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Patel, R.
- Delayed Peripheral Neuropathy Due to Organophosphate Tri-Ortho-Cresyl Phosphate Poisoning
Authors
1 Department of Medicine, B J Medical College, Ahmedabad, IN
Source
The Indian Practitioner, Vol 69, No 6 (2016), Pagination: 52-54Abstract
Introduction: 15 patients were admitted to Civil Hospital, Ahmedabad with complains of cramping pain and weakness in bilateral lower limbs. They were found to be suffering from subacute motor neuropathy.
Material And Methods: All were investigated for abnormalities in complete haemogram, blood biochemistry, B12 levels, nerve conduction studies and cholinesterase levels. Results: There was distal muscle weakness in bilateral lower limbs with loss of deep tendon reflexes in lower limbs with EMG suggestive of axonal and demyelinating neuropathy with reduced RBC cholinesterase levels. Discussion: From history and investigations it was found that the ingestion of wheat contaminated with tri-ortho-cresyl phosphate (TOCP) lead to axonal and demyelinating type of polyneuropathy.
Keywords
Delayed Neuropathy, Tri-Ortho-Cresyl Phosphate.
References
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- Study of Dengue Fever with Outcome Analysis in Patients with Normal and Abnormal Liver Function Tests
Authors
1 GMERS Medical College and Hospital, Sola, IN
2 Department of Medicine, GMERS Medical College and Hospital, Sola, IN
Source
The Indian Practitioner, Vol 69, No 9 (2016), Pagination: 11-16Abstract
Background: Study of 100 cases of dengue fever with comparison of outcome in patients with abnormal liver function test v/s normal liver function test.
Methods: An observational and analytical study conducted in GMERS medical college and hospital sola Ahmadabad. 100 adult age 18-75 years patients were included in time period of April, 2014 to April, 2015. Cases of Dengue fever were taken for study presenting with two or more symptoms of dengue fever and positive serology. Routine investigations, liver function tests and ultrasonography of abdomen were carried out. Measurement of outcome with regards to complication, mortality and Length of stay were studied.
Results: Out of 100 patients 60 were Classical DF, 31 DHF and 9 were of DSS. Fever was the most common and Nausea and vomiting was the next common complaint. Significant percentage of Epistaxis and Bleeding were observed in DHF (48.4%) group of patients. Average total bilirubin at presentation was markedly elevated in DSS (2.02±1.38) in comparison to DHF (1.28±1.02) and Classical DF (0.84±1.00) (P<0.05). Average SGPT at presentation was observed to be significantly higher in DSS group (351.38±402.75) followed by DHF (120.56±95.20) and Classical DF (95.40±66.55) group. The difference was statistically significant (P<0.05). Average peak APTT observed to be higher in DSS (44.8±8.2) group followed by DHF (42.2±13.0) and Classical DF (39.6±9.4). SGOT at presentation and the peak value of SGOT with bleeding episodes was observed to be statistically significant. The average length of hospital stay was 5 days. Correlation between average SGOT and average length of stay in the groups with Classical DF and DSS was statistically significant (P<0.05).
Conclusion: Altered liver function test in dengue infection has got effect in terms of length of stay and complications as compared to normal or mild alteration of liver function test. Therefore high SGOT and SGPT can be considered as a prognostic marker of outcome in dengue infection.
Keywords
Dengue Fever, Liver Function, Outcome, Length of Stay, Mortality.References
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Authors
1 Dept. of Chemistry, S.S.L. Jain. P.G. College, Vidisha (M.P), IN
2 Ayurvedic Drug Reserch Lab, S.S.L. Jain.P.G. College, Vidisha (M.P), IN
3 TIT College of Pharmacy, Bhopal (M.P), IN