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Pushpendra K. Patel ¹, Jyoti Sahu ¹, Narendra K. Prajapati ¹, B. K. Dubey ¹, A. Alia ²

Affiliations
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal. M.P., IN
2 Rajiv Gandhi College, Bhopal, IN

Abstract

The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion. This organ plays a major role in metabolism and has a number of functions in the body including glycogen synthesis, hormone production, and detoxification. Excess consumption of N.S.A.I.D. and alcohol causes the liver disease. Madhuca indica that is also known as mahua in different parts of the country belonging to the family Sapotaceae is having several medicinal properties. The leaves of Mahua tree contain saponin, an alkaloid, and glucoside. Sapogenin and other basic acid are found in the seeds. Various Photochemical studies on Mahua include characterization of Sapogenin, triterpenoids, steroids, saponin, flavonoids and glycosides. Madhuca indica has several pharmacological activity, and potential to provide health to the society. It is used as Anti diabetic, antiulcer, hepato protective, anti pyretic, anti fertility, analgesic, anti oxidant, swelling, inflammation, piles, emetic, dermatological, laxative, tonic, anti burn, anti earth worm, wound healing headache and many more problems. The ethanolic extract of Madhuca indica at 200 mg/kg and 400 mg/kg produce significant hepatoprotective effect against paracetamol induced hepatotoxicity. Different parameters such as physical, Histopathological and biochemical studies like ALT, SGOT, SGPT, bilirubin test had been included in the study which provides the satisfactory data to conclude the hepatoprotective effects of Madhuca indica.

Keywords

Madhuca indica, Mahua, Hepatoprotective, CCl₄, Liver Disease.

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Pushpendra K. Patel ¹, Narendra K. Prajapati ¹, B. K. Dubey ¹

Affiliations
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anad Nagar, Bhopal, Madhya Pradesh, IN

Abstract

Liver is one of the most important organs of body and performs several functions, so it has to be keep safe and healthy. Due to the several reasons like alcohol consumption, side effect of drug, liver is get damaged. Liver damage can be cure by the use of allopathic medicine, but the disadvantage of allopathic medicine are their side effect and they may cause other health issue, so one has to use the herbal medicine for the treatment purpose. India is a rich country in the herbal medicine, it has world oldest medicinal book Ayurveda, and it contains endless information about the disease, symptoms and their cure too. It has several plant showing liver protective like Aegle marmelos, Madhuca indica, glycyrriza glabra, phyllanthus niruri, cordial macleodii, Aloe barbadensis, Glycyrrhiza glabra, Decalepis hamiltonil, Euphorbia fusiformis, Halenia elliptica, Casia fistula, Piper chaba, Schouwia thebica, Momordica dioica, Asparagus racemosus, Cajanus cajan, Amomum sublatum, Flacourtia indica, Epaltes divaricata, Anisochilus Carnosus, Aervalanata. Looking upon the importance of herbal medicine in the treatment of liver disease, it is necessary to bring traditional knowledge and modern science into a same platform. If they will work together then the outcome will be blasting in the field of medicine, than there will be no more category of herbal and synthetic medicine, there will be only one secure medicine.

Keywords

Hepatoprotective, Hepetotoxicity, Aegle marmelos, Madhuca indica, Herbal Medicine, Toxic Effect.

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