Informatics Publishing Limited

Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

Heterocyclic compounds such as 5-substituted and 5,6-disubstituted-2-(N, N-dialkyl Thiocarbamido) benzimidazoles were synthesized by condensation of 5-substituted and 5,6-disubstituted-2-mercapto benzimidazoles with N, N-dialkyl carbamoyl chlorides and triethyl amine in dry 1,4-dioxane. Synthesized compounds were further screened for their biological activity and found to have good to moderate antibacterial and antifungal activity. The structures of compounds have been established on basis of their elemental analysis and spectral data (IR and NMR).

Keywords

Mercapto Benzimidazole, Antifungal, Antibacterial, N, N-Dialkyl Carbamoyl Chloride.

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Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

Heterocyclic compounds such as 5-substituted-2-(1-H-benzimidazole) sulfonamides were synthesized by condensation of 5-substituted-2-(1-H-benzimidazole)-sulfonyl chloride and 2-aminoheterocycles with triethyl amine in dry acetone. The synthesized compounds were checked for their antimicrobial potency by screening them against two bacterial strains as well as one fungal strain. The structures of compounds have been established on the basis of their elemental analysis and spectral data.

Keywords

Sulphonamides, 2-Mercapto Benzimidazole, Antifungal, Antibacterial.

Full Text

     

Y. S. Rane ¹, R. R. Varma ¹, L. S. Patil ¹, S. V. Athlekar ¹, A. S. Chowdhary ¹, A. S. Bobade ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, IN

Abstract

A series of benzimidazole phenylthiocarbamoyl derivatives were synthesized by condensing substituted 2-mercaptobenzimidazole with substituted benzoyl chlorides. These benzimidazole derivatives were evaluated for their antibacterial activity against Gram Positive bacteria Staphylococcus aureus (ATCC 3750) and Gram Negative bacteria Salmonella typhi (NCTC 786), as well as antifungal activity against a fungal strain Candida albicans (ATCC 10231). It was observed that the 5-naphthoxy-6-chloro benzimidazole derivatives having dichloro substitutions on the phenylthiocarbamoyl part of the molecule showed better activity than the rest.

Keywords

Benzimidazole, Antimicrobial, Phenylthiocarbamoyl Derivatives, Benzoyl Chloride.

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