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Rele, Rajan V.
- Simultaneous UV-Spectrophotometric Estimation of Acetaminophen and Guaiphenesin by Second Order Derivative Method in Combined Pharmaceutical Dosage form
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1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 4 (2016), Pagination: 177-181Abstract
The objective of the study was to develop a simple, accurate, precise and rapid a UV spectrophotometric i.e. Second order derivative method for the determination of acetaminophen and guaiphenesin in combined dosage form i.e. tablets by using methanol as a solvent. The method was further validated by ICH guidelines. The proposed second order derivative method involves the measurement of absorbance of one drug at zero crossing point of other; hence wavelengths 215 nm and 234 nm were selected for the estimation of acetaminophen and guaiphenesin respectively. The linearity of the proposed method was found in the concentration range of 1 to 10 μg /ml (r2= 0.9993) for acetaminophen and 5 to 100 μg /ml (r2= 0.9998) for guaiphenesin respectively. The percentage mean recovery was found to be 99.945 % for acetaminophen and 99.955 % for guaiphenesin respectively. The method was also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this method.Keywords
UV spectrophotometric Estimation, Second Order Derivative Method, Acetaminophen, Guaiphenesin Methanol.
- Spectrophotometric Estimation of Paliperidone in Bulk Drug and Pharmaceutical Dosage Form by Area Under Curve Method
Abstract Views :267 |
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Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai-400016, IN
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai-400016, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 31-34Abstract
A simple and precise UV- spectrophotometric method, area under curve [AUC], has been developed and validated for the estimation of paliperidone in bulk drug and its pharmaceutical formulation. Paliperidone was estimated by area under curve (AUC) method for the zero order spectrums in between 234 nm to 242 nm. Beer's law was obeyed in the concentration range of 1 to 14 μg / ml with coefficient of correlation value 0.9996. This method was tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation, which was within the range of 0.1460 % to 0.4589 % for the above method. The proposed method was successfully applied for the determination of paliperidone in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed method is simple, easy to apply, low-cost and require relatively inexpensive instruments.Keywords
Paliperidone, Area Under Curve Method.- UV-Spectrophotometric Estimation of Paliperidone by Derivative Method in Pharmaceutical Dosage Form
Abstract Views :279 |
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Authors
Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 2 (2017), Pagination: 396-400Abstract
The objective of the study was to develop a simple, accurate, precise and rapid a UV spectrophotometric i.e. second and third order derivative methods for the determination of paliperidone in pharmaceutical dosage form by using 0.1 N hydrochloric acid as a solvent. The method was further validated by ICH guidelines. The proposed derivative methods involve the measurement of absorbance at 252 nm for second order and 248.5 nm for third derivative for the estimation of paliperidone respectively. The linearity of the proposed method was found in the concentration range of 1 to 12 μg /ml (r2= 0.9995) for second order derivative and 1 to 12 μg /ml (r2= 0.9999) for third order derivative methods respectively. The percentage mean recovery was found to be 101.3117 % for second order derivative and 99.428 % for third order derivatives methods respectively. The methods were also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this methods.Keywords
UV Spectrophotometric Estimation, Derivative Method, Paliperidone.- Derivative Spectrophotometric Estimation of Amoxicillin Trihydrate and Carbocisteine by Third Order Derivative Spectroscopy Method in Combined Dosage Form
Abstract Views :298 |
PDF Views:1
Authors
Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai-400016, IN
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai-400016, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 6 (2017), Pagination: 1758-1761Abstract
In the proposed method UV spectrophotometric, third order derivative method was developed for validation of amoxicillin tri-hydrate and carbocisteine from pharmaceutical formulation. The ICH guidelines were used for validation of amoxicillin and carbocisteine. The derivative method involves the measurement of absorbance, hence wavelengths 236.2 nm and 210 nm were found to be suitable for the estimation of amoxicillin and carbocisteine respectively. The linearity was found in the concentration range of 10 to 100 μg/ml for amoxicillin and 1 to 10 μg/ml for carbocisteine respectively. For amoxicillin the percentage mean recovery was found to be 100.075% and for carbocisteine was 100.031% respectively. The linearity, accuracy and precision of method was validated by statistically. The less percentage (%) RSD values indicates both intra and inter day have high grade of precision.Keywords
Third Order Derivative UV Spectrophotometric Estimation, Amoxicillin Trihydrate, Carbocisteine.- UV Derivative Spectrophotometric Methods for Validation of Esomeprazole Magnesium Tri-Hydrate in Bulk and Pharmaceutical Dosage Form
Abstract Views :302 |
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Authors
Affiliations
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
1 Central Research Laboratory, D.G. Ruparel College, Matunga, Mumbai 400016, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 135-138Abstract
The objective of the study was to develop simple, accurate, precise and rapid UV first and second order derivative spectrophotometric methods with subsequent validation by using ICH guidelines for the determination of Esomeprazole magnesium tri-hydrate in pharmaceutical dosage form. The proposed first and second order derivative methods involve the measurement of absorbance of drug at 293 nm and 281 nm for the estimation of Esomeprazole magnesium tri-hydrate respectively. The linearity of the proposed methods were found in the concentration range of 4-40 μg /ml (r2= 0.9999) for first order and second order derivative methods and the percentage mean recovery was found to be 99.59 % to 100.69 % respectively. The methods were also statistically validated for its linearity, accuracy and precision. Both intra and inter day variation showed less percentage (%) RSD values indicating high grade of precision of these methods.Keywords
UV Derivative Spectrophotometric Estimation, Esomeprazole Magnesium Tri-Hydrate, Validation.References
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- UV Spectrophotometric Estimation of Secnidazole by Zero Order and Area Under Curve Methods in Bulk and Pharmaceutical Dosage Form
Abstract Views :232 |
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Authors
Affiliations
1 Central Research Laboratory, D. G. Ruparel College, Matunga, Mumbai 400016, IN
1 Central Research Laboratory, D. G. Ruparel College, Matunga, Mumbai 400016, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1753-1756Abstract
Simple and precise UV spectrophotometric methods by UV spectroscopy and area under curve [AUC]-in zero order derivative spectrum have been developed and validated for the estimation of secnidazole in pharmaceutical formulation. The standard and sample solutions of secnidazole were prepared in distilled water. Secnidazole was estimated at 320 nm for the UV-spectrophotometric method (A), while in area under curve (AUC) method (B) the zero order spectrum of secnidazole was measured in between 315 - 325 nm. Beer’s law was obeyed in the concentration range of 2.5 to 15 μg/ml with coefficient of correlation value 0.9999 for zero order method. Similarly in AUC method, Beer’s law was obeyed in the concentration range of 2.5 to 15 μg / ml with coefficient of correlation value 0.9999. These methods were validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation were of 0.2811 % and 0.4046 % for the above two methods respectively. The proposed methods were successfully applied for the determination of secnidazole in pharmaceutical formulation. Results of the analysis were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply and low-cost.
Keywords
Secnidazole, UV Spectroscopy, Area Under Curve Method.References
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