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Shah, Samir
- Evaluation of Anti-Asthmatic Activity of Centratherum anthelminticum Linn. in Experimental Animals
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Authors
Affiliations
1 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol - 388 315, Dist-Anand, Gujarat, IN
1 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol - 388 315, Dist-Anand, Gujarat, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 1 (2017), Pagination: 19-24Abstract
Purpose: The aim of study was to evaluate the scientific basis for the traditional use of Centratherum anthelminticum Linn. seeds in asthma.
Design/Methodology: In the present study, methanolic extract of Centratherum anthelminticum seeds was evaluated for preliminary phytochemical study and antiasthmatic activity by Histamine induced preconvulsion dyspnoea (PCD), Mast cell degranulation (MCD) by compound 48/80 and Egg albumin induced asthma at different dose levels. In PCD animals were divided into three groups and % increase in time of PCD was recorded. In MCD, animals were divided into seven groups and % protection of mast cells was measured. In egg albumin induced asthma, animals were divided into five groups. Broncho alveolar fluid was collected and evaluated. Dunnett's t-test and post hoc test were used for statistical analysis.
Findings: Phytochemical study revealed the presence of flavonoids, proteins, Saponins, tannins, steroids, glycosides and phenols. The results of pharmacological studies showed that the methanolic extract of C.anthelminticum significantly decreased bronchospasm induced by histamine and protected the mass cell degranulation as compared to the control groups. It also significantly decreased the total leukocyte and different WBC count in egg albumin induced asthma.
Conclusions: Methanolic extract of C.anthelminticum seeds possess antiasthmatic activity. Antiasthmatic action of C.anthelminticum could be due to its antihistaminic, mast cell stabilizing property and preventive effect on infiltration of inflammatory cells.
Keywords
Centratherum anthelminticum Linn., Histamine Induced Preconvulsion Dyspnoea (CPD), Mast Cell Degranulation (MCD), Egg Albumin Induced Asthma, Compound 48/80.Full Text
References
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- A Review:Coix lacryma iobi L.
Abstract Views :570 |
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Authors
Affiliations
1 Department of Pharmaceutical Science, Sardar Patel University, Vallabh Vidhyanagar, Gujarat, IN
2 Department of Pharmaceutical Chemistry, Sardar Patel College of Pharmacy, Bakrol, Gujarat, IN
3 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol, Gujarat, IN
1 Department of Pharmaceutical Science, Sardar Patel University, Vallabh Vidhyanagar, Gujarat, IN
2 Department of Pharmaceutical Chemistry, Sardar Patel College of Pharmacy, Bakrol, Gujarat, IN
3 Department of Pharmacology, Sardar Patel College of Pharmacy, Bakrol, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 4 (2017), Pagination: 248-252Abstract
The ischolar_mains and seeds of Coix lacryma-jobi L.are utilized for Medicinal, Pharmaceutical, Cosmetic Preparations and Dietary Supplements.There are two main varieties of the species, one wild and one cultivated. The wild variety of Coix lacryma-jobi var. lacryma-jobi has hard-shelled, pearly white, oval structures used as beads for making rosaries, necklaces and other objects. The cultivated variety Coix lacryma-jobi var. ma-yuen is harvested as a cereal crop, has a soft shell, and is used medicinally in parts of Asia. World-wide, this plant is best known for those pods (pericarps), which have a hole naturally occurring at each end, making them a useful source of beads for stringing.Seeds stringing is known "VAIJANTI MALA". The seeds (caryopses) of Coix lacryma-jobi L. are used as a source of food. Coix is the common name for the Chinese medicinal material Coix lacryma-jobi L. seed (Health Benefits of Job’s tears). Seed of Coix lacryma-jobi L.contains 50-79 % Starch,16-19 % Proteins, 2-7% Fixed Oil, Lipids (5.67%Glycolipid, 1.83% Phospholipid, Sterols), Fatty acids (Palmitic acid (PubChem CID:985), Steric acid(PubChemCID:5281), Oleic acid (PubChem CID: 445639), and Linoleic acid (PubChem CID: 5280450).This plant possess many traditional uses such as decrees blood cholesterol level, anti – inflammatory, anti – oxidant, hypolipidemic, anti-cancerand mensuration disorder in women etc. Coix lacrymajobi L. plant has significant medicinal value in human. This review helps to evaluate and establish the various medicinal use of plant in various diseases.Keywords
Coix lacryma-jobi, Poaceae, Phytonutrients, Starch, Lipid, Protein, Fixed Oil.
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