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Agrawal, R. C.
- Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice
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Authors
Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 87-90Abstract
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.Keywords
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.
References
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- Antimutagenic Effects of Tribulus terristris Fruit Extract on Micronucleus
Abstract Views :151 |
PDF Views:1
Authors
Affiliations
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN
2 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal (MP), IN
1 Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, IN
2 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal (MP), IN
Source
Research Journal of Science and Technology, Vol 4, No 3 (2012), Pagination: 140-142Abstract
In this study, the protective effect of hydromethanolic fruit extract of Tribulus terristris is reported against Cyclophosphamide (CP) induced micronuclei (MN) formation in bone marrow cells of mice. Swiss albino mice were treated with a single i.p. dose of 500, 1000 and 1500 mg/kg b.w. with Tribulus terristris fruit extract prior to CP administration. A significant inhibition was noticed in the micronuclei frequencies, as it gradually decreased with increase in concentration of the extract suggesting a protective effect and the extract alone had not induced MN formation, reiterating the fact that the extract has no pro-mutagenic components.Keywords
Micronucleus, Mutagenic, Tribulusterristris, Hydromethanolic.- In Vitro Antioxidant Activity and Phytochemical Screening of Aegle marmelos Extracts
Abstract Views :150 |
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Authors
Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal (MP), IN
2 Dept. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah Hills, Bhopal (MP), IN
2 Dept. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 80-83Abstract
Antioxidant activity and phytochemical screening of hydromethanolic extracts of Aegle marmelos fruit, leaves and bark were investigated in this work. Phytochemical screening of the crude extracts revealed the presence of Alkaloids, glycosides, Terpenoids, Saponins, Tannis, Flavonoids, and Steroids. Antioxidant activity of the extracts was evaluated using Fenton reaction: an in vitro assay and the extracts showed high hydroxyl radical scavenging property when compared with Ascorbic acid, which was used as reference standard. These findings demonstrated that Aegle marmelos extracts possess free radical and hydroxyl radical scavenging activity as well as antioxidant activity in vitro.Keywords
Aegle marmelos, Antioxidant, Phytochemical Constituents, Hydromethanolic.- Effect of Phyllanthus niruri Leaf Extract on Antioxidant Activity and UV Induced Chromosomal Aberration in Swiss Albino Mice
Abstract Views :146 |
PDF Views:0
Authors
Affiliations
1 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, MP, IN
2 Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal- 462001 Madhya Pradesh, IN
3 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, Madhya Pradesh, IN
1 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, MP, IN
2 Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal- 462001 Madhya Pradesh, IN
3 Research and Development Department, Sonic Biochem Extraction Ltd., Mandideep, Bhopal, Madhya Pradesh, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 6 (2011), Pagination: 300-303Abstract
In the recent study of investigation, the genotoxic effect of leaf extract of Phyllanthus niruri has been analysed against UV- induced chromosomal aberration in the bone marrow cells of mice. Single i.p. administration of Phyllanthus niruri leaf extract at three different doses namely 250, 500 and 750 mg/kg b. wt. have provided protection when given 24 hr prior to the exposure of Ultra Violet radiation (UV B, 315 nm). A dose inhibition of chromosomal aberration was observed which was statistically significant (p<0.05) as compared to the UV treated group. In another set of experiment, the antioxidant activity of Phyllanthus niruri leaf extract using Fenton reaction was also observed and we found a dose dependent inhibition of Thiobarbituric acid reactive substance (TBARS) as compared to positive control. The minimum inhibitory concentration 50% of P. niruri and DMSO was found to be 68.76 and 56.98 respectively. Its seems to have a preventive potential against UV induced chromosomal aberrations in the bone marrow cells of the mice and also found antioxidant activity. Therefore, the results suggest a genotoxic and antioxidant potential of Phyllanthus niruri leaf extract.
Keywords
Genotoxicity, Ultra Violet, Phyllanthus niruri, Bone Marrow, Chromosome, Antioxidant Activity, Radioprotector.- Antimicrobial Activity of Bauhinia variegata Leaves (Ethanolic) Extract
Abstract Views :144 |
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Authors
Affiliations
1 Department of Pharmacology, MES’s College of Pharmacy Sonai, Ahmednagar, (M.S.), 414105, IN
2 Jawaharlal Nehru Cancer Hospital and Research Center, Bhopal, (M.P.), IN
1 Department of Pharmacology, MES’s College of Pharmacy Sonai, Ahmednagar, (M.S.), 414105, IN
2 Jawaharlal Nehru Cancer Hospital and Research Center, Bhopal, (M.P.), IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 5 (2011), Pagination: 244-246Abstract
Purpose: The antimicrobial activity of the 50 % methanolic extract of the leaves of Bauhinia variegata. (Leguminosae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections.
Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains.
Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus epidemidis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. - 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Pseudomonas aeruginosa and Shigella floxineri
Conclusion: The results demonstrate that the crude extract of the leaves of Bauhinia Variegata has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria.
Keywords
Antimicrobial Activity, Bauhinia variegata, Methanol Extract.- Social Equity Measures in the Agricultural Higher Education System
Abstract Views :106 |
PDF Views:66
Authors
Affiliations
1 National Agricultural Higher Education Project, ICAR HQ, New Delhi 110 012, IN
1 National Agricultural Higher Education Project, ICAR HQ, New Delhi 110 012, IN
Source
Current Science, Vol 124, No 5 (2023), Pagination: 539-546Abstract
Agricultural education is crucial to produce skilled human resources to take up present and emerging challenges faced by Indian agriculture. Over the last decade, agricultural higher education attractiveness has improved due to access to quality education, attractiveness in employment market, and widening career opportunities across social and geographical areas. While continuing to provide better quality and more relevant education in agriculture, ICAR, in association with World Bank, initiated National Agricultural Higher Education Project (NAHEP) in 2017. The project development objective is to enhance the quality and relevance of agricultural higher education in the country. NAHEP has also adopted social inclusion by providing national and international training to student and faculty. In addition, various special initiatives are being undertaken to enable access to the essential amenities for differently abled, female students and faculties. To take it forward and make it sustainable, this article also suggests key measures.Keywords
Agricultural Higher Education System, Equity Action Plan, Gender Equality, Skilled Human Resource, Social Equity.Full Text
References
- Agarwal, R. C. et al. (eds), Response Catalogue of International Training under NAHEP. Project Implementation Unit (PIU), National Agricultural Higher Education Project (NAHEP), Agricultural Education Division, Indian Council of Agricultural Research (ICAR), New Delhi, 2020; https://heyzine.com/flip-book/b73c2f8f51.html#page/2
- NAHEP, Annual Report, PIU, NAHEP, Agricultural Education Division, ICAR, New Delhi, 2020-21; https://nahep.icar.gov.in/pdf/NAHEP%20Book%202021%20Final.pdf
- GoI, National Education Policy. Ministry of Human Resource Development, Government of India, 2020, pp. 41–42; https://www.education.gov.in/sites/upload_files/mhrd/files/NEP_Final_English_0.pdf
- Tripathi, H. et al. (eds), Nurturing Social Equity under NAHEP, PIU, NAHEP, Agricultural Education Division, ICAR, New Delhi, 2022; https://nahep.icar.gov.in/NahepAchievement/NuturingSocialEquity-NAHEP-6th%20June
- http://www.jnu.ac.in/RTI/Admission%20Policy.pdf