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Vernekar, Saumya
- Phytochemical Investigation and Antimicrobial Activity of Inchnocarpus Frustescens Rhizome
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Authors
Affiliations
1 Department of Pharmacognosy, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda-Goa,, IN
2 Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda-Goa., IN
1 Department of Pharmacognosy, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda-Goa,, IN
2 Department of Pharmaceutical Chemistry, P.E.S’s Rajaram and Tarabai Bandekar College of Pharmacy, Ponda-Goa., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 512-516Abstract
Many infectious diseases in ancient times have been treated using herbal drugs. Today efforts are made for the discovery of the herbal components from plants possessing antimicrobial properties. Herbal drugs are widely used for treatment of various diseases, and they play an important role in health care considerations. Rhizome of Inchnocarpus frustescens were extracted, phytochemically investigated and were subjected to antibacterial as well as antifungal screening by Disk Diffusion Method. The Minimum Inhibitory Concentration (MIC) was also performed by two-fold tube dilution method. Three compounds were isolated and identified as n-nonadecanyl benzoate (1), benzocosanyl arachidate (2), and Quercetin (3). The result of phytochemical investigation showed that compound (3) is new isolated the first time from rhizomes; and compounds (1)and (2) are isolated from genus Ichnocarpus frutescens form other morphological parts earlier. Further antimicrobial tests indicated that the ethanolic extract inhibited the growth of all microorganisms and most extracts showed promising degree of antimicrobial activity. The results were compared with standard antimicrobial agents (Erythromycin and Fluconazole), Thus providing evidence for the potential use of these crude extract in the treatment of bacterial and fungal infections.Keywords
Antimicrobial activity, Disc diffusion, Herbal medicine, Phytochemically, Minimum inhibitory concentration.References
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- Development and Validation of a Novel, Cost Effective UV Spectrophotometric Method for Simultaneous Estimation of Cilnidipine and Olmesartan
Abstract Views :72 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, P.E.S.’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa,, IN
1 Department of Pharmaceutical Chemistry, P.E.S.’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Goa,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 863-869Abstract
Cilnidipine is a novel, dihydropyridine class of calcium-channel blocker. It prevents intracellular calcium influx and results in vasodilatation. Olmesartan medoxomil is a synthetic imidazole derivative prodrug and angiotensin II type blocker used to manage hypertension. The combination of cilnidipine and olmesartan medoxomil is used in the treatment of hypertension. Literature review revealed that there are many analytical methods involving HPLC and some using UV for estimation of the two drugs individually and in combination. UV spectrophotometric methods have the advantage of being simple, cost effective and rapid. Hence it was thought worthwhile to develop a simple, cost effective UV spectrophotometric method for simultaneous estimation of cilnidipine and olmesartan medoxomil employing the Absorption Correction principle. In this method, water: methanol (80:20,v/v) was used as the diluent. From the UV overlain spectra of both the drugs 257nm and 365nm were selected as wavelengths for analysis. The method was validated using the ICH guidelines. The linearity range was established from 10-100μg/ml (r2= 0.999) for cilnidipine and 10-80 μg/ml (r2= 0.998) for olmesartan medoxomil. The developed method was found to be accurate as % recovery at 80%, 100% and 120% levels were found to be within the acceptance criteria. The results for intra-day and inter-day precision were within acceptance limits of % RSD ˂ 2%. The method was found to be sensitive and robust. The developed method was applied in the estimation of Cilnidipine and Olmesartan in tablet dosage form and % assay was found to be 100.75% and 103.8% for the two drugs respectively. Hence the developed method can be employed as a simple, cost effective, quality control analytical method for simultaneous estimation of the two drugs in bulk and in combination.Keywords
Cilnidipine, Olmesartan medoxomil, UV spectroscopy, Absorption Correction method, Validation, ICH guidelines.References
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