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Yamgar, Ramesh
- Dealing With the Challenges During Large Scale Manufacturing of Polymorphic Drug Substances
Abstract Views :212 |
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Authors
Affiliations
1 P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
1 P. G. Dept of Chemistry, Govt. of Maharashtra’s Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 1, No 3 (2011), Pagination: 63-68Abstract
This paper will discuss the various risks and challenges that manufacturers face regarding the manufacturing of polymorphically pure products especially APIs and detailed specific risks during manufacturing in commercial plants and precautions to be taken during manufacturing, quality inspections and also during their product development efforts in R and D. A conscious approach of all personnel involved in manufacturing teams towards ensuring the polymorphic purity of the drug substance is very much essential element for regulated markets and for business continuity of a generic firm.Keywords
Polymorphs, Drug Substance, Bioavailability, Bioequivalence, Dissolution, Recrystallisation, XRPD, Manufacturing, Regulatory Agencies, DMF, ANDA.- Kinetics of Oxidation of 2-Hydroxy-1-Naphthalidene Anil and Substituted Anils by Ce4+ → Ce3+ Redox System in Aqueous Sulphuric Acid Medium
Abstract Views :192 |
PDF Views:0
Authors
Affiliations
1 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062, IN
2 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062
3 Department of Chemistry, Willingdon College, Sangli, Maharashtra, IN
1 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062, IN
2 Chemistry Research Laboratory, Patkar College, Goregaon (W), Mumbai 400 062
3 Department of Chemistry, Willingdon College, Sangli, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1861-1863Abstract
The kinetics of oxidation of the Schiff base 2-hydroxy - 1 - Naphthalidene anil and substituted anils such as 2' - methoxy - 2 - hydroxy - 1 - naphthalidene anil, 3' - Methoxy - 2 - Hydroxy - 1 - Naphthalidene anil and 4' - Methoxy - 2 - Hydroxy - 1- Naphthalidene anil by Ce (IV) as oxidant in aqueous sulphuric acid medium. The kinetic study is carried out by using various concentrations of oxidants and the substrates, which is found to be the first order reaction. A suitable plaussible mechanism has been suggested on the basis of kinetic results.Keywords
Kinetics of Oxidation, Schiff Base, Redox System, Reaction Mechanism.- Transition Metal Tetrahydro-Salophen Type Complexes:Synthesis, Characterization and Antitubercular Studies
Abstract Views :221 |
PDF Views:2
Authors
Affiliations
1 P.G. and Research Laboratory, Department of Chemistry, Government of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East) Mumbai-400 060, IN
2 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon,(West), Mumbai 400 062, IN
1 P.G. and Research Laboratory, Department of Chemistry, Government of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East) Mumbai-400 060, IN
2 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon,(West), Mumbai 400 062, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 9 (2016), Pagination: 425-434Abstract
A series of tetrahydrosalophen Schiff bases have been prepared from the reaction of two equivalents of salicylaldehyde with one equivalent o-phenylenediamine derivatives followed by reduction with NaBH4. The Co (II), Ni (II), Cu (II) and Zn (II) complexes of these ligands have been prepared. All the synthesized ligands and metal complexes were characterized by IR, 1H and 13C-NMR, MS, XRD, TGA, UV-Visible, Fluorescence and elemental analysis. The Preliminary results of antituberculosis study showed that the salophen schiff bases 2a-2b demonstrated very good antituberculosis activity while the tetrahydrosalophen schiff bases 3a-3i showed moderate activity. Among the tested metal complexes 4a was found to be most active with minimum inhibitory concentration (MIC) of 6.25 μg/ml against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294.Keywords
Salophen, Schiff Base, Metal Complex, Antituberculosis, Fluorescence.- Synthesis, SAR, Molecular Docking and Anti-TB Study of 3-Hydroxy-1- Benzofuran-2-Carbohydrazide
Abstract Views :204 |
PDF Views:2
Authors
Bapu R. Thorat
1,
Bhusan Nazirkar
1,
Vaishali B. Thorat
2,
Kishor More
2,
Ravindra Jagtap
3,
Ramesh Yamgar
4
Affiliations
1 P. G. Dept of Chemistry, Govt. of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
2 IES, Junior College, Bandra (E), Mumbai, IN
3 JJT University, Rajasthan, IN
4 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon (W),Mumbai 400 062, IN
1 P. G. Dept of Chemistry, Govt. of Maharashtra, Ismail Yusuf College of Arts, Science and Commerce, Jogeshwari (East), Mumbai 400 060, IN
2 IES, Junior College, Bandra (E), Mumbai, IN
3 JJT University, Rajasthan, IN
4 Department of Chemistry, Chikitsak Samuha’s Patkar-Varde College of Arts, Science and Commerce, Goregaon (W),Mumbai 400 062, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 3 (2016), Pagination: 116-126Abstract
The 3-hydroxy-1-benzofuran-2-carbohydrazide was synthesized from 2-hydroxyacetophenone. To deduce the antibacterial and anticancer activity of the 3-hydroxy-1-benzofuran-2-carbohydrazide, it is docked with different biomarkers of cancer cell and bacteria. Grid was generated for each oncoproteins by specifying the active site amino acids. The binding model of best scoring analogue with each protein was assessed from their G-scores and disclosed by docking analysis using the XP visualizer tool. An analysis of the receptor-ligand interaction studies revealed that 3-hydroxy-1-benzofuran-2-carbohydrazide is most active against 3FDN (threonine protein kinase 6) and 3LAU (Arora 2 kinase) biomarkers and have the features to prove themselves as anti-tuberculosis drugs. The Cramer rules of toxicity predicts the toxicological hazard (when administered orally) from the molecular structure. It shows that it is class III toxic compound. The anti-TB studies show that it shows strong activity (1.6 μg/ml) against mycobacterium tuberculosis (H37 RV strain).Keywords
Benzofurans, Molecular Docking, SAR Study, 3LAU, Hydrazones, TB-Activity.- An Efficient Synthesis of Rabeprazole Sodium
Abstract Views :174 |
PDF Views:1
Authors
Affiliations
1 Chemistry Research Laboratory, Patkar Varde College, Goregaon (West), Mumbai-400062, IN
1 Chemistry Research Laboratory, Patkar Varde College, Goregaon (West), Mumbai-400062, IN