Informatics Publishing Limited

Prabha Pillai ¹, Jem Prabhakar ², S. Thara ³, S. Lakshmi ¹

Affiliations
1 Division of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram – 695 011, Kerala, IN
2 Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram – 695 011, Kerala, IN
3 Division of Pathology, Regional Cancer Centre, Thiruvananthapuram – 695 011, Kerala, IN

Abstract

Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor whose activation plays immense role in cell proliferation, survival, differentiation and development. Activation of STAT3 relies on phosphorylation at tyrosine residues promoting dimerization and subsequent nuclear translocation and activation of transcription. This study explores the relation between STAT3 and activated STAT3 (p-STAT3) in malignancy of breast. A high expression of STAT3 was found in breast cancer compared to adjacent normal breast tissues. A significant correlation between STAT3 and p-STAT3 was also observed. We also examined possible associations of these biomarkers with various clinicopathological parameters of breast cancer patients. The results revealed that both STAT3 and p-STAT3 are strongly associated with some of the major risk factors of breast cancer. Our findings implicate that targeting STAT3 signalling pathway could be an effective therapeutic approach for breast cancer.

Keywords

STAT3, p-STAT3, Breast Cancer, Clinicopathological Features.

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S. Thara ¹, M. G. Sanal Kumar ², B. Bini ²

Affiliations
1 H.H.M.S.P.B. N.S.S. College for Women, Neeramankara, Thiruvananthapuram, Kerala, IN
2 Research Department of Zoology, N.S.S. College, Pandalam, Kerala-689 501, IN

Abstract

The present study was aimed to determine the length-weight relationship of fishes. The samples of fishes were collected from the catches of Shanghumugham and Valiyathura beaches during a period of one year from January to December 1991. The total length and weight of all the specimens were recorded to the nearest mm and mg respectively. The data were pooled and subjected to regression analysis, to determine the growth pattern of fishes. The length-weight relationship of Rastrelliger kanagurata revealed a linear relationship which can be represented as TW=3.2392 log TL-2.3777, the 'b' value of 3.2392. The linear relationships of Sardinella gibbosa revealed a regression equation of TW=1.47454 log TL-0.27006. Encrasicholina devisi also showed allometric growth rate, it has the 'b' value of 2.54733. The length-weight relationship of Nemipterus japonicas also reveals an allometric growth form. The 'b' value was found to be 1.56103. The linear relationship can be expressed as TW= 1.56103log TL-0.2365.

Keywords

Length-Weight Relationship, Rastrelliger kanagurata, Sardinella gibbosa, Encrasicholina devisi, Nemipterus japonicas.

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