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Chaudhari, R. Y.
- Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology
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Authors
C. P. Suryawanshi
1,
V. R. Patil
1,
R. Y. Chaudhari
1,
M. K. Kale
2,
S. D. Firake
2,
R. B. Pimprikar
3,
M. D. Patil
3,
S. B. Yeshwante
3,
D. S. Saindanem
3
Affiliations
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease.Keywords
Parkinson's Disease, Oxotremorine, Tremor, Procyclidine.References
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- Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones
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Authors
Affiliations
1 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), IN
2 TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), IN
1 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), IN
2 TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), IN