Informatics Publishing Limited

Deepak Kumar Saini ¹, Saurabh Garg ¹, Roshan Lal ¹, Rajat Chopra ¹, S. N. Sachdeva ¹

Affiliations
1 Civil Engineering Department, National Institute of Technology, Kurukshetra, IN

Abstract

It is generally believed that increase in subgrade strength leads to decrease in the thickness of a rigid pavement which helps in reducing the cost of pavement. The guidelines of Indian Roads Congress (IRC) for the design of rigid pavements also recommend the use of select soil of minimum CBR 8% in the subgrade for design of cement concrete pavement for roads having traffic greater than 450 CVPD. An attempt has been made in this paper to study the effect of variation in subgrade strength on thickness and cost of a rigid pavement. It is found that the thickness and cost of pavement may not decrease with an increase in the strength of subgrade soil. The provision of using select soil of minimum CBR 8% in the subgrade of the road as recommended by IRC, therefore, needs to be applied carefully.

Keywords

CBR, Cost of Pavement, PQC, Rigid Pavement, Subgrade Strength.

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Roshan Lal ¹, Mahima sharma ¹, Sangita Behera ¹, Raj Kumar Regar ¹, Deepika Tripathi ¹, G V Narasimha Kumar ², Satvinder Singh ¹, Digvijay Verma ³, Pankaj Gupta ¹, Subhash Kaushik ³, Anil Khurana ³

Affiliations
1 Department of Pharmacology, Dr. D. P. Rastogi, Central Council for Research in Homoeopathy, Noida - 201301, Uttar Pradesh, IN
2 Dr Anjali Chatterji Regional Research Institute for Homoeopathy, Kolkata - 700035, West Bengal, IN
3 Central Council for Research in Homoeopathy, New Delhi - 110023, IN

Abstract

Arsenic album is frequently prescribed in homoeopathy for many diseases. However, its safety data is not available. Thus, the study’s purpose is to evaluate the oral toxicity of Arsenic album 6C, 30C, and 200C in rats. Arsenic album (6C, 30C, and 200C) was given at 2000 μl/kg for acute toxicity and observed for up to 14 days. For subacute toxicity, it was given for 28 days and observed for clinical signs, change in body weight and Mortality. Hematological, biochemical, organ weight and histopathological analyses were assessed. Results indicate no mortality of arsenic album in acute toxicity and LD50 is >2000 μl/kg. In the subacute toxicity study, arsenic album (200 μl/kg) did not show any significant changes in above parameters. It may be concluded that the arsenic album (6C, 30C, and 200C) is safe and produces no toxicity when administered orally for a prolonged duration at 200 μl/kg in rats.

Keywords

Complementary and Alternative Medicines, Homoeopathy, Safety, Toxicity.

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