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Saminathan Kayarohanam ¹, Vetriselvan Subramaniyan ², Ashok Kumar Janakiraman ³, S. J. Madhan Kumar ³

Affiliations
1 Geomatika University College Kuala Lumpur, 54200, MY
2 Department of Pharmacology, MAHSA University, 42610, MY
3 UCSI University, Kuala Lumpur, 56000, MY

Abstract

Aim: To investigate the antioxidant, antidiabetic, and antihyperlipidemic activities of Dolichandrone atrovirens in albino wistar rats. Methods and Material: Bark and leaf part of Dolichandrone atrovirens were extracted with water and methanol. Swiss albino wistar rats were used to evaluate the in vivo effects of streptozotocin induced body weight loss, oxidative stress, hyperglycemia and hyperlipidemia. Statistical analysis : Data were analysed by One - way ANOVA, followed by Turkey –Kramer Multiple Comparison Test. Results: Dolichandrone atrovirens extract treated animals demonstrated significant increase in body weight, decreased blood glucose levels, glycosylated haemoglobin and changes in other biochemical parameters levels when compared to diabetic control rats.

Keywords

Dolichandrone atrovirens, Streptozotocin, in Vivo Activity, Antidiabetic.

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Chew Khe Jiea ¹, Shivkanya Fuloria ², Vetriselvan Subrimanyan ³, Mahendran Sekar ⁴, Kathiresan V. Sathasivam ⁵, Saminathan Kayarohanam ⁶, Yuan Seng Wu ⁷, Venkata Sathya Saiappala Raju Velaga ⁸, Ashok Kumar Janakiraman ⁹, Mohammad Nazmul Hasan Maziz ³, Neeraj Kumar Fuloria ¹⁰

Affiliations
1 Faculty of Pharmacy, AIMST University, Kedah 08100,, MY
2 Faculty of Pharmacy, AIMST University, Kedah 08100, MY
3 Faculty of Medicine, Bioscience and Nursing, MAHSA University, Bandar Saujana Putra 42610,, MY
4 Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh 30450, MY
5 Faculty of Applied Science, AIMST University, Kedah 08100,, MY
6 Faculty of Bio-economy and Health Sciences, Geomatika University College Kuala Lumpur 54200,, MY
7 Centre for Virus and Vaccine Research & Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Subang Jaya, Selangor,, MY
8 Faculty of Pharmacy, MAHSA University, Bandar Saujana Putra 42610,, MY
9 Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, MY
10 Faculty of Pharmacy, AIMST University, Kedah 08100,

Abstract

Plants are the natural source for the antioxidants from plants source is boon for the investigators. Present study was aimed to study the antioxidant activity and phytochemical screening of Cananga odorata (Lam.) Hook. f. & Thomson extract. Study involved preparation hydroalcoholic extract of Cananga odorata leaves (HECOL) using maceration method, followed by its phytochemical screening and antioxidant activity. The HECOL was subjected to determination of total phenolic content (TPC) and total flavonoid content (TFC), and DPPH (1,1-Diphenyl-2-picryl hydrazyl) radical scavenging assay for determination of antioxidant activity. Maceration of C. odorata using hydroalcoholic solvent offered dark brown colored HECOL. Phytochemical screening of HECOL exhibited presence of carbohydrates, mucilage, fats and oils, volatile oils, anthraquinone glycosides, flavonoids, alkaloids, tannins and phenolic compounds. For TPC the gallic acid equivalent of HECOL was found to be 0.507 mg GAE/g. Whereas for TFC, the rutin equivalent of HECOL was found to be 0.2224mg RE/g. The antioxidant activity of HECOL was estimated to be 120.44μg/ml (IC50). Based on the experimental results, present study concludes that HECOL possess the significant antioxidant potential. This study also recommends that antioxidant activity potential of C. odorata leaves should be further explored using different solvent extracts.

Keywords

Canaga odorata, total phenolic content, gallic acid, total flavonoid content, antioxidant activity.

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