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Balabhaskar, R.
- Comparative Biochemical Evaluation on Nutraceutic and Phytotherapeutic Properties of Mengkudu and Midshipman’s Butter – Review
Authors
1 PG Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota 20300, Kuala Terengganu, MY
Source
Research Journal of Science and Technology, Vol 3, No 5 (2011), Pagination: 232-237Abstract
Background: Rasayana is a branch of Ayurveda which deals with the ability of the herb to bestow upon the body enhanced capacity of warding off infections and delaying the ageing process. Indigenous natural products have become the alternative way to replace the synthetic medicine.
Aim: This review gives an account of the current knowledge on the Pharmacognosy, phytochemistry and pharmacological aspects of Mengkudu (Morinda citrifolia-Rubiaceae) and Midshipman’s butter (Persea americana- Lauraceae), the ethno medicinal plants.
Nutraceutics: A wide range of phytoconstituents mainly alkaloids, flavonoids, terpenoids, phenolics, vitamins, minerals and many more compounds whose activities have been proved are present in both the fruit extracts.
Pharmacology: The fruits of both plants have been used in traditional medicines to prevent, treat, and cure both communicable and non communicable diseases.
Conclusion: The present review includes detailed epidemiology, phytochemistry, and pharmacological aspects of aqueous extracts of fruits of Mengkudu and Midshipman’s butter in an attempt to provide a direction for further research.
Keywords
Pharmacognosy, Phytochemistry, Pharmacology, Nutraceutics, Epidemiology.- Evaluation of Anticancer activity of Ethanol extract of Bauhinia tomentosa Linn. on A549, Human Lung Carcinoma Cell lines
Authors
1 Department of Biochemistry, Bharathiar University. Coimbatore–641046, IN
2 Department of Biochemistry, Bharathi Women’s College, Chennai–600108, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 6 (2019), Pagination: 2748-2752Abstract
Objective: The aim of the present study is to evaluate the anticancer activity of ethanol extract of B.tomentosa (EBT). Methods: The anticancer activity of ethanol extract of B.tomentosa was evaluated by MTT Assay, AO/EtBr Fluorescence assay and DNA Fragmentation assay against A549 (human lung cancer cell line). Results: Treatment of A549 cells with EBT (at IC50 concentration) for 48 hrs significantly inhibited the proliferation in a concentration dependent manner. AO/EtBr staining confirms the occurrence of apoptosis in A549 cells after the treatment of EBT. From DNA fragmentation assay, it is evident that EBT has also significantly induced DNA damage in treated A549 cells. Conclusion: Thus the present study demonstrates the anticancer activity of EBT. The ethanol leaf extract of B.tomentosa has shown potent anticancer activity on A549 cancerous cell line. Further studies are needed to identify the bioactive molecules and to explore its mechanism of action which might throw light in the development of new alternative drug for lung cancer.Keywords
Anticancer Activity, B.tomentosa, MTT Assay, AO/Et Br, DNA Fragmentation, A549.References
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