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Kulkarni, Preeti
- Status of Technology Transfer in India - the much Needed Magic Remedy
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PDF Views:86
Authors
Affiliations
1 Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410 210, IN
2 National Institute of Pharmaceutical Education and Research, Mohali, Chandigarh 160 062, IN
3 Gahlot Institute of Pharmacy, Navi Mumbai 400 079, IN
1 Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai 410 210, IN
2 National Institute of Pharmaceutical Education and Research, Mohali, Chandigarh 160 062, IN
3 Gahlot Institute of Pharmacy, Navi Mumbai 400 079, IN
Source
Current Science, Vol 106, No 8 (2014), Pagination: 1058-1060Abstract
Various strategies and models have been developed to implement successful technology transfer in Indian universities, many of which are inspired from existing approaches in developed countries such as the United States. This article provides an insight on the prevailing strategy and ways to streamline technology transfer in the Indian academic scenario.Full Text
- Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis
Abstract Views :67 |
PDF Views:0
Authors
Chetan Savant
1,
Venkatrao Kulkarni
1,
Prasanna Habbu
2,
Preeti Kulkarni
1,
Muhammed Majeed
3,
Mahadeva Nayak
3
Affiliations
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, IN
3 Sami Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, IN
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, IN
3 Sami Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 19 - 23Abstract
Herbal drugs are used widely even when their biologically active compounds are unknown, probably because of their effectiveness, lesser side effects and affordability. In the present study we investigated the potential cardio- protective effect of combination of standardized extracts of Terminalia arjuna and Ocimum sanctum in isoproterenol induced myocardial infarction. Myocardial infarction was induced in rats by subcutaneous injection of Isoproterenol for two consecutive days at an interval of 24h. Rats were pre-treated with test drugs for the period of 21 days and Isoproterenol was administered on 20 and 21st day. At the end of experiment i.e on 22nd day hemodynamic, biochemical and histopathological study of heart tissue were evaluated from control and experimental groups. Isoproterenol treated animals showed significant increase in heart rate and cardiac biomarkers. Whereas, mean arterial blood pressure and antioxidant parameters were significantly decreased. Animals administered with different combinations of standardized extracts of Terminalia arjuna and Ocimum sanctum significantly maintained the levels of cardiac biomarkers, antioxidant parameters, mean arterial pressure and heart rate. Histopathology study showed marked myocardial necrosis in Isoproterenol treated animals and significant cardiac protection of animals treated with extract combinations. Hence, we may conclude that herb- herb combinations were found to be effective in prevention of myocardial injury induced by isoproterenol.
Keywords
Cardiac necrosis, Isoproterenol, Ocimum sanctum, Terminalia arjuna and Myocardial infarction
References
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- Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for Its in Vitro Antioxidant Activity
Abstract Views :98 |
PDF Views:0
Authors
Chetan Savant
1,
Venkatrao Kulkarni
1,
Preeti Kulkarni
1,
Prasanna Habbu
2,
Muhammed Majeed
3,
Mahadeva Nayak
3
Affiliations
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, IN
3 SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, IN
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, IN
3 SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 188-192Abstract
The present experiment was carried out with the aim to screen selected herb-drug for its antioxidant activity in combination and individually. The antioxidant activity of test samples were estimated by 2,2 Diphenyl -1-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay. All the selected herb-drug combinations have shown significant antioxidant activity in all three antioxidant procedures compared to individual herb or drug sample. Hence, it may be concluded that herb-drug combinations have better antioxidant potential than alone.Keywords
Tinospora cordifolia, Ocimum sanctum, Terminalia arjuna, Antioxidant activity, Atenolol, Propranolol and Amlodipine.References
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