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Shivhare, S.C.
- formulation of Povidone Iodine Vaginal Suppository Containing Lacto Bacillus Spores.
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Authors
Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
Source
Asian Journal of Pharmaceutical Research, Vol 3, No 1 (2013), Pagination: 6-9Abstract
Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent Povidone iodine. The second objective was to establish a stable clindamycine suppositiry alone with Lactic acid Bacillus Spores for vaginosis.Keywords
Vaginosis, Lactic Acid Bacillus Spores, Povidone Iodine, Formulation, Viability, Stability
References
- Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, 2nd ed. A practical approach to infectious diseases. Boston: Little, Brown and Company; 1986. p.385-421.
- Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am-J Obstet Gynecol 1973;117:1034-40.
- Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger;1986.p.9-34.
- Ledger WJ. Antimicrobial agents. In: Ledger WJ,2nd ed. Infections in the female. Philadelphia: Lea & Febiger;1986.p.95- 126.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:10-11.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179-83.
- McFarland LV. Beneficial microbes: health or hazard? Eur J Gastroenterol Hepatol 2000;12:1069-1071.
- Gionchetti P, Rizzello F, Venturi A, Campieri M. Probiotics in infective diarrhoea and inflammatory bowel diseases. J Gastroenterol Hepatol 2000;15:489-493.
- Larsen B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993;36:107-121.
- Redondo-Lopez V, Cook RL, Sobel JD. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis 1990; 12:856-872.
- Hiller SL. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998;14(suppl 1):17-21.
- Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect 2000;2:543- 546.
- Sobel JD. Vaginitis. N Engl J Med 1997;337:1896-1903.
- McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000;55(suppl 5):1-19.
- Sweet RL. Role of bacterial vaginosis in pelvic inflammatory diseases. J Infect Dis 1995; 20(suppl 2):271-275.
- Sooper DE. Bacterial vaginosis and postoperative infections. Am J Obstet Gynecol 1993; 169:467-469.
- Van de Wijgert, J.H.H.M., Mason, P.R. and Gwanzura, L. et al. Intravaginal practices, vaginal £ora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J. Infect. Dis. 2000;181,587-594.
- Chaim, W., Mazor, M. and Leiberman, J.R. (1997) The relationship between bacterial vaginosis and preterm birth. Arch. Gynecol. Obstet.1997;259:51-58.
- Reid G. and Bruce, A.W. Selection of Lactobacillus strains for urogenital probiotic applications. J. Infect. Dis. 2001;183(Suppl.1);77-80.
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- Sanae K, and Nattha K, Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus, World Academy of Science, Engineering and Technology 2009;(31):630-633.
- Formulation development and release studies of indomethacin suppositories, ML sah, TR Saini, short communications, Ind. J. pharm. Sciences 2008;70(4):498-501.
- Naikwade Sonali R, Kulkarni Pratibha P, Jathar Shripad R, Bajaj Amrita N. DARU 2008; 16 (3):119-127.
- A Review: Natural Skin Lighting and Nourishing Agents
Abstract Views :1158 |
PDF Views:0
Authors
Affiliations
1 Mahatma Jyoti Rao Phoole College of Health Care and Allied Sciences, MJRP University, Jaipur Rajasthan, IN
2 Rani Dhullaiya Memorial Ayurvedic College & Hospital, Bhopal Madhya Pradesh, IN
3 Swami Vivekanand College of Pharmacy, Indore Madhya Pradesh, IN
1 Mahatma Jyoti Rao Phoole College of Health Care and Allied Sciences, MJRP University, Jaipur Rajasthan, IN
2 Rani Dhullaiya Memorial Ayurvedic College & Hospital, Bhopal Madhya Pradesh, IN
3 Swami Vivekanand College of Pharmacy, Indore Madhya Pradesh, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 4, No 1 (2013), Pagination: 21-25Abstract
Abstract: In the present review article many depigmenting or skin lightening as well as nourishing agents are discussed, including their historical background, biochemical characteristics, type of inhibition and activators from various sources. In this article authors have tried to highlights the mechanism and role of Tyrosinase in melanin formation, which pigmenting the skin, with the various important natural agents which altering pigmentation and nourishing the skin like Alpha-Arbutin, Kojic Acid, Licorice Extract, Mulberry, Glycolic Acid, Lactic Acid, Lemon Juice Extract, Vitamin A, Vitamin C, Emblica, Aloe Vera Extract, Grape Seed Extract, Green Tea Extract, Alfalfa Extract, Caviar Extract, Cucumber Fruit extract, Glycerine, Hydrolyzed Soya Protein, Niacin amide, Sugar Cane extract, Safflower seed Oil, Salicylic acid, Squalane, Vitamin E, Watercress extract their sources brief description and the advantages.Keywords
Whitening, Tyrosinase Inhibitors, Natural Lighting and Nourishing Agents.References
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- Kim Y J, Uyama H. Tyrosinase inhibitors from natural and synthetic sources: Structure, inhibition mechanism and perspective for the future. Cell Mol. Life Sci. 2005; 62: 1707–23
- Parvez S, Kang M, Chung HS, Bae H. Naturally occurring tyrosinase inhibitors: Mechanism and applications in skin health, cosmetics and agriculture industries. Phytother. Res. 2007; 21: 805–16.
- Hanamura T, Uchida E, Aoki H. Skin-lightening effect of a polyphenol extract from Acerola (Malpighia emarginata DC.) fruit on UV-induced pigmentation. Biosci. Biotechnol. Biochem. 2008; 72: 3211–18.
- Formulation of Clindamycine hydrochloride Vaginal Suppository Containing Lacto Bacillus Spores
Abstract Views :487 |
PDF Views:65
Authors
Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 1 (2013), Pagination: 5-7Abstract
The present research and study is directed to Anti-microbial and lactic acid bacillus combination in a comprising pharmaceutical acceptable carrier and the methods for treating fungal, bacterial, protozoal and yeast infection. Some of the most common pathogens associates with invasive fungal infections are the opportunistic yeast, such as Candida spp. and Asppergillus spp. thousands of Candida spp cells can be present in an individual, primarily in the gastrointestinal tract, as a harmless commensal organism. However, Candida spp., such as C.albicans, cause oppotunistics fungal infections. Infections can be localized such as a vaginal infection or an oral infection, both of which cause a considerable degree of discomfort. The objective of this study was to develop a vaginal suppository containing lacti acid bacillus spores. Further the present research study provided the combination of anti infective drug Clindamycine Hydrochloride with micro organism lactic acid bacillus spores in a pharmaceutical formulation as suppository.Keywords
Vaginosis, Lactic acid Bacillus Spores, Clindamycine Hydrochloride, Formulation, Viability Stability.References
- Penn RL. Gynecological and obstetrical infections. In: Reese RE, Gordon Douglas Jr. R, 2nd ed. A practical approach to infectious diseases. Boston: Little, Brown and Company; 1986. p.385-421.
- Thadepalli H, Gorbach SL, Keith L. Anaerobic infections of the female genital tract; bacteriologic and therapeutic aspects. Am-J Obstet Gynecol 1973;117:1034-40.
- Ledger WJ. Micro-organisms that cause infection. In: Ledger WJ, ed. Infections in the female. 2nd ed. Philadelphia: Lea & Febiger;1986.p.9-34.
- Ledger WJ. Antimicrobial agents. In: Ledger WJ,2nd ed. Infections in the female. Philadelphia: Lea & Febiger;1986.p.95- 126.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:10-11.
- Bleker OP, Folkertsma K, Dirks-Go SIS. Diagnostic procedures in vaginitis. Eur J Obstet Gynecol Reprod Biol 1989;31:179-83.
- McFarland LV. Beneficial microbes: health or hazard? Eur J Gastroenterol Hepatol 2000;12:1069-1071.
- Gionchetti P, Rizzello F, Venturi A, Campieri M. Probiotics in infective diarrhoea and inflammatory bowel diseases. J Gastroenterol Hepatol 2000;15:489-493.
- Larsen B. Vaginal flora in health and disease. Clin Obstet Gynecol 1993; 36:107–121.
- Redondo-Lopez V, Cook RL, Sobel JD. Emerging role of lactobacilli in the control and maintenance of the vaginal bacterial microflora. Rev Infect Dis. 1990; 12:856–872.
- Hiller SL. The vaginal microbial ecosystem and resistance to HIV. AIDS Res Hum Retroviruses 1998;14(suppl 1):17–21.
- Boris S, Barbes C. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect 2000;2:543– 546.
- Sobel JD. Vaginitis. N Engl J Med 1997;337:1896–1903.
- McGregor JA, French JI. Bacterial vaginosis in pregnancy. Obstet Gynecol Surv 2000;55(suppl 5):1–19.
- Sweet RL. Role of bacterial vaginosis in pelvic inflammatory diseases. J Infect Dis 1995; 20(suppl 2):271–275. 16. Sooper DE. Bacterial vaginosis and postoperative infections. Am J Obstet Gynecol 1993; 169:467–469.
- Van de Wijgert, J.H.H.M., Mason, P.R. and Gwanzura, L. et al. Intravaginal practices, vaginal £ora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J. Infect. Dis. 2000;181,587-594.
- Chaim, W., Mazor, M. and Leiberman, J.R. The relationship between bacterial vaginosis and preterm birth. Arch. Gynecol. Obstet.1997;259: 51-58.
- Reid G. and Bruce, A.W. Selection of Lactobacillus strains for urogenital probiotic applications. J. Infect. Dis. 2001;183(Suppl.1),S77- 80.
- Reid, G., Bruce, A.W. and Taylor, M. Instillation of Lactobacillus and stimulation of indigenous organisms to prevent recurrence of urinary tract infections. Microecol. Ther.1995; 23: 32-45.
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- Sanae K, and Nattha K, Formulation and Evaluation of Vaginal Suppositories Containing Lactobacillus, World Academy of Science, Engineering and Technology 2009;(31):630-633.
- Formulation development and release studies of indomethacin suppositories, ML sah, TR Saini, short communications, Ind. J. pharm. Sciences 2008;70(4):498-501.
- Naikwade Sonali R, Kulkarni Pratibha P, Jathar Shripad R, Bajaj Amrita N. DARU 2008; 16 (3):119-127.