Refine your search
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Shukla, S.
- Uranium Occurrence in Proterozoic Chilpi Group, near Kanhari, Kawardha District, Chhattisgarh
Abstract Views :235 |
PDF Views:78
Authors
Affiliations
1 Atomic Minerals Directorate for Exploration and Research, AMD Complex, Civil Lines, Nagpur 440 013, IN
2 Atomic Minerals Directorate for Exploration and Research, AMD Complex, Begumpet, Hyderabad 500 016, IN
1 Atomic Minerals Directorate for Exploration and Research, AMD Complex, Civil Lines, Nagpur 440 013, IN
2 Atomic Minerals Directorate for Exploration and Research, AMD Complex, Begumpet, Hyderabad 500 016, IN
Source
Current Science, Vol 107, No 3 (2014), Pagination: 364-367Abstract
No Abstract.Full Text
- Light Weight Freight Rolling Stock Bogie Frame:Design Methodology Validated with Field Oscillation Trials
Abstract Views :331 |
PDF Views:205
Authors
Affiliations
1 Govt. of India, Ministry of Railways, Research Designs and Standards Organisation, IN
1 Govt. of India, Ministry of Railways, Research Designs and Standards Organisation, IN
Source
International Journal of Vehicle Structures and Systems, Vol 9, No 4 (2017), Pagination: 245-250Abstract
Indian railway has improved the laden to tare weight ratio by producing lighter as well as higher strength bogie frame of freight rolling stock. Bogie frame is the crucial component of the rail vehicle which carries static load in the form of gross weight and dynamic loads arising from various track and wheel irregularities. The three piece freight vehicle bogie frame comprises two side frames and one bolster. The side frame; fitted with three piece bogie frame and responsible for the ride quality of the freight vehicle, is considered in present study. The locations suitable for weight reduction are found by finite element analysis (FEA), using side frame solid model in MSC FEA environment. International standards of the association of American railroad (AAR specification M-203) load cases and boundary conditions are deployed for analysis in the context of the operating scenario of Indian railways. Typical Indian railway track signatures are used as input for transient analysis. Time dependent stresses at critical speeds are used for fatigue strength evaluation as per Goodman diagram. The modified design is approx. 13.90% lighter and sustains 25.00 ton axle load in comparison of earlier 22.00 ton. Suggested topological changes have been compared by using frequencies of the initial and modified designs. Further, based on Indian railways running conditions, actual assessment and trial of the modified design bogie frame prototype has been carried out by Research Designs and Standards Organisation (RDSO). The results of the trial are found to be satisfactory and within the prescribed range.Keywords
Rail Vehicle, Side Frame, Axle Load, Solid Model, Goodman Diagram, Fatigue Strength.Full Text
References
- Truck Side Frame, Cast or Structural Design and Testing Specification, Association of American Railroad (AAR) M-203, 2007.
- Oscillation Trials of 25 t Axle Load Broad Gauge Bogie Open Wagon type GONDOLA 25t with up to Maximum Speed of 110 kmph in Empty and 85 kmph in Loaded Condition over CTC-PRDP Section of East Coast Railway, Report number MT-1383: 2014, Govt. of India, Ministry of Railways, Research Design and Standards Organisation, India.
- R.K. Luo, B.L. Gabbitas and B.V. Brickle. 1996. Dynamic stress analysis of an open-shaped railway bogie frame, Engg. Failure Analysis, 3(1), 53-64.
- Z. Ren, S. Sun, Q. Li and Z. Liu. 2011. Experimental studies of load characteristics of bogie frames for 350km/h EMUs, IMechE J. Rail & Rapid Transit, 226, 216-227. https://doi.org/10.1177/0954409711412012.
- S. Stichel and K. Knothe. 1998. Fatigue life prediction for an S-train bogie, Vehicle Sys. Dyn. Supplement, 28, 390-403. https://doi.org/10.1080/00423119808969573.
- D. Younesian, A. Solhmirzaei and A. Gachloo. 2009. Fatigue life estimation of MD36 and MD523 bogies based on damage accumulation and random fatigue theory, J. Mech. Sci. and Tech., 23, 2149-2156.
- https://doi.org/10.1007/s12206-009-0622-y.
- J.S. Kim. 2006. Fatigue assessment of tilting bogie frame for Korean tilting train: Analysis and static tests, Engg. Failure Analysis, 13, 1326-1337.
- S. Dietz, H. Netter and D. Sachau. 1997. Fatigue life predictions by coupling finite element and multi body systems calculations, Proc. ASME Design Engg. Tech. Conf., 1-9.
- Indian railways specification No. WD-17-CASNUB-22HS-BOGIE-92 (Revision-3) for CASNUB-22W, 22HS Cast Steel Bogies with Friction Damping Arrangement for Broad Gauge, 2006, RDSO, Ministry of Railways.
- S. Shukla, R. Gupta and N.S. Vyas. 2010. Weight reduction in an Indian railway CASNUB bogie bolster considering fatigue strength, Int. J. Veh. Str. and Systems, 2(3), 102-109. http://dx.doi.org/10.4273/ijvss.2.3-4.03.
- Programme of Tests to be Carried Out on Wagon with Steel Under Frame and Body (Suitable for Being Fitted With The Automatic Buffing and Draw Coupler) and on their Cast Steel Frame Bogies, ERRI B12/RP17, 1993, 7th Edition, European Rail Research Institute.
- Casting Details, Castings, Steels, Association of American Railroad (AAR) - M-201, 2007.
- J.E. Shigely. Mech. Engg. Design, McGraw-Hill Series in Mech. Engg., 10th Edition.
- Motive Power Units, Bogie and Running Gear, Bogie Frame Structure Strength Tests, UIC 615-4, 1994, International Union of Railways.
- V.K. Garg and R.V. Dukkipati. 1984. Dynamics of Railway Vehicle System.
- Third Report of the Standing Criteria Committee, Revision-l, TG-CR-4.2.3-1, May 2013, Government of India, Ministry of Railways, Research Design and Standards Organisation, India.
- UGS, NX 8.5, Users manual.
- User guide MSC FEA software 2010.
- Aldrin Induce Acute Toxicity at Enzymatic and m-RNA Expression Levels in Zebrafish
Abstract Views :240 |
PDF Views:0
Authors
Affiliations
1 Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat, IN
1 Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 1 (2018), Pagination: 48-58Abstract
Aldrin is a systematic toxicant, belongs to cyclodiene class of organochlorine pesticide and banned due to its toxic, bioaccumalative and persistent nature but still detected from environmental components. Present study includes the assessment of aldrin toxicity at two sublethal concentrations in zebrafish. A total 81 zebrafish were divided into three groups viz. group 1: Control, group 2 and 3: Exposed groups which were given 3 mg/mL and 6 mg/mL of aldrin, respectively for 24 hours. The markers of oxidative stress viz. antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) were examined in terms of biochemical activities and gene expression. Acute exposure of aldrin (both concentrations) caused significant alteration in antioxidant enzymes activities and gene expression in liver, kidney and brain tissues, which were more prominent in brain in concentration dependent manner. Study provides a baseline data to understand alterations in enzymatic activity and expression leading to toxic manifestation of aldrin in aquatic animals.Keywords
Aldrin, Gene Expression, Organochlorine, Oxidative Stress, Zebrafish.
References
- Jhamtani RC, Shukla S, Dahiya MS, Agarwal R. Forensic toxicology research to investigate environmental hazard. JFSCI. 2017a; 3(2): 001–4.
- Jhamtani RC, Shukla S, Dahiya MS, Agarwal R. Impact of co-exposure of aldrin and titanium dioxide nanoparticles at biochemical and molecular levels in zebrafish. Environ Toxicol Pharmacol. 2018; 58: 141–55. PMid: 29331773. https://doi.org/10.1016/j.etap.2017.12.021
- Costa LG. The neurotoxicity of organochlorine and pyrethroid pesticides. Lotti M, Bleecker ML. Eds. Occupational Neurology: Handbook of Clinical Neurology. 2015; 131(3): 135–48. https://doi.org/10.1016/B978-0-444-626271.00009-3
- Arant FS. Toxicty of aldrin to chickens. J Econ Ent, 1952; 45: 121. https://doi.org/10.1093/jee/45.1.121
- Fitzhugh OG, Nelson AA, Quaife ML. Chronic oral toxicity of aldrin and dieldrin in rats and dogs. Fd Cosmet Tox. 1964; 2: 551. https://doi.org/10.1016/S0015-6264(64)80354-0
- Lamai SL, Warner GF, Walker CH. Effects of dieldrin on life stages of the African catfish, Clarias gariepinus (Burchell). Ecotoxicol Environ Saf. 2001; 42: 22–9. PMid: 9931234. https://doi.org/10.1006/eesa.1998.1723
- Ressang AA, Titus I, Andar RS, Soedarmo D. Aldrin, dieldrin and endrin intoxication in cats. Comm Vet. 1958; 2: 71–88.
- Bachowski S, Kolaja KL, Xu Y, Ketcham CA, Stevenson DE, Walborg EF, Klaunig JE. Role of oxidative stress in the mechanism of dieldrin’s hepatotoxicity. Ann Clin Lab Sci. 1997; 27(3): 196–209. PMid: 9142372.
- Jhamtani RC, Shukla S, Dahiya MS, Agarwal R. Evaluation of acute effects of lead at sub-lethal concentrations in zebrafish. Res J Environ Toxicol. 2017b; 11: 97–103. https://doi.org/10.3923/rjet.2017.97.103
- Agarwal R, Raisuddin S, Tewari S, Goel SK, Raizada RB, Behari JR. Evaluation of comparative effect of pre‐and posttreatment of selenium on mercury‐induced oxidative stress, histological alterations and metallothionein mRNA expression in rats. J Biochem Mol Toxicol. 2010; 24(2): 123–35. PMid: 20143455.
- Shukla S, Jhamtani RC, Dahiya MS, Agarwal R. Oxidative injury caused by individual and combined exposure of neonicotinoid, organophosphate and herbicide in zebrafish. Toxicol Rep. 2017a; 4: 240–4. PMid: 28959645 PMCid: PMC5615116. https://doi.org/10.1016/j.toxrep.2017.05.002
- Slotkin AT, Seidler FJ. Oxidative and excitory mechanisms of developmental neurotoxicity: Transcriptional profiles for chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Environ Health Perspect. 2009; 117(4): 587–96. PMid: 19440498 PMCid: PMC2679603. https://doi.org/10.1289/ehp.0800251
- Jhamtani RC, Shukla S, Dahiya MS, Agarwal R. Assessment of environmental hazards caused by industrial effluent discharge using zebrafish as an aquatic biomarker. Curr Topics Toxicol. 2017c; 13: 105–12.
- Brammell BF, Wigginton AJ. Differential gene expression in zebrafish (Danio rerio) following exposure to gaseous diffusion plant effluent and effluent receiving stream water. Ame J Environ Stud. 2010; 6(3): 286–94.
- Organisation for economic co-operation and development. OECD guidelines for the testing of chemicals, Section 2. Effects on biotic systems; 2004.
- Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Ind J Biochem Biophys. 1984; 21(2): 130–2. PMid: 6490072.
- Sinha AK. Colorimetric assay of Catalase. Anal Biochem. 1972; 47: 389–94. https://doi.org/10.1016/0003-2697(72)90132-7
- Flohe L, Gunzler WA. Assays of glutathione peroxidase. Meth. Enzymol. 1984; 105(1): 114–21. https://doi.org/10.1016/S0076-6879(84)05015-1
- Lowry HW, Rosebrough NJ, Farr AL, Randall RJ, Protein measurement with folin phenol reagent. J Biol Chem. 1951; 193(1): 265–75. PMid: 14907713.
- Pfaffl MW. A new mathematical model for relative quantification in real-time RT–PCR. Nucl Acids Res. 2001; 29(9): e45. PMid: 11328886 PMCid: PMC55695. https://doi.org/10.1093/nar/29.9.e45
- Shukla S, Jhamtani RC, Dahiya MS, Agarwal R. A novel method to achieve high yield of total RNA from zebrafish for expression studies. Int J Bio. 2017b; 6(05): 5383–5.
- Banerjee BD, Seth V, Ahmed RS. Pesticide-induced oxidative stress: Perspectives and trends. Rev Environ Health. 2001; 16: 1–40. PMid: 11354540. https://doi.org/10.1515/REVEH.2001.16.1.1
- Shao B, Zhu L, Dong M, Wang J, Wang J, Xie H, Zhang Q, Du Z. and Zhu S. DNA damage and oxidative stress induced by endosulfan exposure in zebrafish (Danio rerio).Ecotox. 2012; 21: 1533–40. PMid: 22535316. https://doi.org/10.1007/s10646-012-0907-2
- Sakuragui MM, Paulino MG, Pereira CDS, Carvalho CS, Sadauskas-Henrique, Fernandes MN. Integrated use of antioxidant enzymes and oxidative damage in two fish species to assess pollution in man-made hydroelectric reservoirs. Environ Poll. 2013; 178: 41–e51. PMid: 23542355. https://doi.org/10.1016/j.envpol.2013.02.032
- Kitazawa M, Anantharam V, Kanthasamy AG. Dieldrininduced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells. Free Radic Biol Med. 2002; 31(11): 1473–85. https://doi.org/10.1016/S0891-5849(01)00726-2
- Kim BM, Lee JW, Seo JS, Shin KH, Rhee JS, Lee JS. Modulated expression and enzymatic activity of the monogonont rotifer Brachionus koreanus Cu/Zn- and Mn-superoxide dismutase (SOD) in response to environmental biocides. Chemosphere. 2015; 120: 470–8. PMid: .25260044 https://doi.org/10.1016/j.chemosphere.2014.08.042
- Jamaluddin S, Poddar MK. Role of brain regional GABA: Aldrin-induced stimulation of locomotor activity in rat. Neurochem Res. 2001; 26(4): 439–51. PMid: 11495356. https://doi.org/10.1023/A:1010915518292
- Bano Y. Effects of aldrin on serum and liver constituents of freshwater catfish Clarius batracus L. Proc Indian Acad Sci (Anim Sci.). 1982; 91(1): 27–32.
- Choi SI, Kim KS, Kim BY, Ahn SY, Cho HJ, Lee HK, Cho HS, and Kim EK. Decreased catalase expression and increased susceptibility to oxidative stress in primary cultured corneal fibroblasts from patients with granular corneal dystrophy type II. Ame J Pathol. 2009; 175(1): 248–61. PMid: 19497990 PMCid: PMC2708811 https://doi.org/10.2353/ajpath.2009.081001
- Hansen BH, Rømma S, Garmo ØA, Olsvik PA, Andersen RA. Antioxidative stress proteins and their gene expression in brown trout (Salmo trutta) from three rivers with different heavy metal levels. Compar Biochem Physiol C Toxicol Pharmacol. 2006; 143(3): 263–74. PMid: 16616685. https://doi.org/10.1016/j.cbpc.2006.02.010
- Karacca M, Varışlı L, Korkmaz K, Özaydın O, Percin F, Orhan H. Organochlorine pesticides and antioxidant enzymes are inversely correlated with liver enzyme gene expression in Cyprinus carpio. Toxicol Lett. 2014; 230(2): 198–207. PMid: 24583044. https://doi.org/10.1016/j.toxlet.2014.02.013
- Ahmad I, Hamid T, Fatima M, Chand HS, Jain SK, Athar M, Raisuddin S. Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure. Biochim Biophy Acta (BBA)Gen Sub. 2000; 1523(1): 37–48. https://doi.org/10.1016/S0304-4165(00)00098-2
- Bainy AC, Arisi AC, Azzalis LA, Simizu K, Barros SB, Videla LA, Junqueira VB. Differential effects of short‐term lindane administration on parameters related to oxidative stress in rat liver and erythrocytes. J Biochem Mol Toxicol. 1993; 8(4): 187–94. https://doi.org/10.1002/jbt.2570080404
- Jin Y, Zhang X, Shu L, Chen L, Sun L, Qian H, Liu W, Fu Z. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 2010; 78(7): 846–52. PMid: 20036412. https://doi.org/10.1016/j.chemosphere.2009.11.044
- Liu M, Liang Y, Chigurupati S, Lathia JD, Pletnikov M, Sun Z, Crow M, Ross CA, Mattson MP, Rabb H. Acute kidney injury leads to inflammation and functional changes in the brain. Journal of the Ame Soc Nephrol. 2008; 19(7): 1360–70. PMid: 18385426 PMCid: PMC2440297. https://doi.org/10.1681/ASN.2007080901
- Ikeda T, Murata Y, Quilligan EJ, Parer JT, Murayama T, Koono M. Histologic and biochemical study of the brain, heart, kidney and liver in asphyxia caused by occlusion of the umbilical cord in near-term fetal lambs. Ame J Obstet Gynecol. 2000; 182(2): 449–57. https://doi.org/10.1016/S0002-9378(00)70238-9