfaces. 2016;147:368–75.
- Stein H, Spindler S, Bonakdar N, Wang C, Sandoghdar V. Production of isolated giant unilamellar vesicles under high salt concentrations. Front Physiol. 2017;8:63.
- Kuribayashi K, Tresset G, Coquet P, Fujita H, Takeuchi S. Electroformation of giant liposomes in microfluidic channels. Meas Sci Technol. 2006;17(12):3121.
- Kanha N, Regenstein JM, Surawang S, Pitchakarn P, Laokuldilok T. Properties and kinetics of the in vitro release of anthocyanin-rich microcapsules produced through spray and freeze-drying complex coacervated double emulsions. Food Chem. 2021;340:127950.
- Kim TH, Park TG. Critical effect of freezing/freeze-drying on sustained release of FITC-dextran encapsulated within PLGA microspheres. Int J Pharm. 2004;271(1–2):207–14.
- Supramaniam P, Ces O, Salehi-Reyhani A. Microfluidics for artificial life: techniques for bottom-up synthetic biology. Micromachines. 2019;10(5):299.
- Monteiro N, Martins A, Reis RL, Neves NM. Liposomes in tissue engineering and regenerative medicine. J R Soc Interface. 2014;11(101):20140459.
- Xue J, Wu T, Dai Y, Xia Y. Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chem Rev. 2019;119(8):5298–415.
- Mohanraj VJ, Chen Y. Nanoparticles-a review. Trop J Pharm Res. 2006;5(1):561–73.
- Jadhav SM, Morey P, Karpe M, Kadam V. Novel vesicular system: an overview. J Appl Pharm Sci. 2012;2(1):193–202.
- Narvekar M, Xue HY, Eoh JY, Wong HL. Nanocarrier for poorly water-soluble anticancer drugs—barriers of translation and solutions. Aaps Pharmscitech. 2014;15(4):822–33.
- Alam A, Farooq U, Singh R, Dubey VP, Kumar S, Kumari R, et al. Chemotherapy treatment and strategy schemes: A review. Open Access J Toxicol. 2018;2(5):555600.
- Pérez-Herrero E, Fernández-Medarde A. Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm. 2015;93:52–79.
- Overchuk M, Zheng G. Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics. Biomaterials. 2018;156:217–37.
- Lila ASA, Ishida T. Liposomal delivery systems: design optimization and current applications. Biol Pharm Bull. 2017;40(1):1–10.
- Sharma G, Anabousi S, Ehrhardt C, Ravi Kumar MN V. Liposomes as targeted drug delivery systems in the treatment of breast cancer. J Drug Target. 2006;14(5):301–10.
- Singh N, Sondhi S, Sharma S, Singh D, Koundal V, Goyal K, et al. Treatment of Skin Cancer by Topical Drug Delivery of Nanoparticles: A Review. Res J Pharm Technol. 2021;14(10):5589–98.
- Tamura A, Nagasaki Y. Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles. Nanomedicine. 2010;5(7):1089–102.
- Mohammadinejad R, Dehshahri A, Madamsetty VS, Zahmatkeshan M, Tavakol S, Makvandi P, et al. In vivo gene delivery mediated by non-viral vectors for cancer therapy. J Control Release. 2020;325:249–75.
- Jindal S, Awasthi R, Singare D, Kulkarni GT. POTENTIAL OF HERBAL NANOCARRIER FORMULATION FOR THE TREATMENT OF PSORIASIS. Int J Pharm Life Sci. 2019;10(6).
- Goldberg M, Langer R, Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J Biomater Sci Polym Ed. 2007;18(3):241–68.
- Zhou J, Rossi JJ. Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides. 2011;21(1):1–10.
- Saad M, Garbuzenko OB, Minko T. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. 2008;
- Frezard F. Liposomes: from biophysics to the design of peptide vaccines. Brazilian J Med Biol Res. 1999;32(2).
- Nam G, Choi Y, Kim GB, Kim S, Kim SA, Kim I. Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy. Adv Mater. 2020;32(51):2002440.
- Madni A, Sarfraz M, Rehman M, Ahmad M, Akhtar N, Ahmad S, et al. Liposomal drug delivery: a versatile platform for challenging clinical applications. J Pharm Pharm Sci. 2014;17(3):401–26.
- García A, De Sanctis JB. An overview of adjuvant formulations and delivery systems. Apmis. 2014;122(4):257–67.
- Du Y-F, Chen M, Xu J-R, Luo Q, Lu W-L. Preparation and Characterization of DNA Liposomes Vaccine. Liposome-Based Drug Deliv Syst. 2021;259–75.
- Sharma A, Anghore D, Awasthi R, Kosey S, Jindal S, Gupta N, et al. A review on current carbon nanomaterials and other nanoparticles technology and their applications in biomedicine. World J Pharm Pharm Sci. 2015;4(12):1088–113.
- Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomedicine. 2015;10:975.
- Gowda GAN, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D. Metabolomics-based methods for early disease diagnostics. Expert Rev Mol Diagn. 2008;8(5):617–33.
- Papanicolaou GN, Traut HF. Diagnosis of uterine cancer by the vaginal smear. New York. 1943;46.
- Mulder WJM, Strijkers GJ, Griffioen AW, van Bloois L, Molema G, Storm G, et al. A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets. Bioconjug Chem. 2004;15(4):799–806.
- Mukundan Jr S. Ghaghada KB, Badea CT, Kao CY, Hedlund LW, Provenzale JM, Johnson GA, Chen E, Bellamkonda RV, Annapragada A. A liposomal nanoscale contrast agent for preclinical CT in mice. AJR Am J Roentgenol. 2006;186(2):300–7.
- Costabile RA, Choyke PL, Frank JA, Girton ME, Diggs R, Billups KL, et al. Dynamic enhanced magnetic resonance imaging of testicular perfusion in the rat. J Urol. 1993;149(5):1195–7.
- Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: an application update. Int J Cosmet Sci. 2008;30(1):19–33.
- Budai L, Kaszás N, Gróf P, Lenti K, Maghami K, Antal I, et al. Liposomes for topical use: A physico-chemical comparison of vesicles prepared from egg or soy lecithin. Sci Pharm. 2013;81(4):1151–66.
- Al-Jamal W, Kostarelos K. Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc Chem Res. 2011;44(10):1094–104.
- Svenson S. Theranostics: are we there yet? Mol Pharm. 2013;10(3):848–56.
- Mukherjee A, Paul M, Mukherjee S. Recent progress in the theranostics application of nanomedicine in lung cancer. Cancers (Basel). 2019;11(5):597.
- Yin W, Kimbrough CW, Gomez-Gutierrez JG, Burns CT, Chuong P, Grizzle WE, et al. Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography. J Nanobiotechnology. 2015;13(1):1–11.
- Gurka MK, Pender D, Chuong P, Fouts BL, Sobelov A, McNally MW, et al. Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography. J Control release. 2016;231:60–7.
- Wallace TL, Larson JL, Bazemore SA, Wilson CW, Cossum PA. The nonclinical safety evaluation of the anticancer drug ATRAGEN®(Liposomal all-trans-retinoic acid). Int J Toxicol. 2000;19(1):33–42.
- Brogden RN, Goa KL, Coukell AJ. Amphotericin-B colloidal dispersion. A review of its use against systemic fungal infections and visceral leishmaniasis. Drugs. 1998 Sep;56(3):365–83.
- Sharma M, Joshi J, Chouhan NK, Talati MN, Vaidya S, Kumar A. Liposome-A Comprehensive Approach for Researchers. In: Molecular Pharmacology. IntechOpen; 2020.
- Chhikara BS, Parang K. Development of cytarabine prodrugs and delivery systems for leukemia treatment. Expert Opin Drug Deliv. 2010;7(12):1399–414.
- Porche DJ. Liposomal doxorubicin (Doxil). J Assoc Nurses AIDS Care. 1996;7(2):55–9.
- Wang R, Billone PS, Mullett WM. Nanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trials. J Nanomater. 2013;2013.
- Peravali R, Brock R, Bright E, Mills P, Petty D, Alberts J. Enhancing the Enhanced Recovery Program in Colorectal Surgery-use of extended-release epidural morphine (DepoDur®). Ann Coloproctol. 2014;30(4):186.
- Estradiol-topical--Novavax: Estrasorb. Drugs R D. 2003;4(1):49–51.
- Lea AP, Balfour JA. Virosomal hepatitis A vaccine (strain RG-SB). BioDrugs. 1997;7(3):232–48.
- Xiong Y-Q, Kupferwasser LI, Zack PM, Bayer AS. Comparative efficacies of liposomal amikacin (MiKasome) plus oxacillin versus conventional amikacin plus oxacillin in experimental endocarditis induced by Staphylococcus aureus: microbiological and echocardiographic analyses. Antimicrob Agents Chemother. 1999;43(7):1737–42.
- Dhandapani NV, Thapa A, Sandip G, Shrestha A, Shrestha N, Bhattarai RS. Liposomes as novel drug delivery system: A comprehensive review. 2013;
- Kalepu S, Nekkanti V. Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharm Sin B. 2015;5(5):442–53.
- Johnson EM, Ojwang JO, Szekely A, Wallace TL, Warnock DW. Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations. Antimicrob Agents Chemother. 1998;42(6):1412–6.
- Passero Jr FC, Grapsa D, Syrigos KN, Saif MW. The safety and efficacy of Onivyde (irinotecan liposome injection) for the treatment of metastatic pancreatic cancer following gemcitabine-based therapy. Expert Rev Anticancer Ther. 2016;16(7):697–703.
- Application of Berberine on Skin Diseases: A Review
Authors
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist - Kangra (H.P.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 14, No 4 (2022), Pagination: 304-308Abstract
The plants containing berberine have been used for the treatment of skin diseases, inflammatory disorders, and reducing fevers, wound healing, digestive and respiratory diseases and in treatment of tumors. By taking the specific properties of the berberine, this review describes the method mentioned in the literature regarding the berberine extraction. Furthermore, many experimental and clinical studies suggest that berberine has several pharmacological activities such as antioxidative, cardioprotective, nephroprotective, and hepatoprotective effect. This review summarizes the information about botanical occurrence, traditional uses and pharmacological effects of berberine and berberine containing plants.Keywords
Berberine, Skin Diseases, Psoriasis.References
- Chen Y Y, Chang F R, Wu Y C. Isoquinoline alkaloids and lignans from Rollinia mucosa. Journal of Natural Products. 1996; 59: 904-906.
- Singh A, Duggal S, Kaur N, Singh J. Berberine: Alkaloid with wide spectrum of pharmacological activities. J. Nat. Prod.2010; 3: 64–75.
- Dev S. A Selection of Prime Ayurvedic Plants Drugs ancientModern Concordance. New Delhi: Anamaya Publishers; 2006.
- Kirtikar K R, Basu B D. Indian Medicinal Plants. Allahabad : CSIR Publications. 1998;1.
- Kataoka M, Tokuyama E, Miyananga Y, Uchida T. The taste sensory evaluation of medicinal plants and Chinese medicines. Int. J. Pharm. 2008; 36–44.
- Fabricant D S, Famsworth N R. The value of plants used in traditional medicine for drug discovery. Journal of Environmental Health Perspectives. 2005; 69.
- Rosjanga P, Gritsanapan W. Variation of berberine content in the Coscinium fenestratum Stem in Thailand Market. Mahidol University Journal of Pharmaceutical Sciences. 2005;32: 66-70
- Andola H C, Gaira K S, Rawal M S, Bhatt I D, Purohit V K. Variations of berberine content of Berberis asiatica. Western Himalaya Chem Biodiversity. (2010a) ; 7:415-420.
- Andola H C, Rawal R S, Rawat M S M, Bhatti I D, Purohit V K. Variations of berberine contents in Berberis pseudumbellata. A High Value Medicinal shrub of West Himalaya. India Medicinal plants Journal of Phytomedicines and related industries. (2010b); 2: 111-115.
- Tome F, Colombo M L. Distribution of alkaloids in Chelidonium majus and factor affecting their accumulation. Phytochemistry. 1995; 37-39.
- Chandra P, Purohit A N. Berberine contents and alkaloid profile of Berberis species from different altitudes. Biochemistry systems Ecology. 1980; 379-380.
- Mikage M, Mouri C. Pharmacognostical studies of Berberis plants from Nepal (1) altitudinal, interspecific and partial variations of berberine content in the barks. Pharmaceutics; 249-254.
- Marek R, Seckarova P, Hulova D, Marek J, Dostal J, Sklenar V. Palmatine and Berberine isolation artifacts. Journal Of Natural Products. 2003; 66: 481-486.
- Grycova L, Dostal J, Marek R. Quaternary protoberberine alkaloids. Phytochemistry. 2007; 68: 150-175.
- Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakrobarty S. The Interplay: Oxidative stress, pro-oxidants and oxidants. Biomedical Research International. 2014.
- Thirupurasundari C J, Padmini R, Devaraj S N. Effect of berberine on antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane- induced colon cancer in rats. Journal of Chemistry Biological Int. 2009; 177: 190-195.
- Zeng X. Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studies by HPLC. Biomedical Chromatogram. 1999; 13: 442-444.
- Chi L, Peng L, Pan N, Hu X, ZhangY, The anti-atherogenic effects of berberine of foam cell formation mediated through upregulation of sirutin I. International Journal of Molecular Medicines. 2014; 34: 1087-1093.
- Cicero A, Ertek S. Berberine: Metabolic and cardiovascular effects in preclinical and clinical trials. Journal of Nutraceuticals Diet Supplement. 2009; 1: 1-10.
- Chang T Y, Li B L, Chang C C, Urano Y. Acyl-coenzyme A: Cholesterol acyltransferases. Journal of Physiology- endocrinology and metabolism. 2009; E1-E9.
- Wang Y, Yi X, Ghanam K, Zhang S, Zhao T, Zhu X. Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption. Mrtabolism 2014; 63: 1167-1177.
- Yin J, Gao Z, Liu, D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Journal of Physiology- endocrinology and metabolism. 2008; 148-156.
- Xia X, Yan J, Shen Y, Tang K, Yin J, Zhang Y. Berberine improves glucose metabolism in diabetic rat by ingibition of hepatic gluconeogenesis. 2011.
- Chen Y, Wang Y, Lin L, Zhang Y, Sun C, Lopez A. Berberine improves glucose homeostasis in streptozotocin- induced diabetic rats in association with multiple factors of insulin resistance. ISRN Endorinol. 2011; 1-8.
- Dai P, Wang J, Lin L, Zhang Y, Wang Z. Renoprotective effects of berberine as adjuvant therapy for hypertensive patients with TypeII Diabetes mellitus: Evaluation via biochemical markers and color Doppler ultrasonography. Journal of experimental and therapeutic Medicine. 2015; 10: 869-876.
- Zhao X, Zhang J, Tong N, Chen Y, Luo Y. Protective effects of berberine on Doxorubicin- induced hepatotoxicity in mice. Journal of Biological and Pharmaceutical Bulletin. 2012; 35: 796-800.
- Domitrovic R, Jakovac H, Blagojevic G. Hepatoprotective activity of berberine mediated by inhibition of TNF-α, COX-2 expression in CCl4-intoxicated mice. Toxicology. 2011; 33-43.
- Kim S, Chung J H. Berberine prevents UV-induced MMP-I and reduction of type-I procollagen expression in human dermal fibroblasts. Phytomedicine.2008; 15: 749-753.
- Yahki K, Kiso A, Zhou Y Y. Abstracts: The effects of Coptis japonica root extract and its key component, berberine on human subcutaneous adipocytes. International Journal of Cosmetic Sciences. 2010; 32: 392-395.
- Derosa G, Maffioli P, Cicero A F. Berberine on Metabolic and Cardiovascular risk factors: An analysis from preclinical evidences to clinical trials. Expert Opinion Biomolecular Theory. 2012; 12: 1113-1124.
- Fouladi R F. 2012. Aqueous extract of dried fruit of berberis vulgaris L. in acne vulgaris, a clinical trial. Journal of Dietary Supplement. 2012; 9: 253-261.
- Johnson M, Rafikhah N. Berberis vulgaris juice and acne vulgaris: a placebo-controlled study. Asian Journal of Clinical Nutrition. 2014; 6: 47-52.
- Gupta DK, Aqil M, Sultana Y. Tailoring of berberine loaded transniosomes for the management of skin cancer in mice. Journal of Drug Delivery Science and Technology. 2020; 60: 1-13.
- Torky AS, Maha MA, Abdallah AY. Novel skin penetrating berberine oleate complex capitalizing on hydrophobic ion pairing approach. International Journal of Pharmaceutics. 2018; 76-86.
- Vanti G, Wang M, Billia AR. Hydroxypropyl methylcellulose hydrogel of berberine chlorideloaded escinosomes: Dermal absorption and biocompatibility. International Journal of Biological Macromolecule. 2020; 1-29.
- Niu J, Yuan M, Chen C, Wang L, Gan Y. Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention. International Journal of Nanomedicine.2020; 1-19.
- Lin H, Lim L, Choi Y. Development and in-vitro evaluation of coloaded berberine chloride and evodiamine ethosomes for treatment of melanoma. International Journal of Pharmaceutics. 2020; 1-7.
- Vanti G, Bani D, Salvatici CM, Bergonzi MC, Billia AR. Development and Percutaneous Permeation Study of Escinosomes, Escin-Based Nanovesicles Loaded with Berberine Chloride. Pharmaceutics. 2019; 1-22.
- Gull A, Ahmed S, Ahmed FS, Chandra. Hydrogel thickened microemulsion; a local cargo for the co- delivery of cinnamaldehyde and berberine to treat acne vulgaris. Journal of Drug Delivery Science and Technology. 2020; 58: 1-10
- Amato G, Grimaudo MA, Lorenzo CA, Carbone C, Musumeci T. Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing. Pharmaceutics. 2020; 1-11.
- Mayangsari F, Surini S, Iswandana R. Development of transfersomal emulgel to enhance the permeation of berberine chloride for transdermal delivery. Journal of Applied Pharmaceutical Science. 2022; 12(02): 48-55.
- Awate P S, Pimple T P, Pananchery JF, Jain A S. Formulation and evaluation of berberine hcl as niosomal drug delivery system. Asian Journal of Pharmaceutical Research. 2020; 10(3).
- Rahamat U, Kumar P M, Gella S. Psoriasis: A comprehensive Review. Asian J. of Res.in Pharma. Sciences. 2019; 9(1): 29-38.
- Mahajan T, Singh N, Goyal K, Jindal S, Pandit V, Ashawat MS. Recent updates on Psoriasis: A Review. Asian Journal of Pharmaceutical research. 2022; 12(1): 3-76.
- Singh N, Sondhi S, Jindal S, Pandit V, Ashawat MS. Treatment and Management for patients with mild to severe Psoriasis: A Review. Asian Journal of Pharmaceutical Research. 2020; 10(4):286-292.
- Sondhi S, Singh N, Jindal S. Natural Remedies used in treatment of Psoriasis: A Short review. Asian Journal of Pharmaceutical Research. 2021; 11(1): 43-45.
- Sharma S, Sharma R, Goyal K, Jindal S. Potential of herbal treatment of Psoriasis: A Laconic Review. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(1): 51-57.
- Sondhi S, Singh N, Goyal K, Jindal S. Development of Topical Herbal gel of Berberine Hydrochloride for the treatment of Psoriasis. 2021; 13(1): 12-18.
- Verma D, Samal P K. Evaluation of Synergistic analgesic Activity of Berberine and Asiatic Acid in Mice. Research Journal of Pharmacy and Technology. 2020; 13(12): 6081-6085.
- Singh N, Goyal K, Sondhi S, Jindal S. Traditional and medicinal use of Barbaloin: Potential for the Management of Various Disease. 2020; 8(3): 21-30.
- Singh N, Goyal K, Sondhi S, Jindal S. Development and characterization of Barbaloin Gel for the safe and effective treatment of Psoriasis. Journal of Drug Delivery and Therapeutics. 2020; 10(5): 188-197.
- Fusidic Acid: A Therapeutic Review
Authors
1 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India., IN
2 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India, IN
3 1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India, IN
4 Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India., IN
5 Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawalaji, Distt. Kangra (H.P.) India ., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 5 (2022), Pagination: 372 - 380Abstract
Fusidic acid (FA), derived from the fungus Fusidium coccineum, is an antimicrobial agent that inhibits bacterial protein synthesis by preventing EF-G translocation. This review will provide information regarding the properties of FA, as well as studies on its clinical efficacy in skin and soft-tissue infections (SSTIs). FA has been used for treatment of infection caused by gram- positive microorganism. FA cream or ointment are clinically effective and shown minimum adverse reaction when used in SSTIs two or three times regularly. The analytical methods which describe the presence of FA in biological samples and pharmaceutical formulations are reviewed in this article. High-performance liquid chromatography has been widely used analytical method in the analysis of FA, as it can reduce the cost as well as time of analysis. This review also includes the information regarding the randomised trials which investigates the clinical efficacy of fusidic acid in dermatology in comparative trials that were discovered.Keywords
High-performance liquid chromatography, Gram- positive microorganism.References
- Kim S, Covington A, Pamer EG. The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens. Immunol Rev. 2017;279(1):90–105.
- Fisher RA, Gollan B, Helaine S. Persistent bacterial infections and persister cells. Nat Rev Microbiol. 2017;15(8):453–64.
- Russell AD. Biocide use and antibiotic resistance: the relevance of laboratory findings to clinical and environmental situations. Lancet Infect Dis. 2003;3(12):794–803.
- Kumar U, Narang R, Nayak SK, Singh SK, Gupta V. Benzimidazole: Structure Activity Relationship and Mechanism of Action as Antimicrobial Agent. Res J Pharm Technol. 2017;10(7):2400–14.
- Fischbach MA, Walsh CT. Antibiotics for emerging pathogens. Science (80). 2009;325(5944):1089–93.
- Gerarden TD, Newell RG, Stavins RN. Assessing the energy-efficiency gap.J Econ Lit. 2017;55(4):1486–525.
- Lippi G, Chance JJ, Church S, Dazzi P, Fontana R, Giavarina D, et al. Preanalytical quality improvement: from dream to reality. Clin Chem Lab Med. 2011;49(7):1113–26.
- Sonawane L V, Poul BN, Usnale S V, Waghmare P V, Surwase LH. Bioanalytical method validation and its pharmaceutical application-a review. Pharm Anal Acta. 2014;5(288):2.
- Curbete MM, Salgado HRN. A critical review of the properties of fusidic acid and analytical methods for its determination. Crit Rev Anal Chem. 2016;46(4):352–60.
- Barbosa-Filho JM, Nascimento Júnior FA do, Tomaz AC de A, AthaydeFilho PF de, Silva MS da, Cunha E V, et al. Natural products with antileprotic activity. Rev Bras Farmacogn. 2007;17(1):141–8.
- Zhao M, Gödecke T, Gunn J, Duan J-A, Che C-T. Protostane and fusidane triterpenes: a mini-review. Molecules. 2013;18(4):4054–80.
- Werner AH, Russell AD. Mupirocin, fusidic acid and bacitracin: activity, action and clinical uses of three topical antibiotics. Vet Dermatol. 1999;10(3):225–40.
- Fujii T, Nakada M. Stereoselective construction of the ABC-ring system of fusidane triterpenes via intermolecular/transannular Michael reaction cascade. Tetrahedron Lett. 2014;55(9):1597–601.
- Li C, Li XZ, Graham N, Gao NY. The aqueous degradation of bisphenol A and steroid estrogens by ferrate. Water Res. 2008;42(1–2):109–20.
- Wudy SA, Schuler G, Sánchez-Guijo A, Hartmann MF. The art of measuring steroids: principles and practice of current hormonal steroid analysis. J Steroid Biochem Mol Biol. 2018;179:88–103.
- Buetow DE, Levedahl BH. Responses of microorganisms to sterols and steroids. Annu Rev Microbiol. 1964;18(1):167–94.
- Gehrig KA, Warshaw EM. Allergic contact dermatitis to topical antibiotics: epidemiology, responsible allergens, and management. J Am Acad Dermatol. 2008;58(1):1–21.
- Frimodt-Møller N. 74 Fusidic Acid (Fusidate Sodium). USE Antibiot. 2010;945.
- Karauzum H, Venkatasubramaniam A, Adhikari RP, Kort T, Holtsberg FW, Mukherjee I, et al. IBT-V02: a multicomponent toxoid vaccine protects against primary and secondary skin infections caused by Staphylococcus aureus. Front Immunol. 2021;12:475.
- Singer AJ, Talan DA. Management of skin abscesses in the era of methicillin-resistant Staphylococcus aureus. N Engl J Med. 2014;370(11):1039–47.
- Revathi K. Contact Allergies in Patients with Leg Ulcers. PSG Institute of Medical Sciences and Research, Coimbatore; 2015.
- Larsen FS, Simonsen L, Melgaard A, Wendicke K, Henriksen AS. An efficient new formulation of fusidic acid and betamethasone 17-valerate (Fucicort® Lipid cream) for treatment of clinically infected atopic dermatitis. Acta Derm Venereol. 2007;87(1):62–8.
- Girolomoni G, Mattina R, Manfredini S, Vertuani S, Fabrizi G. Fusidic acid betamethasone lipid cream. Int J Clin Pract. 2016;70:4–13.
- Bryskier A. Fusidic acid. Antimicrob Agents Antibacterials Antifung. 2005;631–41.
- Ragab AE, Ibrahim A-RS, Léon F. 3-O-Formyl-27-Hydroxyfusidic Acid: A New Metabolite of Fusidic Acid by Cunninghamella echinulata. Rec Nat Prod. 2020;14(4):296.
- Gaohua L, Miao X, Dou L. Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity. Expert Opin Drug Metab Toxicol. 2021;17(9):1103–24.
- Shriner RL, Hermann CKF, Morrill TC, Curtin DY, Fuson RC. The systematic identification of organic compounds. John Wiley & Sons; 2003.
- Morgan PW, Kwolek SL. Low temperature solution polycondensation of piperazine polyamides. J Polym Sci Part A Gen Pap. 1964;2(1):181–208.
- Zembower TR, Noskin GA, Postelnick MJ, Nguyen C, Peterson LR. The utility of aminoglycosides in an era of emerging drug resistance. Int J Antimicrob Agents. 1998;10(2):95–105.
- Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, et al. Levonadifloxacin, a novel broad-spectrum anti-MRSA benzoquinolizine quinolone agent: review of current evidence. Drug Des Devel Ther. 2019;13:4351.
- Dziwornu GA, Kamunya S, Ntsabo T, Chibale K. Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin. Medchemcomm. 2019;10(6):961–9.
- Peske F, Savelsbergh A, Katunin VI, Rodnina M V, Wintermeyer W. Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA–mRNA translocation. J Mol Biol.
- ;343(5):1183–94.
- Musmade PB, Tumkur A, Trilok M, Bairy KL. Fusidic acid–Topical antimicrobial in the management of Staphylococcus aureus. Int J Pharm Pharm Sci. 2013;5:381–90.
- Ward A, Campoli-Richards DM. Mupirocin. Drugs. 1986;32(5):425–44.
- Cé R, Pacheco BZ, Ciocheta TM, Barbosa FS, de CS Alves A, Dallemole DR, et al. Antibacterial activity against Gram-positive bacteria using fusidic acid-loaded lipid-core nanocapsules. React Funct Polym. 2021;162:104876.
- Mohamed MF, Abdelkhalek A, Seleem MN. Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus. Sci Rep. 2016;6(1):1–14.
- Ki V, Rotstein C. Bacterial skin and soft tissue infections in adults: a review of their epidemiology, pathogenesis, diagnosis, treatment and site of care.Can J Infect Dis Med Microbiol. 2008;19(2):173–84.
- Seltzer E, Dorr MB, Goldstein BP, Perry M, Dowell JA, Henkel T, et al. Once-weekly dalbavancin versus standard-of-care antimicrobial regimens for treatment of skin and soft-tissue infections. Clin Infect Dis.
- ;37(10):1298–303.
- Turnidge J, Collignon P. Resistance to fusidic acid. Int J Antimicrob Agents. 1999;12:S35–44.
- Thakur K, Sharma G, Singh B, Chhibber S, Katare OP. Nano-engineered lipid-polymer hybrid nanoparticles of fusidic acid: an investigative study on dermatokinetics profile and MRSA-infected burn wound model. Drug Deliv Transl Res. 2019;9(4):748–63.
- Cassir N, Rolain J-M, Brouqui P. A new strategy to fight antimicrobial resistance: the revival of old antibiotics. Front Microbiol. 2014;5:551.
- Garner JS, Committee HICPA. Guideline for isolation precautions in hospitals. Infect Control Hosp Epidemiol. 1996;17(1):54–80.
- Maisch T, Szeimies R-M, Jori G, Abels C. Antibacterial photodynamic therapy in dermatology. Photochem Photobiol Sci. 2004;3(10):907–17.
- Nishijima S, Namura S, Kawai S, Akamatsu H, Asada Y, Kawabata S. Sensitivity of Staphylococcus aureus and Streptococcus pyogenes isolated from skin infections in 1992 to antimicrobial agents. J Dermatol.1994;21(4):233–8.
- Chiller K, Selkin BA, Murakawa GJ. Skin microflora and bacterial infections of the skin. In: Journal of Investigative Dermatology Symposium Proceedings. Elsevier; 2001. p. 170–4.
- Casillas-Vargas G, Ocasio-Malavé C, Medina S, Morales-Guzmán C, Del Valle RG, Carballeira NM, et al. Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents. Prog Lipid Res. 2021;82:101093.
- Savelsbergh A, Rodnina M V, Wintermeyer W. Distinct functions of elongation factor G in ribosome recycling and translocation. Rna.2009;15(5):772–80.
- Gupta A, Mir SS, Saqib U, Biswas S, Vaishya S, Srivastava K, et al. The effect of fusidic acid on Plasmodium falciparum elongation factor G (EF-G).Mol Biochem Parasitol. 2013;192(1–2):39–48.
- Shi X, Khade PK, Sanbonmatsu KY, Joseph S. Functional role of the sarcin–ricin loop of the 23S rRNA in the elongation cycle of protein synthesis. J Mol Biol. 2012;419(3–4):125–38.
- Baca OG, Rohrbach MS, Bodley JW. Studies on translocation. 22. Equilibrium measurements of the interactions of guanine nucleotides with Escherichia coli elongation factor G and the ribosome. Biochemistry.1976;15(21):4570–4.
- Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, Clark BFC, et al. Crystal structure of the ternary complex of Phe-tRNAPhe, EFTu, and a GTP analog. Science (80- ). 1995;270(5241):1464–72.
- Kinzy TG, Woolford Jr JL. Increased expression of Saccharomyces cerevisiae translation elongation factor 1 alpha bypasses the lethality of a TEF5 null allele encoding elongation factor 1 beta. Genetics.
- ;141(2):481–9.
- Song JM. Genetic and molecular studies of genes that affect translational fidelity in Saccharomyces cerevisiae. University of Illinois at Chicago; 1987.
- Sharma S, Sharma R, Goyal K, Jindal S. Potential of herbal treatment of Psoriasis: A Laconic Review. Asian J Res Pharm Sci. 2021;11(1):51–7.
- Sondhi S, Singh N, Goyal K, Jindal S. Development of topical herbal gel of berberine hydrochloride for the treatment of psoriasis. Res J Pharm Dos Forms Technol. 2021;13(1):12–8.
- Sondhi S, Singh N, Jindal S. Natural Remedies used in the Treatment of Psoriasis: A short Review. Asian J Pharm Res. 2021;11(1):43–5.
- Mahajan T, Singh N, Goyal K, Jindal S, Pandit V, Ashawat MS. Recent Updates on Psoriasis: A Review Tejasavi Mahajan1, Navdeep Singh1, Kamya Goyal2, Shammy Jindal1*, Vinay Pandit1, MS Ashawat1 1Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog Jawalaji Dist-Kangra (HP) India. 2Department of Pharmaceutical Analysis and Quality Assurance, Laureate Institute of Pharmacy, Kathog Jawalaji Dist-Kangra (HP) India.* Corresponding Author E-mail: shammyjindal@ gmail. com. Asian J Pharm Res. 2022;12(1):76–83.
- Singh N, Sondhi S, Jindal S, Pandit V, Ashawat MS. Treatment and Management for patients with mild to severe Psoriasis: A Review. Asian J Pharm Res. 2020;10(4):286–92.
- Singh N, Goyal K, Sondhi S, Jindal S. Development and Characterization of Barbaloin Gel for the Safe and Effective Treatment of Psoriasis. J Drug Deliv Ther. 2020;10(5):188–97.
- Vani PB, Kumar PR. A Comparative Review on Conventional and Traditional medicine in the Treatment of Psoriasis. Res J Pharm Technol. 2020;13(11):5642–6.
- Yadav K, Singh D, Singh MR. Development and Characterization of Corticosteroid loaded Lipid carrier system for Psoriasis. Res J Pharm Technol. 2021;14(2):966–70.
- Thomas J, Parimalam K. Treating pediatric plaque psoriasis: challenges and solutions. Pediatr Heal Med Ther. 2016;7:25.
- Kulawik-Pióro A, Miastkowska M. Polymeric gels and their application in the treatment of psoriasis vulgaris: a review. Int J Mol Sci.2021;22(10):5124.
- Ramanunny AK, Wadhwa S, Singh SK, Sharma DS, Khursheed R, Awasthi A. Treatment strategies against psoriasis: principle, perspectives and practices. Curr Drug Deliv. 2020;17(1):52–73.
- Chen L, Zhou L, Wang C, Han Y, Lu Y, Liu J, et al. Tumor‐targeted drug and CpG delivery system for phototherapy and docetaxel‐enhanced immunotherapy with polarization toward M1‐type macrophages on triple negative breast cancers. Adv Mater. 2019;31(52):1904997.
- Porro GB, Parente F. Side effects of anti-ulcer prostaglandins: an overview of the worldwide clinical experience. Scand J Gastroenterol. 1989;24(sup164):224–31.
- Christiansen K. Fusidic acid adverse drug reactions. Int J Antimicrob Agents. 1999;12:S3–9.
- Enjalbert F, Rapior S, Nouguier-Soulé J, Guillon S, Amouroux N, Cabot C. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol. 2002;40(6):715–57.
- Biswas M, Owen K, Jones MK. Hypocalcaemia during fusidic acid therapy. J R Soc Med. 2002;95(2):91–3.
- Lee WM, Larson AM, Stravitz RT. AASLD position paper: the management of acute liver failure: update 2011. Hepatology. 2011;55(3):965–7.
- Høvding G. Acute bacterial conjunctivitis. Acta Ophthalmol. 2008;86(1):5– 17.
- Long BH. 2. Fusidic acid in skin and soft-tissue infections. Acta Derm Venereol. 2008;
- Principi N, Argentiero A, Neglia C, Gramegna A, Esposito S. New antibiotics for the treatment of acute bacterial skin and soft tissue infections in pediatrics. Pharmaceuticals. 2020;13(11):333.
- Njoroge M, Kaur G, Espinoza-Moraga M, Wasuna A, Dziwornu GA, Seldon R, et al. Semisynthetic antimycobacterial C-3 Silicate and C-3/C-21 ester derivatives of fusidic acid: Pharmacological evaluation and stability studies in liver microsomes, rat plasma, and mycobacterium tuberculosis culture. ACS Infect Dis. 2019;5(9):1634–44.
- Ballard BE. Biopharmaceutical considerations in subcutaneous and intramuscular drug administration. J Pharm Sci. 1968;57(3):357–78.
- Goossens A, Gonçalo M. Contact allergy to topical drugs. Contact Dermatitis. 2020;1–37.
- Griffin JP, D’Arcy PF. A manual of adverse drug interactions. Elsevier; 1997.
- Roberts CJC. Clinical Pharmacological Considerations. In: Gastrointestinal Disease. Springer; 1983. p. 155–68.
- Petitjean O, Nicolas P, Tod M, Padoin C, Jacolot A. Drug Interactions during Anti‐Infective Treatments. Antimicrob agents antibacterials Antifung. 2005;1320–52.
- Pryor JB, Lockridge J, Olyaei AJ. The Principles of Drug Dosing in Peritoneal Dialysis. In: Applied Peritoneal Dialysis. Springer; 2021. p. 349– 74.
- Turner P, Volans G, Wiseman H. Approved Names. In: Drugs Handbook 1992–93. Springer; 1992. p. 1–100.
- Neuman M. Useful and Harmful Interactions of. 1985; 83. Frohlich S, Ryan T, Fagan C. Statin therapy associated with fatal rhabdomyolysis. J Intensive Care Soc. 2011;12(1):40–2.
- Jain KK. Drug-induced myopathies. In: Drug-induced Neurological Disorders. Springer; 2021. p. 493–509.
- Singh B. Major concerns on antibiotic resistance and antibiotic-induced complications–paradigm shift to nanaoscale and secondary metabolites from edible plants for rapid killing of bacteria as an imperative.
- Shafran SD, Tyring SK, Ashton R, Decroix J, Forszpaniak C, Wade A, et al. Once, twice, or three times daily famciclovir compared with aciclovir for the oral treatment of herpes zoster in immunocompetent adults: a randomized, multicenter, double-blind clinical trial. J Clin Virol. 2004;29(4):248–53.
- Spelman D. Fusidic acid in skin and soft tissue infections. Int J Antimicrob Agents. 1999;12:S59–66.
- Török E, Somogyi T, Rutkai K, Iglesias L, Bielsa I. Fusidic acid suspension twice daily: a new treatment schedule for skin and soft tissue infection in children, with improved tolerability. J Dermatolog Treat. 2004;15(3):158– 63.
- Kyhse-Andersen J, Schmidt C, Nordin G, Andersson B, Nilsson-Ehle P, Lindström V, et al. Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem. 1994;40(10):1921–6.
- Read TRH, Jensen JS, Fairley CK, Grant M, Danielewski JA, Su J, et al. Use of pristinamycin for macrolide-resistant Mycoplasma genitalium infection. Emerg Infect Dis. 2018;24(2):328.
- Raz R, Naber KG, Raizenberg C, Rohana Y, Unamba-Oparah I, Korfman G, et al. Ciprofloxacin 250 mg twice daily versus ofloxacin 200 mg twice daily in the treatment of complicated urinary tract infections in women. Eur J Clin Microbiol Infect Dis. 2000;19(5):327–31.
- Geerdes-Fenge HF, Goetschi B, Rau M, Borner K, Koeppe P, Wettich K, et al. Comparative pharmacokinetics of dirithromycin and erythromycin in normal volunteers with special regard to accumulation in polymorphonuclear leukocytes and in saliva. Eur J Clin Pharmacol. 1997;53(2):127–33.
- Bradshaw CS, Twin J, Bissessor M, Read TRH, Jensen JJ, Fairley CK, et al. 006.1 The efficacy of pristinamycin for mycoplasma genitalium–an increasing multidrug resistant pathogen. BMJ Publishing Group Ltd; 2015.
- Segreti J, Nelson JA, Trenholme GM. Prolonged suppressive antibiotic therapy for infected orthopedic prostheses. Clin Infect Dis. 1998;27(4):711– 3.
- Doudoulakakis A, Spiliopoulou I, Spyridis N, Giormezis N, Kopsidas J,Militsopoulou M, et al. Emergence of a Staphylococcus aureus clone resistant to mupirocin and fusidic acid carrying exotoxin genes and causing mainly skin infections. J Clin Microbiol. 2017;55(8):2529–37.
- Gibson JR. Trimethoprin-polymyxin B ophthalmic solution in the treatment of presumptive bacterial conjunctivitis—A multicentre trial of its efficacy versus neomycin–polymyxin B-gramicidin and chloramphenicol ophthalmic solutions. J Antimicrob Chemother. 1983;11(3):217–21.
- Hamann K, Thorn P. Systemic or Local Treatment of Erythrasma? A comparison between Erythromycin Tablets and FucidinR Cream in General Practice. Scand J Prim Health Care. 1991;9(1):35–9.
- Cole C, Gazewood JD. Diagnosis and treatment of impetigo. Am Fam Physician. 2007;75(6):859–64.
- Qin X, Song M, Ma H, Yin C, Zhong Y, Zhang L, et al. Low‐temperature bleaching of cotton fabric with a binuclear manganese complex of 1, 4, 7‐ trimethyl‐1, 4, 7‐triazacyclononane as catalyst for hydrogen peroxide. Color Technol. 2012;128(5):410–5.
- Bigliardi PL, Alsagoff SAL, El-Kafrawi HY, Pyon J-K, Wa CTC, Villa MA. Povidone iodine in wound healing: A review of current concepts and practices. Int J Surg. 2017;44:260–8.
- Meaney-Delman D, Bartlett LA, Gravett MG, Jamieson DJ. Oral and intramuscular treatment options for early postpartum endometritis in lowresource settings: a systematic review. Obstet Gynecol. 2015;125(4):789– 800.
- Heydari R, Mousavi M. Simultaneous determination of saccharine, caffeine, salicylic acid and benzoic acid in different matrixes by salt and air-assisted homogeneous liquid-liquid extraction and high-performance liquid chromatography. J Chil Chem Soc. 2016;61(3):3090–4.
- Lodha R, Randev S, Kabra SK. Oral antibiotics for community–acquired pneumonia with chest-indrawing in children aged below five years: A Systematic Review. Indian Pediatr. 2016;53(6):489–95.
- Ma Y, Zhang N, Wu S, Huang H, Cao Y. Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical isolates from a hospital in Shanghai, China. Front Med. 2016;10(4):517–21.
- Morley PAR, Munot LD. A comparison of sodium fusidate ointment and mupirocin ointment in superficial skin sepsis. Curr Med Res Opin.1988;11(2):142–8.
- Golan Y. Current treatment options for acute skin and skin-structure infections. Clin Infect Dis. 2019;68(Supplement_3):S206–12.
- Stulberg DL, Penrod MA, Blatny RA. Common bacterial skin infections. Am Fam Physician. 2002;66(1):119.
- Denton M, O’Connell B, Bernard P, Jarlier V, Williams Z, Henriksen AS. The EPISA study: antimicrobial susceptibility of Staphylococcus aureus causing primary or secondary skin and soft tissue infections in the
- community in France, the UK and Ireland. J Antimicrob Chemother. 2008;61(3):586–8.
- Kakar N, Kumar V, Mehta G, Sharma RC, Koranne R V. Clinico‐bacteriological study of pyodermas in children. J Dermatol. 1999;26(5):288–93.
- Oranje AP, Chosidow O, Sacchidanand S, Todd G, Singh K, Scangarella N, et al. Topical retapamulin ointment, 1%, versus sodium fusidate ointment, 2%, for impetigo: a randomized, observer-blinded, noninferiority study.Dermatology. 2007;215(4):331–40.
- Wollenberg A, Christen‐Zäch S, Taieb A, Paul C, Thyssen JP, de Bruin‐ Weller M, et al. ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children. J Eur Acad Dermatology Venereol. 2020;34(12):2717–44.
- Sibbald RG, Orsted H, Schultz GS, Coutts P, Keast D. Preparing the wound bed 2003: focus on infection and inflammation. Ostomy Wound Manag. 2003;49(11):24–51.
- Chu AC. 4. Antibacterial/steroid combination therapy in infected eczema. Acta Derm Venereol. 2008;
- Poyner TF, Dass BK. Comparative efficacy and tolerability of fusidic acid/hydrocortisone cream (Fucidin® H cream) and miconazole/hydrocortisone cream (Daktacort® cream) in infected eczema. J
- Eur Acad Dermatology Venereol. 1996;7:S23–30.
- Rangegowda SM, Madhavrao D, Gunjahalli B, Shetty P, Ravikumar BC. Archives of Clinical & Experimental Dermatology. 2021;
- Hill VA, Wong E, Corbett MF, Menday AP. Comparative efficacy of betamethasone/clioquinol (Betnovate-C) cream and betamethasone/fusidicacid (Fucibet) cream in the treatment of infected hand eczema. J Dermatolog Treat. 1998;9(1):15–9.
- Bratovčić A, Odobašić A, Ćatić S. The advantages of the use of ionselective potentiometry in relation to UV/VIS spectroscopy. Agric Conspec Sci. 2009;74(3):139–42.
- Saleh GA, Askal HF, Darwish IA, El-Shorbagi A-NA. Spectroscopic analytical study for the charge-transfer complexation of certain cephalosporins with chloranilic acid. Anal Sci. 2003;19(2):281–7.
- Nakra S, Green RJ, Anderson SL. Thermal decomposition of JP-10 studied by micro-flowtube pyrolysis-mass spectrometry. Combust Flame.2006;144(4):662–74.
- Basner R, Schmidt M, Denisov E, Becker K, Deutsch H. Absolute total and partial cross sections for the electron impact ionization of tetrafluorosilane (SiF 4). J Chem Phys. 2001;114(3):1170–7.
- Al-Shaalan NH. Atomic absorption spectrometric determination of fusidic acid in bulk powder and in pharmaceutical dosage form. J Chem Pharm Res. 2010;2:135–43.
- Moradi M, Kashanaki R, Borhani S, Bigdeli H, Abbasi N, Kazemzadeh A. Optimization of supramolecular solvent microextraction prior to graphite furnace atomic absorption spectrometry for total selenium determination in food and environmental samples. J Mol Liq. 2017;232:243–50.
- Pedraza A, Sicilia MD, Rubio S, Pérez-Bendito D. Assessment of the surfactant-dye binding degree method as an alternative to the methylenblue method for the determination of anionic surfactants in aqueous environmental samples. Anal Chim Acta. 2007;588(2):252–60.
- Costi EM, Sicilia MD, Rubio S, Pérez-Bendito D. Quantitation of fusidane antibiotics in pharmaceuticals using the surfactant–dye binding degree method. Anal Chim Acta. 2005;549(1–2):159–65.
- Pedraza A, Sicilia MD, Rubio S, Pérez-Bendito D. Surfactant–dye binding degree method for the determination of amphiphilic drugs. Anal Chim Acta. 2004;522(1):89–97.
- Costi EM, Sicilia MD, Rubio S, Pérez-Bendito D. Determination of cationic surfactants in pharmaceuticals based on competitive aggregation in ternary amphiphile mixtures. Anal Chim Acta. 2006;577(2):257–63.
- Khan H. Analytical Method Development in Pharmaceutical Research: Steps involved in HPLC Method Development. Asian J Pharm Res. 2017;7(3):203–7.
- Gahart BL, Nazareno AR. Gahart’s 2018 Intravenous Medications: A Handbook for Nurses and Health Professionals. Elsevier Health Sciences;2017.
- Al-Ghobashy MA, Mostafa MM, Abed HS, Fathalla FA, Salem MY. Correlation between dynamic light scattering and size exclusion high performance liquid chromatography for monitoring the effect of pH on
- stability of biopharmaceuticals. J Chromatogr B. 2017;1060:1–9.
- Lebiedzińska A, Marszałł ML, Kuta J, Szefer P. Reversed-phase highperformance liquid chromatography method with coulometric electrochemical and ultraviolet detection for the quantification of vitamins B1 (thiamine), B6 (pyridoxamine, pyridoxal and pyridoxine) and B12 in animal and plant foods. J Chromatogr A. 2007;1173(1–2):71–80.
- Szabó T, Tombácz E, Illés E, Dékány I. Enhanced acidity and pH-dependent surface charge characterization of successively oxidized graphite oxides. Carbon N Y. 2006;44(3):537–45.
- Agrawal S, Ashokraj Y, Bharatam P V, Pillai O, Panchagnula R. Solid-state characterization of rifampicin samples and its biopharmaceutic relevance. Eur J Pharm Sci. 2004;22(2–3):127–44.
- Gilchrist SE, Letchford K, Burt HM. The solid-state characterization of fusidic acid. Int J Pharm. 2012;422(1–2):245–53.
- Sarkar M, Perumal OP, Panchagnula R. Solid-state characterization of nevirapine. Indian J Pharm Sci. 2008;70(5):619.
- Manfio ML, Agarrayua DA, Machado JC, Schmidt CA. A fully validated microbiological assay to evaluate the potency of ceftriaxone sodium. Brazilian J Pharm Sci. 2013;49(4):753–62.
- Ramautar R, Somsen GW, de Jong GJ. CE‐MS for metabolomics: developments and applications in the period 2012–2014. Electrophoresis.2015;36(1):212–24.
- Pembrey RS, Marshall KC, Schneider RP. Cell surface analysis techniques: what do cell preparation protocols do to cell surface properties? Appl Environ Microbiol. 1999;65(7):2877–94.
- Thomas V, Yallapu MM, Sreedhar B, Bajpai SK. A versatile strategy to fabricate hydrogel–silver nanocomposites and investigation of their antimicrobial activity. J Colloid Interface Sci. 2007;315(1):389–95.
- Pauli GF. qNMR—a versatile concept for the validation of natural product reference compounds. Phytochem Anal an Int J Plant Chem Biochem Tech. 2001;12(1):28–42.
- Zuluaga AF, Agudelo M, Rodriguez CA, Vesga O. Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics. BMC Clin Pharmacol. 2009;9(1):1–11.