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Shadnia, Shahin
- Intravascular Haemolysis due to Glucose -6- Phosphate Dehydrogenase Deficiency in a Patient with Aluminum Phosphide Poisoning
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Authors
Fariba Farnaghi
1,
Hamid Owliaey
2,
Hossein Hassanian-Moghaddam
2,
Shahin Shadnia
2,
Nader Momtazmanesh
1,
Nasim Zamani
2,
Omid Mehrpour
3
Affiliations
1 Department of Pediatrics, Loghman-Hakim Hospital
2 Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR
3 Medical Toxicology and Drug Abuse Research Center (MTDRC), Pasdaran Avenue, Birjand University of Medical Sciences, Birjand, IN
1 Department of Pediatrics, Loghman-Hakim Hospital
2 Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR
3 Medical Toxicology and Drug Abuse Research Center (MTDRC), Pasdaran Avenue, Birjand University of Medical Sciences, Birjand, IN
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 7, No 2 (2013), Pagination: 79-81Abstract
Aluminum phosphide (AlP) poisoning and glucose?6?phosphate dehydrogenase (G6PD) deficiency are two common clinical problems in Iran. However, hemolysis associated with AlP poisoning is extremely rare. We report a 24-year-old G6PD deficient patient with AlP poisoning presenting with intravascular hemolysis.Keywords
G6PD Deficiency, Aluminum Phosphide, HemolysisReferences
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- Mehrpour O, Jafarzadeh M, Abdollahi M: A systematic review of aluminium phosphide poisoning. Arh Hig Rada Toksikol 2012, 63: 61–73
- Mehrpour O, Singh S: Rice tablet poisoning: a major concern in Iranian population. Hum Exp Toxicol 2010, 29:701–2. 4. Mehrpour O, Keyler D, Shadnia S: Comment on Aluminum and zinc phosphide poisoning. Clin Toxicol (Phila) 2009, 47:838–9.
- Mehrpour O, Alfred S, Shadnia S, Keyler DE, Soltaninejad K, Chalaki N, Sedaghat M Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor. Hum Exp Toxicol 2008, 27:591–5.
- Shadnia S, Mehrpour O, Abdollahi M: Unintentional poisoning by phosphine released from aluminum phosphide. Hum Exp Toxicol 2008, 27:87–9.
- Goldfrank LR, Flomenbaum NE, Lewin NA. Goldfrank’s Toxicologic Emergencies. 7th ed. McGraw –Hill, New York, 2002; 1560.
- Mehrpour O, Abdollahi M. Poison treatment centers in Iran.Hum Exp Toxicol. 2012;31(3): 303-304
- Glader, BE. Glucose-6-phosphate dehydrogenase deficiency and related disorders of hexose monophosphate shunt and glutathione metabolism. Wintrobe’s Clinical Hematology, 10th ed, Lee, GR, Foerster, J, Lukens, J, et al (Eds), Williams & Wilkins, Baltimore, pp. 1176-90.
- Tripathy V, Reddy BM. Present status of understanding on the G6PD deficiency and natural selection. J Postgrad Med. 2007;53(3): 193-202.
- Soltaninejad K, Nelson LS, Khodakarim N, Dadvar Z, Shadnia S. Unusual complication of aluminum phosphide poisoning: Development of hemolysis and methemoglobinemia and its successful treatment.Indian J Crit Care Med 2011;15 (2): 117-9.
- Srinivas R, Agarwal R, Jairam A, Sakhuja V. Intravascular haemolysis due to glucose-6- phosphate dehydrogenase deficiency in a patient with aluminium phosphide poisoning. Emerg Med J 2007;24 (1): 67-8.
- Khurana V, Gambhir IS, Kishore D. Microangiopathic hemolytic anemia following disseminated intravascular coagulation in aluminum phosphide poisoning. Indian J Med Sci 2009;63(6):257-9.
- Shadnia S, Soltaninejad K, Hassanian-Moghadam H, et al. Methemoglobinemia in aluminum phosphide poisoning. Hum Exp Toxicol. 2011;30(3):250-3.
- Aggarwal P, Handa R, Wig N, Biswas A, Saxena R, Wali JP. Intravascular hemolysis in aluminium phosphide poisoning. Am J Emerg Med 1999; 17 (5): 488-9.
- Evaluation of Histopathological Changes in Fatal Aluminum Phosphide Poisoning
Abstract Views :234 |
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Authors
Affiliations
1 Department of Forensic Medicine, Faculty of Medicine, Medical Sciences/University of Tehran, IR
2 Department of Forensic Pathology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
3 Department of Forensic Toxicology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
4 Loghman Hakim Poison Center, Faculty of Medicine, Medical Sciences/University of Shaheed Beheshti, Tehran, IR
5 Autopsy Service, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
1 Department of Forensic Medicine, Faculty of Medicine, Medical Sciences/University of Tehran, IR
2 Department of Forensic Pathology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
3 Department of Forensic Toxicology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
4 Loghman Hakim Poison Center, Faculty of Medicine, Medical Sciences/University of Shaheed Beheshti, Tehran, IR
5 Autopsy Service, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
Source
Indian Journal of Forensic Medicine & Toxicology, Vol 2, No 2 (2008), Pagination: 34-36Abstract
This study examines histopathological changes of human organs in cases with aluminum phosphide fatal poisoning. The cases with aluminum phosphide fatal poisoning in Tehran Legal Medicine Center over 12 month period starting in March 2006, were studied. Necropsy was performed for all cases and liver, lung, brain, kidney and spleen were collected from all cases and fixed in formaldehyde solution (37% formalin).Tissue specimens were taken from organs and processed by routine histological method. Then any histhopathological changes were recorded by pathologist. In gross examination, almost all the vital organs were found to be congested. In microscopic study, the most frequent histopathological findings in liver were central venous congestion, degeneration of hepatocytes and mononuclear infiltration. In lung, alveolar thickening, and dilated capillaries were detected. Findings in the brain tissue revealed degenerated Nissel granule in the cytoplasm and deeply stained degenerated eccentric nucleus in brain cortex. Changes in the kidney included glomerulus's and intraparanchymal congestion. These findings indicated that histopathological changes are common in aluminum phosphide fatal poisoning.Keywords
Aluminum Phosphide, Histopathology, Fatal Poisoning.References
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