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Rahul Jodh ¹, Mukund Tawar ¹, Prashant Burange ¹, Vedanshu Malviya ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602, IN

Abstract

In The family Orchidaceae, The plant Dactylorhiza hatagirea (D.Don) Soo, is recognized worldwide for its multi-fold benefits. Dactylorhiza hatagirea (D.Don) Soo Traditionally it used to cure various diseases like dysentery, diarrhoea, chronic fever, cough, stomach-ache, wounds, cuts, burns, fractures, general weakness. Dactylorhiza hatagirea (D. Doon) Soo frequently known as Hatajari and Salampanja in the region of Himalaya. Dactylorhiza hatagirea (D. Doon) Soo is a terrestrial orchid found in moderate climate in the alpine and sub-alpine region Indian Himalaya from 2800-4200 m above from sea level its Occurrence also present in Pakistan, Afghanistan, Nepal, Tibet and Bhutan In India, it predominantly found in region of Jammu and Kashmir, Sikkim, Arunachal Pradesh, Uttarakhand and Himachal Pradesh. Dactylorhiza hatagirea (D. Doon) Soo is collected chaotically from nature due to its high economic demand. the plant consist of different active compound which are responsible for various activity attributed on the plant. the present review emphasis on pharmacological activity of Dactylorhiza hatagirea (D. Doon) Soo which is establish by different authors.

Keywords

Dactylorhiza hatagirea (D. Doon) Soo, Himalayan Orchid, Salam Panja, Metformin

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Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Vishal Mahanur ¹, Yash Sureka ¹, Virendra Atole ¹

Affiliations
1 Department of Pharmacology, P. R. Pote Patil College of Pharmacy, Amravati-444604., IN

Abstract

The liver assumes a significant part in keeping up with the metabolic capacity and discharge of poisons from the body. A physical issue or liver brokenness brought about by the utilization of poisonous synthetics, over-the-top liquor and microorganisms bring about a difficult condition called hepatotoxicity. Madhuca longifolia having a place with Sapotaceae family is found to have pharmacological properties in the treatment of different disorders. Madhuca longifolia is likewise considered a therapeutic tree also, is helpful for outside application in treating skin infections, stiffness, migraine, persistent clogging, heaps, hemorrhoids, and ethno clinical properties like antibacterial, anxiolytic qualities, anticancer, hepatoprotective, antiulcer, antihyperglycemic, pain-relieving exercises, and so on. Leaves of mahua are utilized in the treatment of dermatitis, wound mending, anti-burn, bone crack, anthelminthic, emollient, skin illness, stiffness, and cerebral pain. The flowers are used as a tonic, pain-relieving, and diuretic; bark for an ailment, persistent bronchitis, and diabetes mellitus and leaves as an expectorant and constant bronchitis and Cushing's sickness. In this review we make a compilation focused on the synonyms, botanical description, phytochemicals, pharmacological activity, and medicinal uses of Madhuca longifolia.

Keywords

Madhuca longifolia, Pharmacology, Anti-anxiety, Phytocompounds, Utilization.

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Rahul Jodh ¹, Mukund Tawar ², Kiran Gomkale ², Sakshi Jari ², Jafer Toply ², Nawed Faisal ²

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602.
2 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

The structural isomer of the tetracycline family is doxycycline. It's a semi-synthetic medication with antibacterial properties against a wide range of germs and excellent intracellular penetration. Bacterial resistance can take many different forms, although the ribosomal or plasmid pathways are the most common. Propionibacterium acnes has gained antibiotic resistance in most cases due to an ARNr mutation. Doxycycline has antiinflammatory effects that manifest themselves through a variety of methods. Doxycycline is quickly absorbed and practically fully absorbed in the GI tract. Food does not affect absorption. With 90% of the molecule attached, it has a strong but fragile affinity for proteins. The majority of tissues and the extravascular compartment are swiftly absorbed. The most common method of excretion is through the bile canal. The bile channel is used for elimination. Tubular reabsorption in the kidney slows down. If you have acne, the daily dosage should be between 50 and 100 micrograms. Despite the scarcity of high-quality assays, there is widespread professional support for their use. It is also effective for rosacea at the same dosage. Doxycycline is being used as a backup antibiotic for chlamydial and mycoplasma urethritis. Additional diseases that can be treated as primary or secondary alternatives include treponematoses, brucellosis, pastoralizes, borreliosis, rickettsiosis, and cholera. Some non-infectious illnesses have been treated with doxycycline. The most common side effects are those that affect the digestive system. Esophageal poisoning has been treated with tablets and plenty of water.

Keywords

Antibiotics, Doxycycline, Tetracycline, Anti-microbial, P acne, Yersinia pestis.

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Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Yogiraj Ingole ¹, Tejas Deshmukh ¹, Vipul Ijapure ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati., IN

Abstract

Tobramycin is another aminoglycoside anti-microbial with a wide antibacterial range in vitro, and pharmacokinetic properties like those for gentamicin. Tobramycin is more dynamic than gentamicin against Pseudomonas aeruginosa and dynamic against numerous gentamicin safe strains, yet isn't dynamic against enterobacteriaceae impervious to gentamicin. Hypothetically, tobramycin enjoys an upper hand over gentamicin against diseases brought about by P. aeruginosa, yet any benefit in clinical practice presently can't seem to be enough illustrated. Clinical involvement in tobramycin is significantly not exactly with gentamicin. While tobramycin seems to offer no unmistakable benefits over gentamicin against touchy organic entities it is shown in contamination brought about by strains of P. aeruginosa which are impervious to gentamicin, yet touchy to tobramycin. Like gentamicin, tobramycin acts synergistically with carbenicillin and the cephalosporins. The viability of the tobramycin-carbenicillin blend has been displayed in endocarditis brought about by P. aeruginosa which was lethargic to gentamicin in addition to carbenicillin. Ototoxicity and nephrotoxicity like that seen with other aminoglycosides have been experienced in helpful preliminaries with tobramycin and more extensive clinical experience is important to decide the general occurrence of these incidental effects with gentamicin and tobramycin utilized under comparable conditions. Antimicrobial movement: In relative examinations, in vitro, tobramycin is more dynamic than gentamicin against clinical separates of Pseudomonas aeruginosa. Likewise, the inhibitory file, which is the proportion between the serum fixations accomplished at common remedial portions and the base inhibitory focus, for Pseudomonas aeruginosa is higher for tobramycin than for gentamicin.

Keywords

Antibiotic, Tobramycin, Aminoglycoside, Anti-microbial, Pseudomonas aeruginosa

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Vedanshu Malviya ¹, Mukund Tawar ², Prashant Burange ³, Rahul Jodh ³

Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
2 Department of Pharmaceutical Chemistry, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
3 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

Resveratrol can be recognized as a best nutraceutical. Resveratrol is a novel nutraceutical in which not many details are known therefore an attempt was made to review the details which may be used for the further research. Resveratrol is known to be a polyphenol named as stilbenoid group which is a phytoalexin secreted by more than 70 plant species which is having many pharmacological activities like anticancer, anti-inflammatory, anti-ageing, neuroprotective, cardioprotective, anti-microbial and etc. This natural table top food has a lower bioavailability with lower aqueous solubility. From this review we can conclude that resveratrol is a unique complex having various properties with lots of other benefits.

Keywords

Resveratrol, Natural Phenol, Phytoalexin, Grape Skin, Stilbenoid.

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Rahul Jodh ¹, Mukund Tawar, ¹, Prashant Burange ¹, Pradyumna Keche ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

Immunoglobulin’s are heterodimeric proteins composed of two heavy (H) and two light (L) chains. They can be separated functionally into variable (V) domains that binds antigens and constant (C) domains that specify effectors functions such as activation of complement or binding to Fc receptors. The variable domains are created by means of a complex series of gene rearrangement events, and can then be subjected to somatic hypermutation after exposure to antigen to allow affinity maturation. Immunoglobulin is the antibodies and glycoprotein’s molecules produced by plasma cells or white blood cells, a signal production occur due the reaction with B cells. In 20th century the science of immunoglobulin was considered as an important science, centrifugation, Immuno adsorption such novel techniques was discovered for dissection of human blood components such as antibodies, so the naming of antibodies was necessary, Latin terms was used at that time for the purpose of naming. But the various in vitro studies shows that the pepsin and acidic condition shows a degradative effect on immunoglobulin neutralizing titer. To overcome this the IgY antibodies are encapsulated. For the protection of mucosal membrane of the IgA plays an essential role, the immune response of the secretory IgA is short lived due to this the genetically engineered antibodies are used for passive immunotherapy.

Keywords

Immunoglobulin, Antibodies, Glycoprotein, Novel Techniques, Immunogens.

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