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Venkatanarayanan, R.
- Pharmacological Evaluation of Antiasthmatic Activity of Tamarindus indica Seed
Authors
1 Department of Pharmacology, R. V. S. College of Pharmaceutical Science, 242, Trichy Road Sulur, Coimbatore-641 402., IN
2 Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 3 (2011), Pagination: 115-122Abstract
Practical experience and several modern research studies have shown that therapy using plant is better than using synthetic chemicals. According to ayurvedic folklore the Tamarindus indica Linn was mentioned for several ailments including asthma (kirtikar et al; 2001) the present study was planned to know the anti asthmatic activity of methanolic extract of this plant at different stages or different types of asthma using various evaluation models like, isolated goat tracheal chain preparation, bronchial hyperactivity, clonidine induced catalepsy in guinea pig, mast cell degranulation, milk induced leucocytosis in mice, milk induced eosinophilia in mice, passive paw anaphylaxis, and its activities such as bronchodilating, antihistaminic, anti inflammatory , anti allergic, mast cell stabilizing and adaptogenic activities were confirmed presenting the scope of plant for further studies. The data was analyzed by student't' test or one way ANOVA followed by Dunnett test. P≤0.05 was considered as significant.Keywords
Tamarindus Indica Linn., Catalepsy, Leukocytosis, Anaphylaxis, Degranulation.References
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- Analysis of Crude Drugs Present In the Hepatoprotective Polyherbal Formulation by HPTLC Technique
Authors
1 Department of Pharmacognosy, R.V.S College of Pharmaceutical Sciences, Sulur, Coimbatore – 641 402, Tamil Nadu, IN
2 Department of Pharmacognosy, R.V.S College of Pharmaceutical Sciences, Sulur, Coimbatore, IN
3 Department of Pharmacognosy, College of Pharmacy, Mother Theresa Institute of Health Sciences and Research Institute, Pondicherry, IN
4 Department of Biochemistry, SASTRA University, Tanjore, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 261-265Abstract
Extracts of crude drugs such as Ajowan, Mace, Cardamom, Cumin, Nutmeg and Clove used in the Polyherbal formulation - RVSPHF567 were taken in account and dissolved in their appropriate solvents. These extracts were analyzed individually by High Performance Thin Layer Chromatography (HPTLC) to detect the presence of their phytoconstituents. The instrument used for High Performance Thin Layer Chromatography (HPTLC) was CAMAG LINOMAT 5. These analytical investigations were highly useful for preparing Polyherbal formulation - RVSPHF567 which is highly effective as Hepatoprotective agent and can be used in-vivo as a potential therapeutic agent. The sample was prepared by solvent extraction. Then 2μl of test solution was loaded as 6mm band length on the 9 x 10 Silica gel 60F254 TLC plate. This was done by using Hamilton syringe. These plates were kept in respective mobile phase Chloroform: Methanol: Water (6.5: 2.5: 0.4) for spot development to 90mm. These plates were dried and kept in Photo-documentation chamber - CAMAG REPROSTAR 3. The images were captured at White light, UV 254nm and UV 366nm. The developed plates were sprayed with respective spray reagent and photo-documented in White light and UV 366nm mode. Then the same were scanned at 500nm. The Peak table, Peak display and Peak Densitogram show the terpenoids profile in all the crude drugs.
Keywords
Polyherbal, Liver Protective.- Anti-Inflammatory Activity Screening of Methanolic Extract of Bryophyllum pinnatum Root
Authors
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
2 Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
3 Department of Pharmacognosy, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 14, No 1 (2022), Pagination: 1-3Abstract
An inflammatory response appears after activation of immune response. Inflammation is a response to remove the primary cause of cell injury. Dead cells, damage tissue sand initiate the repair process. Inflammation may be of two types acute and chronic. Medicinal plants has a potential source of therapeutic aid has a attended a significant role in all over the world for both human and animals not only in the disease condition but also a potential for maintaining a proper health. The plant Bryophyllum pinnatum species (roots) are evaluated for anti-inflammatory activity. Aim: Anti-inflammatory activity of Bryophyllum pinnatum was evaluated using Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Materials and Methods: To prepare methanolic extracts of Bryophyllum pinnatum roots and investigate the anti-inflammatory activity by Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Result: The result obtained indicates that the extract found to have significant (p<0.0001) anti-inflammatory activity in rats. The extract at the test doses 200mg/kg reduced the oedema induced by carrageenan by 41.26% at 3 h, whereas the standard drug showed 47.35% of inhibition ass compared to the control group. Conclusion: The methanolic extract of Bryophyllum pinnatum are safe upto 500mg/kg for continues administration and it can be used as anti inflammatory agent without any harmful effectsKeywords
Inflammation, Oedema, Therapeutic aid, anti-inflammatory activity, Histamine.References
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