Informatics Publishing Limited

Lalit Kumar ¹, Ruchi Verma ²

Affiliations
1 Department of Pharmaceutics, Himachal Institute of Pharmacy, Paonta Sahib, Sirmour, Himachal Pradesh-173001, IN
2 Department of Pharmachemistry, Devsthali Vidyapeeth, Rudharpur, Uttrakhand – 263153, IN

Abstract

Purpose of this article is to introduce about the vaginal drug delivery, preparation of intra - vaginal gel and methods used for the evaluation of most effective intra - vaginal gel. Perhaps vagina is less explored, but efficient route for administration of drugs due to the presence of dense blood vessels network. To date, most vaginal drug delivery systems are traditionally used to deliver contraceptives and drugs to treat vaginal infections. However, vaginal drug delivery is not limited to these drugs as the vagina has promise as a site to topically deliver drugs which will be absorbed systemically because of the dense network of blood vessels in the vaginal wall. This is an advantage over other routes of transdermal and trans-mucosal drug delivery. In addition, vaginal drug delivery has an advantage over oral delivery because it avoids the hepato-gastrointestinal first-pass metabolism of drugs. This review article contains classification of gel, mechanism of absorption, and method of preparation and evaluation of intra-vaginal gel is also well explained in this review article.

Keywords

Gel, Vagina, Intra-Vaginal.

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Ruchi Verma ¹, Vinti Nanda ¹

Affiliations
1 Chhatrapati Shivaji Institute of Technology, Durg, CG, IN

Abstract

Public-key cryptography is fast becoming the foundation for online commerce and other applications that require security and authentication in an open network. The widespread use of public-key cryptography requires a public-key infrastructure to publish and manage public-key values. Without a functioning infrastructure, public-key cryptography is only marginally more useful than traditional, secret- key cryptography. This paper presents a set of characteristics that are common to all public-key infrastructures. These criteria are intended to encapsulate the fundamental issues that arise when dealing with such systems. They can be used both as a "shopping list" for those who need to choose an infrastructure for a particular application, and as a guide for infrastructure developers, that they may be more aware of any compromises or tradeoffs they might make in their work. The characteristics are used to present a survey of current and some proposed infrastructure systems. The criteria reveal the strengths and weaknesses of each system, and indicate where improvements may be required. The characteristics presented here are intended to enhance rather than restrict development in the field. This is not necessarily an exhaustive list, and it is the author's intention to revise these criteria as new ideas emerge.

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