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Singh, Sanchita
- Synthesis and Antimicrobial Activities of Zn (II) Complex of 2,5-Diamino-1,3,4-Thiadiazole
Authors
1 Department of Chemistry, Agra College, Agra, U.P., IN
2 Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Research Journal of Science and Technology, Vol 5, No 4 (2013), Pagination: 462-465Abstract
Aim:
The ligands contain O, N, S-Sequence and their metal complexes have their various chemical and structural characteristics and their wide application in the field of pharmacology. The extreme efforts have been made to design novel drug to strains of resistant micro-organisms. This has required the need to search for more efficient drugs.
The Zn (II) metal complexes with a tridentate ligand 2,5-diamino-1,3,4-thiadiazole has been prepared by cyclisation of bithiourea in a 3% hydrogen peroxide medium. 2,5-diamino-1,3, 4-thiadiazole acts as neutral tridentate ligand and coordinates through the sulphur atom and nitrogen of the amines. The complexes are non-electrolyte in DMF. The complexes exhibited octahedral geometry. The antimicrobial activities of ligand and its complexes were screened using sensitivity test, minimum inhibition concentration and minimum bacterial concentration method. Metal chelates showed greater antimicrobial activities as compared to the control and the ligand. The metal chelates and the ligand did not exhibited activity against Aspergillus niger and Penicillin species.
Methods:
Elemental analyses, IR spectra, magnetic susceptibilities by using Faraday Balance, molar conductance by using Genway 4200 conductivity meter. Metal estimation by using Alpha 4 Atomic Absorption Spectrophotometer. Thin layer chromatography was carried out using TLC plate coated with silica gel.
Results:
The results of the elemental analyses are in good agreement with those calculated for the suggested formulae, 1:2 (M: L) solid chelates are isolated and found to have the general formulae [(ML2)] X2; M=Zn (II) (X=Cl).
The IR spectra revealed that the ligand L is a neutral tridentate ligand. It coordinated to the metal ions via the nitrogen of the amines and sulphur atom. The molar conductance value of the Zn (II) complex was low which indicate the nonelectrolytic nature of the complex. The ligand and metal complexes show antimicrobial effect against the tested organism species except against molds of penicillin and Aspergillius. Niesseria gonorrhoea was probably the most sensitive organism to the 2,5-Diamino-1,3,4-Thiadizole and its metal complexes. Metal complexes showed greater activity against some of the micro-organisms compared to the parent compounds
Conclusion:
In this paper we conclude from combined results of the chemical and physical analysis that the ligand (2,5-diamino-1,3,4-thiadiazole) coordinated with Zn. The metal complexes possess better physical properties than the parent compound. Metal complex of 2,5-diamino-1,3,4-thiadiazole would be a better therapeutic drug for antibacterial treatment.
Keywords
Zn (II) Complex, Cyclisation, 2,5-Diamino-1,3,4-Thiadiazole, Antimicrobial Activities.- Synthesis and Antimicrobial Activity of Zn(II) and Fe(II) Complexes Derived from Enamine
Authors
1 Department of Chemistry, Agra College, Agra, U.P, IN
2 Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Research Journal of Engineering and Technology, Vol 5, No 4 (2014), Pagination: 178-183Abstract
The Zn(II) and Fe(II) Complexes were prepared by the action of equimolar ethanolic solutions with the ligands (HL1, HL2 and HL3) with ethanolic metal solutions. Where HL1= 4-N,N-diethylamine-pent-3-ene-2-one, HL2=4-N,N-di npropylamine- pent-3-ene-2-one and HL3=4-N,N-dicyclohexylamine-pent-3-ene-2-one.
The complexes prepared, were characterized by IR, UV and atomic absorption spectroscopy. The metal complexes and Ligands were screened against Escherichia coli and Staphylococcus aureus bacteria to assess their antimicrobial activity by disc diffusion method. The Ligands were absolutely inactive against bacteria where as the complex of Zn (HL1) has significant action on both bacteria, which show a good potential as bactericide and other complexes have normal antiseptic character.
Keywords
Zn(II) and Fe(II) Complexes of Enamine, Antimicrobial Activity.- Synthesis, Characterization and Antimicrobial Activity of Co(II), Ni(II), Cu(II) and Zn(II) Complexes N- O- S Donor Ligands
Authors
1 Department of Chemistry, Agra College, Agra, U.P, IN
2 B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 4, No 4 (2014), Pagination: 174-177Abstract
The Co(II), Ni(II), Cu(II) and Zn(II) complexes of the composition 1:1:1 molar ratio, (ML1L2) (where L1=diphenylamine-2-mercapto-2-carboxylic acid and L2=2-furyl glyoxalanthranilic acid have been synthesized and characterized by elemental analyses, H-NMR, IR, electronic spectral data and magnetic susceptibility measurements. The synthesized ligands and their metal complexes were screened for their antimicrobial activity against two bacteria Staphylococcus aureus (gram +ve) and Escherichia coli (gram -ve) and two fungi Aspergillus niger and Apergillus flavus by Serial Dilution Method. Metal complexes are more active than their ligands.Keywords
Mixed Ligand Complexes, Antimicrobial Activity.- Synthesis, Characterization and Antimicrobial Activity of Cu(II),Co(II), Ni(II) and Zn(II),Complexes with O-N Donor Ligand
Authors
1 B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
2 Department of Chemistry, Agra College, Agra, U.P, IN
Source
International Journal of Technology, Vol 4, No 2 (2014), Pagination: 283-286Abstract
The complexes of the type MLXn, where M= Cu(II), Co(II), Ni(II), Zn(II) and X= H2O/Cl and L is the schiff base ligand prepared from 2,4-dihydroxy-5-Acetylacetophenone and 1,4-diaminobutane have been synthesized. All complexes isolated in solid, are stable in air and characterized by the elemental analysis, metal content determination, magnetic measurements, thermo gravimetric analysis (TGA), IR, and electronic spectral data. The physicochemical data suggest a pseudo octahedral structure to Cu(II) and an octahedral for Co(II), Ni(II), and Zn(II) complexes. The ligand field parameters have been calculated and related to the electronic environment. The Schiff base and its complexes were screened for their antimicrobial activities against various bacteria and fungi.
Keywords
Metal Complexes, Schiff Base, TGA (Thermo Gravimetric Analysis) Magnetic Study, and Antimicrobial Activity.- Solubility of Some Pyrimidine Derivatives in Methyl-Alcohol at Different Temperatures
Authors
1 School of Applied Sciences, Singhania University, Pacheri Bari, Jhunjhunu (Raj.), IN
2 Department of Chemistry, Agra College, Agra, U.P, IN
3 Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 2 (2017), Pagination: 186-190Abstract
The solubility of some of Pyrimidine derivatives in methyl alcohol was measured by gravimetrical method at different temperatures (293.15 to 313.15 K) under atmospheric pressure. The solubility data were comprised with temperature by Apelblat equation. Some thermodynamic parameters such as dissolution enthalpy, and Gibbs' free energy of dissolution and entropy were evaluated from solubility data.Keywords
Pyrimidine Derivatives, Solubility Data and Thermodynamic Parameters.- Synthesis of Some Chalcone and their Heterocyclic Derivatives as Potential Antimicrobial Agents:A Review
Authors
1 School of Applied Sciences Singhania University, Pacheri Bari, Jhunjhunu (Raj.), IN
2 Department of Chemistry, Agra College, Agra, U.P, IN
3 Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 2 (2017), Pagination: 225-239Abstract
The Chalcone is aromatic compounds that forms the central core for different necessity of biological compounds, and are prepared by Claisen-Schmidt condensation of equimolar concentrations of arylaldehydes and acetophenones which are generally base catalysed. Chalcones are considered as the precursors of flavonoids and isoflavonoids. as the precursors the precursors of flavonoids and isoflavonoids. Chemically, chalcones are 1,3-diaryl-2-propen-1-ones in which two aromatic rings are joined by a three carbon bridge having a carbonyl moiety and α,β unsaturation. One of the most important classes of chalcones is the ring closure reactions with hydrazine, phenyl hydrazine, guanidine, urea etc. forming heterocyclic derivatives of chalcones. Both chalcones and their heterocyclic derivatives have a large number of pharmacological activities such as anti antimicrobial, antifungal, antibacterial, antioxidant, inflammatory, antitumor, anticancer, anti mitotic, anti leishmanial, anti-malarial, anti tubercular, antiviral, cytotoxic, etc. In this research paper (review) the efforts have been made to show some synthesis and biological activities of chalcones and their derivatives.Keywords
Chalcones, Claisen-Schmidt Condensation, Antimicrobial Activity, Heterocyclic Derivatives.- Synthesis and Physico Chemical Studies of Some Chalcone and Their Derivatives as Potential Antimicrobial Agents
Authors
1 School of Applied Sciences, Singhania University, Pacheri Bari, Jhunjhunu (Raj.), IN
2 Department of Chemistry, Agra College, Agra, U.P, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1155-1159Abstract
The Chalcone is an aromatic compound that forms the central core for various necessities of biological compounds. The Chalcone is synthesized by Claisen - Schmidt condensation of benzaldehyde derivatives with acetophenone derivatives in dilute ethanolic sodium hydroxide solution at room temperature. The structures of synthesized compounds were investigated by IR Spectroscopy, NMR Spectroscopy and Mass Spectrometry. The antimicrobial activity of the synthesized was evaluated by Filter Paper Disc diffusion Method. The compound 1b showed excellent activity against S. aureus at both concentration i.e. 500μg/ml and1000 μg/ml.Keywords
Chalcone Derivates, Antimicrobial Agents.- Synthesis, Characterization and Antimicrobial Activities of Cu(II), Ni(II) and Co(II) Complexes with N–O Donor Ligand.
Authors
1 Department of Chemistry, Agra College, Agra, U.P, IN
2 Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 4 (2014), Pagination: 205-210Abstract
The complexes of Cu (II), Ni (II) and Co (II) with a Schiff base derived from 5-bromo-3-fluorosalicylaldehyde with 4, 4'-diaminodiphenyl methane in the molar ratio 2:1 were synthesized and characterized by several techniques, including elemental analysis, IR, electronic, conductivity, LC-MS, 1H NMR, and magnetic susceptibility measurements were used to characterize the isolated ligand and its metal complexes. The ligand behaves as dibasic with N2O2 tetra dentate sites and two ligands coordinate with two metal ions to form binuclear complexes. The 1H-NMR data reveal that the Schiff base found in enol-iminic form. The binding site is nitrogen atoms of azomethine groups and oxygen atoms of the phenolic groups. The substitution in phenyl ring of the complexes produces shift in the azomethine υ(C=N) stretching vibrational frequency. The non-electrolytic behavior of complexes indicates the absence of counter ions. EPR spectra provided further information to confirm the binuclear structure. On the behalf of electronic spectral data and magnetic susceptibility measurements, the suitable geometry has been proposed for each complex. The Schiff base ligand and metal complexes were tested against four pathogenic bacteria (E. coli and K. pneumoniae) as Gram-negative, (S. aureus and B. subtilis) as Gram+positive, and pathogenic fungi (A. fumigatus) to assess their antimicrobial properties.Keywords
Anti-Microbial Activity, Schiff Base.- Synthesis, Characterization and Antimicrobial Activities of Some New Amino-Pyrimidine Derivatives
Authors
1 School of Applied Sciences Singhania University Pacheri Bari, Jhunjhunu (Raj.), IN
2 Department of Chemistry, Agra College, Agra, U.P, IN
3 B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 167-171Abstract
In the present work, an efficient synthesis of some new Amino-Pyrimidine Derivatives has been created through response of chalcones of cyclic imides and guanidine nitrate in presence of neutral alumina. The new synthesized amino-pyrimidines showed synergistic significant activities against Candida albicans and Aspergillus nigerfungal strains.Keywords
Amino-pyrimidines, Chalcones, Antimicrobial Activity.References
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