Informatics Publishing Limited

A. R. Umarkar ¹, A. K. Raut ², S. S. Sonone ², S. S. Pawar ², R. S. Deshmukh ², N. V. Bharude ²

Affiliations
1 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research Jamner Dist: Jalgaon. [M.S], IN
2 Shree Sureshdada Jain Institute of Pharmaceutical Education and Research Jamner, Dist: Jalgaon. [M.S], IN

Abstract

Diabetes is a major cause of morbidity and mortality worldwide. Prevalence of diabetes is on rise in India and it may reflect changes in lifestyle. Major complications of diabetes are neuropathy, nephropathy, coronary artery disease and retinopathy. Improper diets, immigration effects, modification in life style, inter-population differences and obesity are the principal reasons for the augmentation of the diabetic prevalence. Diabetic prevalence in Chennai, Andhra and Kerala are 15.5%, 13.2% and 12.4% respectively. It has been estimated that India may have 80 million diabetic people in the year of 2030. Therefore, providing safe and effective measures are the need of the hour to control the explosion of the disease in India particularly its southern. The present review article gives a brief overview of diabetes, different factors leading to the increase in diabetic occurrence and complications particularly localizes in India.

Keywords

Diabetes, Type-1, Type-2, Insulin.

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R. S. Deshmukh ¹, A. M. Shingi ¹, V. K. Bairagi ²

Affiliations
1 Sinhgad Academy of Engineering, Affiliated to Pune University, Pune, IN
2 College of Engineering, Pune, IN

Abstract

Phone Radiation and Health concerns have been raised, particularly following the huge boost-up in the use of wireless mobile telephony all through the world. Mobile phones uses electromagnetic radiation in the microwave range and some people consider this might be damaging to human health. These concerns have induced a hefty body of research. In this paper, we have developed hardware to measure the radiation of mobile phones. We have done comparative study of all models of handsets from various companies in India. The analysis is done in metro city-Pune.

Keywords

Mobile Phone Radiations, EMI.

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R. K. Nanda ¹, S. E. Potawale ¹, V. V. Bhagwat ¹, S. C. Hamane ¹, R. S. Deshmukh ²

Affiliations
1 D.Y.Patil Pratishthan’s Padmashree Dr. D.Y.Patil Institute of Pharmaceutical, Sciences and Research, Pimpri, Pune-411018, IN
2 Sinhgad College of Pharmacy, Vadgaon, Pune-411041, IN

Abstract

A simple, precise, accurate and rapid HPLC method has been developed, and validated for the determination of Aspirin, Atorvastatin Calcium simultaneously, in combined dosage form. Acetonitrile: 0.02 M Phosphate buffer with pH 6.1 (50%:50% v/v) is used as the mobile phase, pH adjusted with Sodium Hydroxide (1% aqueous). Mobile phase was delivered at the flow rate of 1.0 ml/min., 239 nm is the detection wavelength for this study. The applicability of the method for simultaneous determination of Aspirin, Atorvastatin Calcium was verified by the determination of these compounds in marketed capsules. Results of the analysis were validated statistically, and by recovery studies. Linearity for Aspirin And Atorvastatin Calcium was in the range of 5-35 μg/ml and 1-7 μg/ml, respectively and reproducibility was found to be satisfactory. The % assay (Mean±S.D.) was found to be 99.33±0.501 and 101.4±0.18 for Aspirin and Atorvastatin Calcium respectively. The recovery and RSD values are within the limits given in ICH guide lines. Method development indicates the suitability of proposed method for the routine determination of these compounds in capsule dosage form. The proposed method can be successfully used to determine the drug contents of marketed formulation.

Keywords

RP-HPLC, Validation, Aspirin, Atorvastatin.

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R. K. Nanda ¹, S. E. Potawale ¹, V. V. Bhagwat ¹, S. C. Hamane ¹, R. S. Deshmukh ²

Affiliations
1 Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, IN
2 Sinhgad College of Pharmacy, Vadgaon, Pune-411041, IN

Abstract

A simple, precise and economical procedure for the simultaneous estimation of Aspirin and Atorvastatin Calcium in capsule formulation has been developed. The first method employs simultaneous equations (Method I) which involve absorbance measurement at 225.5 nm (λ max of Aspirin) and 246.0 (λ max of Atorvastatin Calcium). Second method involves absorbance ratio (Method II), which uses the ratio of absorbances measured at two selected wavelengths, one at isoabsorptive point (232.5 nm) and other being the max of one of the two compounds. Third method involves measurement of area under curve (AUC). For this method wavelength ranges were chosen between 223.5-227.5 nm and 244-248 nm for Aspirin and Atorvastatin Calcium respectively. Results of analysis for methods were tested and validated for various parameters according to ICH guidelines, hence can be adopted for the routine analysis of Aspirin and Atorvastatin Calcium in tablet dosage form.

Keywords

Aspirin, Atorvastatin Calcium, Simultaneous Equation Method, Absorbance Ratio Method, Area Under Curve Method.

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Sanjay P. Pandhare ¹, K. R. Nadre ¹, R. S. Deshmukh ², P. B. Bhosale ¹

Affiliations
1 Department of Extension Education, College of Agriculture, Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
2 AICRP-Extension, College of Home Science, Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN

Abstract

Present investigation was carried out in five KVK's under State Agricultural Universities of Marathwada region of Maharashtra state to know the participation of farmers, their attitude towards KVK's, constraints in adoption of KVK recommended practices and suggestions given by the respondents. Keeping the objectives in mind, the the list of beneficiaries was obtained from KVK which acts as beneficiary population. Fifty beneficiaries from each course were selected by using n^th number method from respective beneficiaries. Same number of non-beneficiary respondents were randomly selected from outside the population. Thus, 150 beneficiaries and 150 non-beneficiaries formed the sample for the study. The respondents were personally interviewed with a well-structured and pre-tested interview schedule. From the study, it was observed that majority of beneficiaries had medium level of participation in the KVK activities. More than three fourth of the beneficiary were having moderately favourable attitude towards KVK. Lack of knowledge, costly inputs, unavailability of materials and labours, were constraints noted by the farmers in their adoption of KVK recommended practices. They also replied with suggestions like, organize timely and frequent demonstrations, give technical know how of improved practices. Data were analysed by using mean, percentage, frequency and 'Z' test for comparison.

Keywords

Participation, Attitude, Beneficiaries.

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S. P. Pandhare ¹, K. R. Nadre ¹, R. S. Deshmukh ¹, P. B. Bhosale ²

Affiliations
1 Department of Extension Education, College of Agriculture, Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
2 AICRP-Extension, College of Home Science, Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN

Abstract

Present investigation was carried out in four KVK's under State Agricultural Universities of Maharashtra state to know the profile of the respondents, adoption of recommended practices of KVK and their relation with their profile. Keeping the objectives in mind, the list of beneficiaries was obtained from KVK which acts as beneficiary population. Fifty beneficiaries from each course were selected by using n^th number method. Same numbers of non-beneficiary respondents were randomly selected from outside the population. Thus, 150 beneficiaries and 150 non-beneficiaries formed the sample for the study. The respondents were personally interviewed with a well-structured and pre-tested interview schedule. From the study it was observed that most of the respondents were middle aged, educated up to Higher Secondary and College level, with medium land holding farming experience and annual income, agriculture + business as their occupation. Whereas socio-economic status, economic motivation, infrastructural facilities, sources of information of the respondents and knowledge about selected KVK recommended practices had shown extent of their existence up to medium level. Majority of the respondents were found in medium level adoption of organic manures and pesticides, sweet orange cultivation practices and dairy animals management practices. In case of correlation coefficient, education, land holding, annual income, socio-economic status, economic motivation, infrastructural facilities, sources of information, knowledge and attitude towards KVK of the beneficiaries were having significant and positive relationship with all the selected courses. While socio-economic status, economic motivation, knowledge and attitude towards KVK were significant contributors for adoption of KVK recommended practices. Data were analysed by using mean, percentage, frequency, correlation and multiple regression.

Keywords

Adoption, Recommended Practices, Beneficiaries.

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