Informatics Publishing Limited

N. Prabhu ¹, M. Dev Anand ², S. Satish ³, C. K. Akhil ¹

Affiliations
1 Department of Mechanical Engineering, Kottayam Institute of Technology and Science (KITS), Chengalam East, Pallickathodu, Kottayam – 686585, Kerala, IN
2 Department of Mechanical Engineering, Noorul Islam Centre for Higher Education, Kumaracoil – 629180, Tamil Nadu, IN
3 Department of Electronics and Communication Engineering, Kottayam Institute of Technology and Science (KITS), Chengalam East, Pallickathodu, Kottayam – 686585, Kerala, IN

Abstract

Dynamics deals with not only forces but also torques necessary to lead to the motion of a system of bodies. The robot manipulators can also be approached from two different points of view: Dynamical analysis and dynamical synthesis. Dynamical analysis handles the equations of motion derivation of a specified manipulator. Two types of dynamical analysis problems exist: Direct dynamics and inverse dynamics. The computational efficiency of direct dynamics is not much as critical because it is utilized chiefly for computer simulations of a robot manipulator. Moreover, a competent inverse dynamic model turns into tremendously significant for real-time, model dependent control of a robot manipulator. A set of torque and/or force functions have to be functional at the actuated joints in the idea of generating that motion. These actuating torque and/or force functions rely not only on the spatial and attributes of the given path but also on the mass properties of the links, the pay load, the outwardly applied forces and so on. This paper deals with the dynamic analysis of a SCORBOT-ER V plus robot arm that is involved in performing victorious robotic manipulation task in its 3D workspace. This research considered mathematical dynamic model based on Lagrangian equations of motion and the result is compared with LabVIEW Software.

Keywords

Direct Dynamics, Inverse Dynamics, Lagrangien Equation, LabVIEW, Robot Manipulator

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S. Satish ¹, G. Sankara Aditya Sarma ¹, B. Ashok Reddy ¹, V. Sai Kishore ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur Dist-522415, A.P., IN

Abstract

The influence of Soapnut on the permeability of Eudragit RL100 films was studied with a view to develop a suitable rate controlling membranes for transdermal use. Dibutyl phthalate was incorporated at a concentration of 15% w/w of dry polymer as plasticizer. The dry free films were evaluated for various mechanical properties further the permeability characteristics of free films was studied using propranalol hydrochloride and diltiazem hydrochloride as model drugs. Both water vapour transmission and drug diffusion rate followed zero order kinetics. The soapnut powder showed a significant influence on the mechanical as well as permeability characteristics. This may be due to difference in the affinity of soapnut with the film former. From this study it was concluded that the plasticized free films of Eudragit RL100 prepared with soapnut can be used as rate controlling membranes to develop transdermal drug delivery systems.

Keywords

Soapnut, Eudragit RL100, Dibutyl Phthalate, Permeability, Diffusion.

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B. Ashok Reddy ¹, S. Satish ¹, G. Sankara ¹, Adithya Sarma ¹, V. Sai Kishore ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla -522101, IN

Abstract

The influence of solubility of drug in the dispersed phase (Acetone: Water Mixtures) employed in the preparation on the entrapment efficiency and drug release from ethyl cellulose microcapsules was studied. Propranolol hydrochloride was used as core and microcapsules were prepared by an emulsion solvent evaporation method. All the solvents gave discrete, large sized, free flowing spherical microcapsules. The microcapsules were evaluated for size analysis, drug content, microencapsulation efficiency, wall thickness, drug release characteristics, influence of solvent employed on entrapment efficiency and Propranolol hydrochloride release from microcapsules, surface characteristics. Propranolol hydrochloride release from the microcapsules, followed zero order kinetics and influenced by the size of the microcapsules and the solvent employed in their preparation. The Propranolol hydrochloride release rate from the microcapsules was found to be decreased with increased proportion of water in the dispersed phase. Among the solvents employed acetone: water mixture (92.5% v/v : 7.5% v/v) was found to be more suitable for slow release of Propranolol hydrochloride from ethyl cellulose microcapsules.

Keywords

Propranolol Hydrochloride, Microcapsules, Emulsion Solvent Evaporation, Entrapment Efficiency.

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Mohibul Hoque ¹, S. Satish ²

Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN

Abstract

Hyperlipidemia is a major cause of Atherosclerosis and the atherosclerosis-associated condition such as coronary heart disease ischemic cerebrovascular disease and peripheral vascular disease. The present study was carried out to investigate antihyperlipidemic properties of aqueous leaf extract of ciceracida (ALEC) against hyperlipidemia induced by high fat diet (HFD) in wistar albino rats. Wistar albino rats were divided in 6 groups of 6 rats in each. Group I received normal diet. Group II received high fat diet. Group III received a high fat diet supplemented with simvastatin 4mg/kg. Group IV received high fat diet supplemented with aqueous leaves extract of ciceracida 100 mg/kg. Group V received a high fat diet supplemented with aqueous leaves extract of ciceracida 250 mg/kg and Group VI received a high fat diet supplemented with aqueous leaves extract of ciceracida 500mg/kg for 30 days. At the end of the experiments on the 30^th, day blood samples was collected 4 h after the last dose of administration using light ether anesthesia. Blood samples were collected separately from retro orbital sinus puncture into sterilized dry centrifugation tubes. Blood serum was analysed for its hypolipidemic activity. Serum analysis showed decrease cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, atherogenic index, body weight, food intake and an increase cholesterol excretion and serum high density lipoprotein content was observed in the group III, IV, V and VI rats as compared to the group II rats, and there is no histopatholological alteration in rat aorta was seen. Thus it could be concluded that ALEC is potent antihyperlipidemic activity.

Keywords

Ciceracida Leaf, Lipoprotein, Hyperlipidemic Diet, Obesity.

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Mohibul Hoque ¹, S. Satish ²

Affiliations
1 JJT University, Jhunjhunu, Rajasthan, IN
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, IN

Abstract

Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4^th, 7^th and 10^th day similarly in sub acute study animals were tested for blood glucose level on 14^th, 21^th and 30^th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.

Keywords

Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.

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S. Mohan kumar ¹, S. Satish ¹

Affiliations
1 Dept. of Automobile Engg., Kumaraguru College of Tech., Coimbatore, IN

Abstract

Internal combustion engines are found to be extensively used in both mobile and stationary applications. The major drawbacks in diesel engines are the release of harmful gases like HC, CO, NO_x and PM into atmosphere. There is several pre combustion and post combustion techniques are available to control these emissions effectively. Although CO₂ emissions from I.C engines considered as a regulated emission but it is a leading contributor towards Greenhouse gases. In this work a numerical investigation on backpressure was carried out by varying porosity factor of activated carbon. Activated Carbon seems to be viable substance to capture CO2 emission from diesel exhaust. To evaluate the backpressure an analysis was carried out using CFD ANSYS fluent software. In the present investigation an analysis is carried out by placing activated carbon at three different variations. Then the analysis are done by varying three different porosity percentages 30,35 and 45 by placing activated carbon at three different locations. Final study reveals that activated carbon placed at PC35-3 layout shows optimum backpressure and high filtration efficiency while compared with other two layouts.

Keywords

Carbon Dioxide, Backpressure, CFD ANSYS, Filtration Efficiency.

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