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Co-Authors
- Priti Tiwari
- Neha Rahuja
- Rajesh Kumar
- Vijay Lakshmi
- Mahendra Nath Srivastava
- Suresh Chandra Agarwal
- Arvind Kumar Srivastava
- Poonam Shukla
- Mavurapu Satyanarayana
- Prem C. Verma
- Jaya Tiwari
- Atma P. Dwivedi
- Rohit Srivastava
- Neha Rehuja
- Swayam P. Srivastava
- Sudeep Gautam
- Akhilesh K. Tamrakar
- Anil K. Dwivedi
- Hari N. Kushwaha
- Nagsen Gautam
- Shio K. Singh
- Mukesh Srivastava
- Chandishwar Nath
- Arvind K. Srivastava
- Ram Pratap
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Raghubir, Ram
- Search for Antihyperglycemic Activity in few Marine Flora and Fauna
Abstract Views :538 |
PDF Views:134
Authors
Priti Tiwari
1,
Neha Rahuja
1,
Rajesh Kumar
2,
Vijay Lakshmi
2,
Mahendra Nath Srivastava
3,
Suresh Chandra Agarwal
3,
Ram Raghubir
4,
Arvind Kumar Srivastava
1
Affiliations
1 Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, IN
2 Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, IN
3 Botany, Central Drug Research Institute, Lucknow-226001, IN
4 Pharmacology, Central Drug Research Institute, Lucknow-226001, IN
1 Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, IN
2 Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, IN
3 Botany, Central Drug Research Institute, Lucknow-226001, IN
4 Pharmacology, Central Drug Research Institute, Lucknow-226001, IN
Source
Indian Journal of Science and Technology, Vol 1, No 5 (2008), Pagination: 1-5Abstract
Evaluation and identification of some new natural molecules with antidiabetic property have become one of the major preludes of present day diabetic research. Although few marine natural products are currently in the market or in the clinical trials, marine organisms still remains the greatest unexploited source of potential pharmaceuticals. Because of the unusual diversity of chemical structures isolated from marine organisms, there is intense interest in screening marine natural products for their biomedical potential. Over 300 marine organisms including flora and fauna were collected at the Institute and extracted with methanol. Their extracts were evaluated for blood glucose lowering effect. The present study reports activity profile of 30marine flora/fauna evaluated in sucrose loaded rat model. Among the marine flora , extracts of Dolichandrone, Amoora cuculata, Chaetomorpha torta, Lumnitzera racemosa, Barringtonia racemosa and Excoecaria agallocha Microciona aceratoobtusa and mollusc Scapharca inaequivalvis at 250 mg/kg body weight dose showed slight but insignificant lowering in the blood glucose post sucrose load in normal rats, whereas, the extract of Cynometra ramiflora showed significant inhibition at the same dose . Among the marine fauna the extracts of soft coral Lobophytum pauciflorum, Sarcophyton glaucum and the extracts of sponge Sigmadocia pumila, showed a little but insignificant lowering in blood glucose post sucrose load in normal rats at 250 mg/kg body weight dose.Keywords
Antihyperglycaemic Activity, Marine Flora, Marine Fauna, Oral Glucose Tolerance TestFull Text
References
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- Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent
Abstract Views :293 |
PDF Views:82
Authors
Poonam Shukla
1,
Mavurapu Satyanarayana
1,
Prem C. Verma
1,
Jaya Tiwari
1,
Atma P. Dwivedi
1,
Rohit Srivastava
2,
Neha Rehuja
2,
Swayam P. Srivastava
2,
Sudeep Gautam
2,
Akhilesh K. Tamrakar
2,
Anil K. Dwivedi
3,
Hari N. Kushwaha
4,
Nagsen Gautam
4,
Shio K. Singh
4,
Mukesh Srivastava
5,
Chandishwar Nath
6,
Ram Raghubir
7,
Arvind K. Srivastava
2,
Ram Pratap
8
Affiliations
1 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
2 Division of Biochemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
3 Division of Pharmaceutics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
4 Division of Pharmacokinetics and Pharmaco-Dynamics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
5 Division of Biometry and Statistics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
6 Division of Toxicology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
7 Division of Pharmacology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
8 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031
1 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
2 Division of Biochemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
3 Division of Pharmaceutics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
4 Division of Pharmacokinetics and Pharmaco-Dynamics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
5 Division of Biometry and Statistics, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
6 Division of Toxicology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
7 Division of Pharmacology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, IN
8 Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031
Source
Current Science, Vol 112, No 08 (2017), Pagination: 1675-1689Abstract
The hybrid congener 3 derived from hydroxychalcone and pharmacophore oxypropanolamine for adrenergic receptor, along with its enantiomers 9a and 9b were selected from a series of compounds for detailed studies of their antidiabetic profile in sucrose-challenged, low-dosed, streptozotocin-induced diabetic rats and in db/db mice, and antidyslipidaemic profile in high fat diet-induced dyslipidaemic hamsters. The test compounds exhibited significant and consistent antidiabetic and antidyslipidaemic activities in the above models. The pharmacodynamic studies of two metabolites, 10 and 11, were undertaken. Metabolite 10 having greater bioavailability in plasma was synthesized and found to exhibit significant antidiabetic activity. The parent compound together with its active metabolites exhibited significant oral bioavailability, thus establishing compound 3 as a potential lead molecule for further studies.Keywords
Antidiabetic and Antidyslipidaemic Activity, Chalcone, Diabetes Mellitus, Metabolites, Rodents.Full Text
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