Informatics Publishing Limited

S. Jain Manu ¹, S. Agrawal Yogesh ², B. Chavhan Randhir ¹, M. Bari Manoj ¹, S. D. Barhate ¹

Affiliations
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner. Dist: Jalgaon. (M.S.)– 424206, IN
2 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, IN

Abstract

Two simple, accurate, reproducible and economical requiring no prior separation procedures for simultaneous estimation of Levosulpiride and Esomeprazole in capsule dosage form have been developed. First method employs formation and solving of simultaneous equation using 234nm and 300nm as analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 241 nm (as an isosbestic point) and 300nm. Levosulpiride and Esomeprazole at their respective max 234nm and 300nm and at isosbestic point 241nm shows linearity in the concentration range of 1-20 μg/mL. The proposed methods are recommended for routine analysis since these are sensitive and reliable.

Keywords

Esomeprazole, Levosulpiride, λmax, Isosbestic Point, Simultaneous Equation, Q Method.

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S. Jain Manu ¹, B. Lohare Ganesh ², M. Bari Manoj ², B. Chavan Randhir ², D. Barhate Shashikant ², B. Shah Chirag ³

Affiliations
1 Shree Suresh Dada Jain Institute of Pharmaceutical Education & Research, Jamner-424 206, Maharashtra, IN
2 Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Dist: Jalgaon (M.S.), IN
3 Watson Laboratories, Ambarnath, IN

Abstract

Spray drying is an interesting manufacturing technique for the pharmaceutical industry since it uses a one-step process for formation and drying of powders. Using this technique the number of unit operations is reduced, improving production efficiency and reducing costs, especially since spray drying is a technique which can be easily automated and equipped for in-line product analysis. In addition, spray drying can be considered a continuous process, thus reducing time-to-market because of scale-up benefits and better quality. Spray drying has a wide range of applications in the pharmaceutical and biotech industry. It is a convenient method to produce (coprocessed) excipients. Spray drying is applied to improve the compactability of drugs and to perform microencapsulation, granulation and complex formation. In addition, spray drying is successfully used for the modification of biopharmaceutical properties and the formulation of dry powder aerosols and heat sensitive materials.

Keywords

Spray Drying, Directly Compressible Powders, Encapsulation, Improved Bioavailability, Dry Powder Aerosol, Heat Sensitive Materials.

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