Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Lesmana, Ronny
- A Doubled-Blind, Crossover-RCT in T2DM for Evaluating Hypoglycemic Effect of P. indicus, M. charantia, P. vulgaris and A. paniculata in Central Java
Abstract Views :401 |
PDF Views:126
Authors
Mahalul Azam
1,
Charles Ong Saerang
2,
Sri Ratna Rahayu
1,
Fitri Indrawati
1,
Irwan Budiono
1,
Arulita Ika Fibriana
1,
Muhammad Azinar
1,
Nur Anna C. Sa'dyah
3,
Erwin Budi Cahyono
4,
Ronny Lesmana
5
Affiliations
1 Center for Health and Biomedical Study, Research Institute of UNNES, Department of Public Health, Universitas Negeri Semarang, ID
2 Njonja Meneer Research and Development Laboratory, Semarang, ID
3 Sultan Agung Islamic Hospital, Semarang, ID
4 Department of Internal Medicine, Universitas Islam Sultan Agung, Semarang, ID
5 Division of Physiology, Department of Anatomy, Physiology and Cell Biology, Universitas Padjadjaran, Bandung, ID
1 Center for Health and Biomedical Study, Research Institute of UNNES, Department of Public Health, Universitas Negeri Semarang, ID
2 Njonja Meneer Research and Development Laboratory, Semarang, ID
3 Sultan Agung Islamic Hospital, Semarang, ID
4 Department of Internal Medicine, Universitas Islam Sultan Agung, Semarang, ID
5 Division of Physiology, Department of Anatomy, Physiology and Cell Biology, Universitas Padjadjaran, Bandung, ID
Source
Journal of Natural Remedies, Vol 16, No 3 (2016), Pagination: 108-114Abstract
This study investigated whether mixture extract of Pterocarpus indicus, Momordica charantia, Phaseolus vulgaris and Andrographis paniculata could lower plasma glucose in Type 2 Diabetes Mellitus (T2DM) patients. 43 T2DM patients, consist of 10 male and 33 female patients participated in this possitive-controlled, double-blind, and crossover clinical study with administration of either mixture extract (22 mg/kg BW) or glibenclamide 5 mg daily in breakfast time. Treatment of extract or glibenclamide was administered for a month, then medication was changed after a week of washout period and finally combination therapy was administered after wash out period as well. The efficacy of mixture extracts was measured by using Fasting Plasma Glucose (FPG) and two-hour Postprandial Plasma Glucose (PPG). Forty-one subjects completed the study. Data was analyzed using SPSS 19 with Student's t test, and p<0.05 was considered significant. FPG level significantly decreased 16.07 mg/dl after extract, 43.34 mg/dl after glibenclamide and 50.16 mg/dl after combination treatment. Two-hour PPG level decreased 25.88 mg/dl after extract, 66.61 after glibenclamide and 58.93 after combination treatment. We concluded that extract administration could lower FPG and PPG although not as good as glibenclamide treatment did and combination treatment was the best to lower FPG.Keywords
Anti-Diabetic, Clinical-Trial, Extract, Herbal-Medicine.Full Text
References
- WHO. Global report on diabetes. WHO. 2016; 25–30.
- Depkes RI. Situasi dan Analisis Diabetes di Indonesia. Jakarta: Pusdatin Kemenkes RI; 2014.
- Raman BV, Krishna NV, Rao BN, Saradhi MP, Rao MVB. Plants with antidiabetic activities and tehir medicinal values. Int Res J Pharm. 2012; 3(3):11–5.
- Zohary D, Hopf M. Domestication of plants in the old world: the origin and spread of cultivated plants. Oxford University Press; 2000.
- Bhogireddy N, Naga A, Ramesh B, Pradeep M. Anti-inflammatory and anti-diabetic activities with their other ethnomedicinal properties of the plants. J Med Plants Stud. 2013; 1(5):87–96.
- Soetarno S, Sukandar EY, Yuwono A. Aktivitas hipoglisemik ekstrak herba sambiloto (Andrographis paniculata Nees, Acanthaceae). J Med Plants Stud. 2000; 4(2):62–9.
- Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pacific J Trop Dis. 2013; 3(2):93–102.
- Nugroho AE, Andrie M, Warditiani NK, Siswanto E, Pramono S, Lukitaningsih E. Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian J Pharmacol. 2012 Oct 27; 44(3):377–81.
- Saerang C, Azam M. Preclinical toxicity and efficacy test of P. indicus, M. charantia, P. vulgaris and A. paniculata on lowering blood glucose. PT. Nyonya Meneer-BBPT. 2005.
- Rull JA, Gonzalez-Millan H, Quibrera R, Garcia-Viveros M, Lozano-Castaneda O. Over-all therapeutic usefulness of glybenclamide, a new hypoglycemic sulfonylurea. Diabetes. 1970; 19(4):264–70.
- Okokon JE, Antia BS. Hypoglycaemic and anti-diabetic effect of Setaria megaphylla on normal and alloxan induced diabetic rats. J Nat Remedies. 2007; 7(2):220–4.
- Yulinah E, Sukrasno S, Fitri MA. Aktivitas Antidiabetika Ekstrak Etanol Herba Sambiloto. Jms. 2001; 6(1):13–20.
- Rahman IU. Bitter melon (Momordica charantia) reduces serum sialic acid in type2 diabetics: evidence to delay the process of atherosclerosis. Chin Med. 2011; 02(04):125–9.
- Day C, Cartwright T, Provost J, Bailey CJ. Hypoglycaemic effect of Momordica charantia extracts. Planta Med. 1990; 56(12):426–9.
- Grover JK, Yadav SP. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol. 2004; 93(1):123–32.
- Adesegun SA, Fayemiwo O, Odufuye B, Coker HAB. α-amylase inhibition and antioxidant activity of Pterocarpus osun craib. J Nat Prod. 2013; 6:90–5.
- Mishra A, Srivastava R, Srivastava SP, Gautam S, Tamrakar AK, Maurya R, et al. Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. and analysis of phytoconstituents. Indian J Exp Biol. 2013; 51(5):363–74.
- Hendriati L, Kresnamurti A, Widodo T, Natania E, Yulia M. Efek hipoglikemik dan uji hipersensitivitas sediaan transdermal ekstrak angsana (Pterocarpus indicus Willd). J Farm Sains dan Terap. 2015; 2(2):15–9.
- Sharma RK, Patki PS. Double-blind, placebo-controlled clinical evaluation of an Ayurvedic formulation (GlucoCare capsules) in non-insulin dependent diabetes mellitus. J Ayurveda Integr Med. 2010; 1(1):45–51.
- Luka C, Olatunde A, Tijjani H, Ia O-E. Effect of aqueous extract of Phaseolus vulgaris L. (red kidney beans) on alloxan-induced diabetic wistar rats plant material. Int J Sci Invent Today. 2013; 2(4):292–301.
- Ricin in Castor Bean (Ricinus Communis L.) Seeds: A Review on Its Anticancer Activity and the Role of Cytotoxicity Enhancers
Abstract Views :51 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java,, ID
2 Physiology Molecular Laboratory, Central Laboratory, Universitas Padjadjaran, West Java,, ID
1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java,, ID
2 Physiology Molecular Laboratory, Central Laboratory, Universitas Padjadjaran, West Java,, ID
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 405-408Abstract
Ribosome-inactivating proteins (RIPs) are toxins that are capable to permanently inhibit the synthesis of protein. RIP type II is a heterodimeric protein consisting of an A subunit linked to a lectin-like B chain by a disulfide bridge. Ricin contained in the seeds of Ricinus communis L. is a type II RIP which possesses cytotoxicity activity. However, due to the non-selectivity of the B-lectin chain, ricin needs delivering-vehicles to enhance its cytotoxicity. This article is devoted to reviewing the anticancer activity of ricin in castor bean seeds (a plant type II RIPs) and its various types of cytotoxicity enhancers.Keywords
apoptosis, autophagy, lectin, Ribosome-inactivating protein.
References
- Virgilio M, Lombardi A, Caliandro R, Fabbrini MS. Ribosome-inactivating proteins: From plant defense to tumor attack. Toxins. 2010; 2: 2699-2737.
- Zhou Y, Li XP, Kahn JN, Tumer NE. Functional assays for measuring the catalytic activity of ribosome-inactivating proteins. Toxins. 2018; 10(6): 240.
- Zhu F, Zhou YK, Ji ZL, Chen XR. The plant ribosome-inactivating proteins play important roles in defense against pathogens and insect pest attacks. Frontiers in Plant Sciences. 2018; 9:146.
- Sharma N, Park SW, Vepachedu R, Barbieri L, Ciani M, Stirpe F, Savary BJ, Vivanco JM. Isolation and characterization of an RIP (ribosome-inactivating protein)-like protein from tobacco with dual enzymatic activity. Plant Physiology. 2004; 134: 171-181.
- Sampada S. Sawant, Vishal R. Randive, Savita R. Kulkarni. Lectins from seeds of Abrus precatorius: Evaluation of Antidiabetic and Antihyperlipidemic Potential in Diabetic Rats. Asian J. Pharm. Res. 2017; 7(2):71-80.
- Grela P, Szajwaj M, Horbowicz-Drożdżal P, Tchórzewski M. How ricin damages the ribosome. Toxins. 2019; 11(5): 241.
- Hendrix DK, Brenner SE, Holbrook SR. RNA structural motifs: building blocks of a modular biomolecule. Quarterly Reviews of Biophysics. 2005; 38(3): 221–243.
- Shi X, Khade PK, Sanbonmatsu KY, Joseph S. Functional role of the sarcin–ricin loop of the 23S rRNA in the elongation cycle of protein synthesis. Journal of Molecular Biology. 2012; 419(3-4): 125-138.
- Voorhees RM, Schmeing TM, Kelley AC, Ramakrishnan V. The mechanism for activation of GTP hydrolysis on the ribosome. Science. 2010; 330: 835.
- Szewczak AA, Moore PB, Chang YL, Wool IG. The conformation of the sarcin/ricin loop from 28S ribosomal RNA. Proceedings of the National Academy of Sciences of the USA. 1993; 90: 9581-9585.
- Walsh MJ, Dodd JE, Hautbergue GM. Ribosome-inactivating proteins. Potent poisons and molecular tools. Virulence. 2013; 4(8): 774–784.
- Jena J , Gupta AK. Ricinus communis a phytopharmacological review, International Journal of Pharmacy Pharmaceutical Sciences 2012; 4(4): 25-29.
- Rutenber E, Katzin BJ, Ernst S, Collins EJ, Misna D, Ready MP, Robertus JD. Crystallographic refinement of ricin to 2.5 A. Proteins. 1991. 10: 240-250.
- Li XP, Kahn PC, Kahn JN, Grela P, Tumer NE. Arginine residues on the opposite side of the active site stimulate the catalysis of ribosome depurination by ricin A chain by interacting with the P-protein stalk. The Journal of Biological Chemistry. 2013; 288(42):30270-30284.
- Chandrasekar. R, Sivagami. B, M. Niranjan Babu. A Pharmacoeconomic Focus on Medicinal Plants with Anticancer Activity. Res. J. Pharmacognosy and Phytochem. 2018; 10(1): 91-100.
- Krishnasamy L, Selvam MM, Ravikrishnan B. Anticancer property of Colchicine isolated from Indigofera aspalathoids. Research J. Pharm. and Tech. 2016; 9(4): 386-390.
- Merlin NJ, Parthasarathy V, Manavalan R, Devi P, Meera R. Apoptosis Significance and Molecular Mechanisms- A Review. Asian J. Research Chem. 2009. 2(4): 369-375.
- Mukesh KN, Satish P, Rajnikant P, Shikha S, Sanjay JD, Manju RS, Deependra S. Lung Cancer Targeting: A Review. Research J. Pharm. and Tech. 2013. 6(11): 1302-1306.
- Manoj SP, Hardik J, Leena P, Vilasrao JK. Human Milk: Excellent Anticancer Alternative. Research J. Pharm. and Tech. 2012. 5(1): 14-19.
- Namrata D, Bhavna D, Skand M, Yogeshwer S. Lupeol Induced Apoptosis in Human Lung Cancer Cell Line: A Flow Cytometry Study. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(4): 197-203
- Epy ML, Widjiati, Maslichah M, Bambang PSR, Eka PH. Crosstalk between Necrosis and Apoptosis of Embryonal Cerebral Cortex Neuron Mice (Mus musculus) Caused by Carbofuran Exposure. Research J. Pharm. and Tech. 2019; 12(11): 5492-5498.
- Diksha, SP. Role of Stem Cells in treatment of different Diseases. Research J. Pharm. and Tech 2018; 11(8): 3667-3678.
- Hendrian DS, Susy F, Paulus S, Bambang P, Ugroseno YB, Endang RK. Detection of the Calcium and ATP Role in Apoptosis of Retinoblastoma Culture Cells through Caspase-3 Expression. Research J. Pharm. and Tech. 2019; 12(3): 1307-1314.
- Amanjot K, Mahendra PS. A Mini Review on Environmental Contaminant induced Programmed cell Death in Fruit Fly. Research J. Pharm. and Tech. 2019; 12(12): 6174-6180.
- Rao PV, Jayaraj R, Bhaskar AS, Kumar O, Bhattacharya R, Saxena P, Dash PK, Vijayaraghavan R. Mechanism of ricin-induced apoptosis in human cervical cancer cells. Biochemical Pharmacology 2005; 69(5): 855-865.
- Jetzt AE, Cheng J, Nilgun E, Tumer NE, Cohick WS. Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells. The International Journal of Biochemistry and Cell Biology. 2009; 41(12): 2503–2510.
- Bharadwaj S, Rathore SS, Ghosh PC. Enhancement of the cytotoxicity of liposomal ricin by the carboxylic ionophore monensin and the lysosomotropic amine NH4Cl in Chinese hamster ovary cells. International Journal of Toxicology. 2006; 25(5):349-59.
- Nguyen LTB, Ngo NT, Nguyen TLN, Nguyen DT. Anticancer Activities of Ricin-Liposome Complexes on SKMEL-28 Cells. Asian Pacific Journal of Cancer Prevention. 2019; 20(7): 2117–2123.
- Tyagi N, Rathore SS, Ghosh PC. Efficacy of Liposomal Monensin on the Enhancement of the Antitumour Activity of Liposomal Ricin in Human Epidermoid Carcinoma (KB) Cells. Indian Journal of Pharmaceutical Sciences 2013; 75(1): 16–22.
- Tyagi N, Rathore SS, Ghosh PC. Enhanced killing of human epidermoid carcinoma (KB) cells by treatment with ricin encapsulated into sterically stabilized liposomes in combination with monensin. Drug Delivery. 2011; 18(6): 394-404.
- Tyagi N, Ghosh PC. Folate receptor mediated targeted delivery of ricin entrapped into sterically stabilized liposomes to human epidermoid carcinoma (KB) cells: effect of monensin intercalated into folate-tagged liposomes. European Journal of Pharmaceutical Sciences. 2011; 43(4): 343-353.
- Li C, Yan R, Yang Z, Wang H, Zhang R, Chen H, Wang J. BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor. Oncotarget. 2017; 8(28): 46704–46705.