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Sanjib Das ¹, Soma Chanda ²

Affiliations
1 Khidirpur Rahmania High Madrasah, Alipurduar-735213, West Bengal, IN
2 Department of Botany, Mahishadal Raj College, Purba Medinipur-7216282, West Bengal, IN

Abstract

Due to population growth and increase in demand for various products of natural sources, exploitation has escalated to unprecedented heights. Besides growing a few crops, economically weaker people frequently collect wild edible plants for food and other plants from natural habitats to meet their subsistence needs. Investigation on wild edible plants as supplementary food resources holds promise since these plants often have medicinal properties of excellence. In view of this the present work was undertaken during 2016-2017 following standard ethnobotanical methods in Kodalbasti forest village under Chilapata forested areas of Alipurduar district of West Bengal, India. It is about 22 km away from Alipurduar and is a tourist destination and a part of Chilapata forest. The village is lying between 95o 15´ E and 93o 20´ North. Wild edible plants refer to the species that are neither cultivated nor domesticated but are available from their natural habitat and used as a sources of food and vegetables. The food plants are mainly used by the local inhabitant like- Rabha, Meach, Kooch, Rajbanshi, Santhal, Nepali, Kharia, Munda, Oraon.

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Sanjib Das ¹, R. C. Das ², S. H. Bhosale ², Ashish A. Gawai ¹

Affiliations
1 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-7861004, Assam, IN
2 Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, IN

Abstract

A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K₂CO₃. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.

Keywords

Schizophrenia, Atypical Antipsychotics, Coumarinoacetamides.

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