A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Naidu, S. V.
- The Estimation of Nilotinib in Capsule Dosage Form by RP-HPLC
Authors
1 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy, Hyderabad-500 034, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 4 (2011), Pagination: 100-102Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Nilotinib in capsule dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5m partical size, with mobile phase consisting of 0.02M Dipotassium hydrogen orthophosphate in water pH-2.5 with orthophosphoric acid and Acetonitrile in the ratio of 60:40 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 266 nm. The retention time was 8.508 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y= 81268.215X+174323.3. The limit of detection and limit of quantification was 0.1μg and 0.3μg/ml respectively. The percentage assay of Nilotinib was 99.61%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Nilotinib in bulk drug and in its pharmaceutical dosage form.
Keywords
Nilotinib, RP-HPLC, Estimation, and Capsules.
- The Estimation of Raltigravir in Tablet Dosage Form by RP-HPLC
Authors
1 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy Dist., Hyderabad-500 034, IN
2 Centre for Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Vishakapatnam – 530003, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 3 (2011), Pagination: 56-58Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Raltigravir in tablet dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5m partical size, with mobile phase consisting of 0.02M Dipotasium hydrogen orthophosphate in water pH 2.5 with orthophosphoric acid and Acetonitrile in the ratio of 60:40 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 210 nm. The retention time was 13.310 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y=56490.819X - 302507. The limit of detection and limit of quantification was 0.2μg and 0.6μg/ml respectively. The percentage assay of Raltigravir was 98.86%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Raltigravir in bulk drug and in its pharmaceutical dosage form.
Keywords
Raltigravir, RP-HPLC, Estimation, and Tablets.- The Estimation of Nilotinib in Capsule Dosage Form by RP-HPLC
Authors
1 Centre For Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Vishakapatnam - 530003, IN
2 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy, Hyderabad-500 034, IN
Source
Asian Journal of Pharmacy and Technology, Vol 1, No 3 (2011), Pagination: 82-84Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Nilotinib in capsule dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5m partical size, with mobile phase consisting of 0.02M Dipotassium hydrogen orthophosphate in water pH-2.5 with orthophosphoric acid and Acetonitrile in the ratio of 60:40 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 266 nm. The retention time was 8.508 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y= 81268.215X+174323.3. The limit of detection and limit of quantification was 0.1μg and 0.3μg/ml respectively. The percentage assay of Nilotinib was 99.61%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Nilotinib in bulk drug and in its pharmaceutical dosage form.
Keywords
Nilotinib, RP-HPLC, Estimation, and Capsules.- The Estimation of Darunavir in Tablet Dosage form By RP-HPLC
Authors
1 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy Dist., Hyderabad-500 034, IN
2 Centre for Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Vishakapatnam - 530003, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 3 (2011), Pagination: 74-76Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Darunavir in tablet dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5m partical size, with mobile phase consisting of 0.02M Dipotassium hydrogen orthophosphate +0.02M Potassium Dihydrogen orthophosphatein in water and Acetonitrile in the ratio of 40:60 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 265 nm. The retention time was 5.859 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y= 44076.08X +726603. The limit of detection and limit of quantification was 0.1μg and 0.3μg/ml respectively. The percentage assay of Darunavir was 98.58%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Darunavir in bulk drug and in its pharmaceutical dosage form.
Keywords
Darunavir, RP-HPLC, Estimation, and Tablets.- The Estimation of Maraviroc in Tablet dosage form by RP-HPLC
Authors
1 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy Dist., Hyderabad-500 034, IN
2 Centre for Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Visakhapatnam- 530003, IN
3 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy Dist., Hyderabad-500 034, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 5 (2011), Pagination: 230-232Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Maraviroc in tablet dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5m partical size, with mobile phase consisting of 0.02M Dipotasium hydrogen orthophosphate in water pH 2.5 with orthophosphoric acid and Acetonitrile in the ratio of 60:40 v/v was used. The flow rate was 0.8 ml/min and the effluents were monitored at 210 nm. The retention time was 4.330 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y= 31018.059X + 44222.4. The limit of detection and limit of quantification was 0.2μg and 0.6μg/ml respectively. The percentage assay of Maraviroc was 99.42%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Maraviroc in bulk drug and in its pharmaceutical dosage form.
Keywords
Maraviroc, RP-HPLC, Estimation, and Tablets.- The Estimation of Etravirine in Tablet dosage form by RP-HPLC
Authors
1 Department of Pharmaceutical Chemistry, Omega College of Pharmacy, Edulabad, Ghatkesar, Ranga Reddy, Hyderabad-500 034, IN
2 Centre for Biotechnology, Department of Chemical Engineering, College of Engineering (A), Andhra University, Visakhapatnam- 530003, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1649-1651Abstract
A simple, precise, rapid and accurate reverse phase HPLC method was developed for the estimation of Etravirine in tablet dosage form. A RP Inertsil ODS-3V C-18, 250x4.6 mm, 5μm partical size, with mobile phase consisting of 0.03M Potassium Dihydrogen orthophosphate in water pH-3.2 with orthophosphoric acid and Acetonitrile in the ratio of 30:70 v/v was used. The flow rate was 1.0 ml/min and the effluents were monitored at 309 nm. The retention time was 9.111 min. The detector response was linear in the concentration of 80-240μg/ml. The respective linear regression equation being Y= 58030X + 86395.9 the limit of detection and limit of quantification was 0.1μg and 0.3μg/ml respectively. The percentage assay of Etravirine was 98.46%. The method was validated by determining its accuracy, precision and system suitability.
The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of Etravirine in bulk drug and in its pharmaceutical dosage form.