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Bathe, Ritesh
- An Updated Review on Formulation and Evaluation of Microsponge
Abstract Views :445 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 6, No 2 (2015), Pagination: 77-85Abstract
Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. Microsponge and Nanosponge delivery System was originally developed for topical delivery of drugs can also be used for controlled oral delivery of drugs using water soluble and bioerodible polymers. Microsponge delivery system (MDS) can entrap wide range of drugs and then release them onto the skin over a time by difussion mechanism to the skin. It is a unique technology for the controlled release of topical agents and consists of nano or micro porous beads loaded with active agent and also use for oral delivery of drugs using bioerodible polymers.Keywords
Microsponges, Controlled Release, Porous Microspheres, Nanosponge, Solvent Diffusion Method, Quasi-Emulsion Method.
- Zero order and Area Under Curve Spectrophotometric Methods for Determination of Riboflavin in Pharmaceutical Formulation
Abstract Views :332 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 35-40Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Riboflavin in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 445 nm and the area under the curve method values measured at 420-473nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Riboflavin using 5-25μg/ml (r²=0.999 and r²=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Riboflavin in tablets.Keywords
Riboflavin, UV Visible Spectrophotometry, AUC, Method Validation, Zero Order Method.- Simultaneous UV Spectrophotometric Methods for Estimation of Cefixime Trihydrate and Ofloxacin in Bulk and Tablet Dosage Form
Abstract Views :273 |
PDF Views:0
Authors
Audumbar Mali
1,
Santosh Jadhav
1,
Rahul Gorad
2,
Aamer Quazi
2,
Ritesh Bathe
1,
Manojkumar Patil
1,
Ashpak Tamboli
3
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 2 (2016), Pagination: 100-106Abstract
Simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Cefixime Trihydrate and Ofloxacin in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 287 nm and 296 nm for Cefixime Trihydrate and Ofloxacin respectively. Method B is area under curve (AUC), in the wavelength range of 265-301 nm for Cefixime Trihydrate and277-320nm for Ofloxacin. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Cefixime Trihydrate and 5-25 μg/ml for Ofloxacin. The accuracy of the methods was assessed by recovery studies and was found to be 98.83% and 100.12% for Cefixime Trihydrate and 102.71 % and 99.01 % Ofloxacin by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Cefixime Trihydrate and Ofloxacin in commercial pharmaceutical dosage form.Keywords
Cefixime Trihydrate, Ofloxacin, Simultaneous Estimation, Accuracy, Absorbance Maxima Method, Area under Curve.- Simultaneous UV Spectrophotometric Methods for Estimation of Ranitidine and Domperidonein Bulk and Tablet Dosage Form
Abstract Views :258 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute College of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Raigad-410206, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute College of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Raigad-410206, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 5-10Abstract
Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Ranitidine and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 314 nm and 286 nm for Ranitidine and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 269-340nm for Ranitidine and 262-307nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25μg/ml for Ranitidine and 5-25 μg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 99.18% and 100.21% for Ranitidine and 100.19% and 101.57% Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Ranitidine and Domperidone in commercial pharmaceutical dosage form.Keywords
Ranitidine, Domperidone, Simultaneous Estimation, Precision, Absorbance Maxima Method, Area under Curve.- Simultaneous UV Spectrophotometric Methods for Estimation of Carvedilol and Hydrochlorothiazide in Bulk and Tablet Dosage Form
Abstract Views :311 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Dist. Latur-413512 Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Dist. Latur-413512 Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 15-20Abstract
Two simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Carvediloland Hydrochlorothiazide in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 290 nm and 271 nm for Carvedilol and Hydrochlorothiazide respectively. Method B is area under curve (AUC), in the wavelength range of 260-308 nm for Carvedilol and 2246-292 nm for Hydrochlorothiazide. Linearity for detector response was observed in the concentration range of 5-25μg/ml for Carvedilol and 5-25 μg/ml for Hydrochlorothiazide. The accuracy of the methods was assessed by recovery studies and was found to be 100.13% and 102.28% for Carvedilol and 99.04% and 99.89% Hydrochlorothiazide by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Carvedilol and Hydrochlorothiazide in commercial pharmaceutical dosage form.Keywords
Carvedilol, Hydrochlorothiazide, Simultaneous Estimation, Accuracy, Absorbance Maxima Method, Area under Curve.- Zero Order and Area under Curve Spectrophotometric Methods for Determination of Domperidone in Pharmaceutical Formulation
Abstract Views :283 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 3 (2015), Pagination: 182-187Abstract
Simple, fast and reliable spectrophotometry methods were developed for determination of Domperidonein bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 286nm and the area under the curve method values measured at 279-293 nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Domperidone using 5-25μg/ml (r2=0.999 and r2=0.998) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Domperidonein tablets.Keywords
Domperidone, UV Visible Spectrophotometry, AUC, Method Validation, Precission, Accuracy.- Development and Estimation of Pyridoxine HCl in Bulk and Formulation by Second Order Derivative Area under Curve UV-Spectrophotometric Methods
Abstract Views :267 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 106-112Abstract
Simple, novel, fast, accurate and reliable spectrophotometric methods were developed for determination of Pyridoxine HCl in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Dist. water. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 301-319nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Pyridoxine HCl using 5-25μg/ml (r²=0.9966) for second order derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Pyridoxine HCl in pharmaceutical formulations.Keywords
Pyridoxine HCI, Second Order Derivative, Area under Curve (AUC), Precision, Accuracy.- Simultaneous UV Spectrophotometric Methods for Estimation of Paracetamol and Domperidone in Bulk and Tablet Dosage Form
Abstract Views :284 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 1 (2016), Pagination: 21-26Abstract
Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Paracetamol and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 248 nm and 286 nm for Paracetamol and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 220-274 nm for Paracetamol and 262-304 nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Paracetamol and 5-25 μg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 100.11 % and 102.04 % for Paracetamol and 99.10 % and 100.52 % Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Paracetamol and Domperidone in commercial pharmaceutical dosage form.Keywords
Paracetamol, Domperidone, Simultaneous Estimation, Area under Curve, Precision, Absorbance Maxima Method.- An Updated Review on Current Situation of Corona Virus Disease
Abstract Views :150 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 167-175Abstract
COVID-19 is currently regarded as a lethal disease. COVID-19 has exaggerated over 2.5 million citizen’s universal, consequential into more than 170,000 confirmed cases deaths Very recently a novel corona virus, SARS-CoV-2, was identified because of causal cause of an outbreak of viral pneumonia centered around Wuhan, Hubei, China in Dec 2019, now called as COVID-19. The corona disease infection 2019 (Covid-19) (2019- nCoV) pandemic is an international public health emergency with major social and economic disruptions and devastating health consequences. COVID-19 is also known as a pandemic. COVID-19 has infected over 2.5 million people around the world, resulting in over 170,000 deaths. The rapid development of vaccines is imperative. Corona viruses are a group of related RNA viruses that cause diseases in mammals and birds. It triggers breathing zones that can vary from moderate to fatal in humans and birds more than a few issues to ordinary frosty (so as to can also be affected via different pathogens, mostly rhinoviruses) are mild, while more deadly strains be able to reason SARS, MERS, and COVID-19 in humans. Thousands of illnesses and deaths have occurred as a result of the disease. In fact, none exact cure remains available for the disorder yet this demands that even the condition should not expand. Notable Isolation of sick people, adequate ventilation, hand washing, and the utilization of PPE Kit are also preventive measures. As a result, this paper covers all aspects of COVID-19, including epidemiology, transmission, clinical characteristics, diagnosis, treatment, and prevention.
Keywords
Covid-19, SARS, Pandemic, MERS, Corona Virus, Viral PneumoniaReferences
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