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K. V. M. Krishna ¹, Kshema Hasanthi ¹, Sanjana Joshi ², Ramesh Alluri ³

Affiliations
1 Vishnu Institute of Pharmaceutical Education and Research College, Narsapur, Medak, IN
2 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research College, Narsapur, Medak, IN
3 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research College, Narsapur, Medak, IN

Abstract

Ayurveda is a natural health care system that aims to achieve good health and well-being through a comprehensive approach that addresses mind, body, behavior and environment. The good health is achieved through practicing preventive and personalized medicine. The busy schedule in the lifestyle of this era leads to the total imbalance of doshas in our body. Hence it is important to have a systematic approach to balance the doshas according to seasonal changes. The person-centered theme of Ayurveda mainly concerns maintenance of an abiding health, preventing and treating diseases by doing Panchakarma in Swastha, roga anusaara Panchakarma and Panchakarma for rasayanaadi asadhaarana guna prapthi.

Keywords

Panchakarma, Swastha, Ritu.

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Vanitha Kondi ¹, Ramesh Alluri ¹

Affiliations
1 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak (DT), Telangana – 502313, IN

Abstract

The concept in the development of controlled oral release floating dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. Prazosin hydrochloride is a selective α-1-adrenergic receptor antagonist used to treat hypertension. It has a mean plasma half -life of 2-3 hour.Prazosin has a shorthalflife and low bioavailability in the upper part of the GIT hence it is suitable for gastro-retentive system. In the present study, an antihypertensive drug, Prazosin hydrochloride, is delivered through a gastroretentive microparticulate system capable of floating on simulated gastric fluid for 24 h. Microspheres are prepared by solvent evaporation technique. Microspheres showed excellent buoyancy and a controlled release pattern with 24h. Showed 99.87% drug release at the end of 24 hours. In vivo bioavailability studies performed on albino rats and Tmax, Cmax, AUC and Kel were calculated and confirmed significant improvement in bioavailability. The data obtained thus suggests that floating microspheres can be successfully designed to give controlled drug delivery, improved oral bioavailability.

Keywords

Floating Microspheres, Prazosin, In Vivo Studies, Bioavilability Studies, Pharmacokinetic Parameters.

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M. Venkataswamy ¹, B. Arul ², A. Keerthi Sagar ¹, S. Dinesh Mohan ¹, K. Vanitha ¹, Ramesh Alluri ³

Affiliations
1 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education And Research, Vishnupur, Narsapur, Medak, Telangana, IN
2 Department of Pharmaceutics, Vinayaka Mission’s College of pharmacy Vishnupur, salem, Tamilnadu, IN
3 Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, IN
4 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, IN

Abstract

Mucoadhesive drug delivery systems exploit the attraction between the mucus and polymeric drug carriers. They provide localization of the carriers within the specific body site and prolonged residence time of delivery devices. In this present work an attempt was made to isolate a mucoadhesive polymer from an indigenous plant Annona squamosa Linn and characterize its mucoadhesive properties. The results of the present investigation revealed that the prepared polymer characterized as a mucoadhesive polymer as compared with the available polymers. It shows best results in evaluation processes by shear stress, tensile strength, shear strength, falling sphere, swelling factor, viscosity, stability studies.

Keywords

Preparation of a Mucoadhesive Polymer, Preparation of a Mucoadhesive Polymer from the Extract of Seeds, Annona squamosa Linn., Seeds of Annona squamosa Linn., Polymer from the Extract of Seeds of Annona squamosa Linn., Extract of Seeds of Annona squamosa Linn., Mucoadhesive Polymer, Mucoadhesive Polymer from the Extract.

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