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Pullakhandam, Raghu
- Iron and Zinc Bioavailability from Madhukar × Swarna Derived Biofortifed Rice Lines
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PDF Views:103
Authors
Raghu Pullakhandam
1,
Surekha Agarwal
2,
V. G. N. Tripura Venkata
2,
C. V. Ratnavathi
3,
K. Madhavan Nair
1,
Sarla Neelamraju
2
Affiliations
1 ICMR-National Institution of Nutrition, Indian Council of Medical Research, Hyderabad 500 007, IN
2 ICAR-Indian Institute of Rice Research, Hyderabad 500 030, IN
3 ICAR-Indian Institute of Millets Research, Hyderabad 500 030, IN
1 ICMR-National Institution of Nutrition, Indian Council of Medical Research, Hyderabad 500 007, IN
2 ICAR-Indian Institute of Rice Research, Hyderabad 500 030, IN
3 ICAR-Indian Institute of Millets Research, Hyderabad 500 030, IN
Source
Current Science, Vol 118, No 3 (2020), Pagination: 455-461Abstract
Rice is the prime target of biofortification as it provides calories for about half of the world’s population. We assessed the iron (Fe) and zinc (Zn) bioavailability from polished rice grains of three high Fe and Zn recombinant inbred lines (RILs) using simulated in vitro digestion/Caco-2 cell model. Ferritin induction and 65Zn uptake were used as surrogate for Fe and Zn bioavailability respectively. Fe and Zn concentration in both unpolished and polished rice grains of three RILs was higher compared to Swarna, a parent and popular variety used as control. The grain Fe concentration was positively correlated (r = 0.94) to Zn concentration. There was a 2-fold induction of ferritin (42.4 ± 3.2 ng/mg protein) in Caco-2 cells only in the presence of ascorbic acid and 3-fold increase in 65Zn uptake (17.7 ± 2.4 pmol/mg protein) from the RIL 185M compared to Swarna (ferritin: 24.8 ± 4.0 ng/mg protein; 65Zn uptake: 5.8 ± 0.3 pmol/mg protein). Phytic acid was highest (8.75 mg/g) in 185 M but that did not affect bioavailability of Fe and Zn. Thus, improving the density of Fe and Zn in grains of conventionally bred rice lines has the potential to enhance the bioavailability of Fe and Zn.Keywords
Ascorbic Acid, Caco-2 Cells, Ferritin Induction, Phytic Acid, Recombinant Inbred Lines.Full Text
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- Calcium and vitamin D supplementation to pregnant women in urban hospital and community settings
Abstract Views :241 |
PDF Views:1
Authors
Affiliations
1 Division of Public Health Nutrition, Nutrition Foundation of India, New Delhi, Delhi - 110 016, IN
2 National Institute of Nutrition, Hyderabad - 500 007., IN
1 Division of Public Health Nutrition, Nutrition Foundation of India, New Delhi, Delhi - 110 016, IN
2 National Institute of Nutrition, Hyderabad - 500 007., IN
Source
The Indian Journal of Nutrition and Dietetics, Vol 60, No 1 (2023), Pagination: 1-16Abstract
In India, calcium intake is low and the prevalence of Vitamin D deficiency in pregnant women is high. The National Guidelines envisage elemental calcium 500 mg (as calcium carbonate salt) and 250 IU vitamin D supplements should be provided to pregnant and lactating women. In Delhi, iron folic acid tablets are given twice a day after meals in anaemic women and one tablet of calcium and vitamin D daily after a meal in all pregnant women. A study was taken up to assess the availability and compliance with calcium and vitamin D supplementation in primary health care institutions under research (Group 1 - 387 women) and service conditions (Group 2 - 400 women) and in urban community setting (Group 3 - 448 women). Women in Group 1 received Ca and Vitamin D tablets regularly from the research staff. In Group 2 and Group 3 tablets, were provided as and when government supplies were available and prescriptions were given when they were not available. Ca and Vitamin D tablets were expensive; families bought the tablets as and when they had the funds. As a result, the number of tablets available for consumption was lower in Group 2 and 3. In all three groups, side effects were rare and nearly all available tablets were consumed. In Group 1, Vitamin D estimation was done at enrolment and after supplementation for three months; 83% of women at enrolment and 68% of women after three months of supplementation had serum vitamin D levels below 20 ng/ml. These data suggest that one tablet of Ca and Vit D per day is insufficient for correcting maternal vitamin D deficiency. It is essential to carry out studies to assess the impact of supplementation with two tablets of Ca and Vit D on maternal vitamin D levels.
Keywords
Vitamin D Deficiency in Pregnancy, Calcium and Vitamin D Supplementation, Availability of Calcium and Vitamin D Supplements, Compliance With Supplementation, Impact of Supplementation
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