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Thakurdesai, Prasad
- Effect of Ethanolic Extract of Leaves of Cocculus hirsutus (L.) Diels on Experimentally Induced Urothiliasis in Rats
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PDF Views:1199
Authors
Naimesh Patel
,
Sachin Badole
,
Pankaj Gupta
,
Brijendra Jain
,
Prasad Thakurdesai
,
Subodh Bhardwaj
,
Subhash Bodhankar
Source
Journal of Natural Remedies, Vol 8, No 1 (2008), Pagination: 24-31Abstract
In the present study, we report anti-urolithiasis effect of ethanolic extract of leaves of Cocculus hirsutus (L.) Diels (CH-eth) on the biochemical and histopathological parameters against sodium oxalate (NaOx) induced urolithiasis model in rat. The increased severity of microscopic calcium oxalate (CaOx) crystal deposition along with increased CaOx concentration in kidney was seen after seven days of NaOx (70 mg/kg, i.p) pretreatment. CH-eth (100 and 200 mg/kg, p.o.) and standard marketed formulation, Cystone® (500 mg/kg, p.o.) caused significant reversal of NaOx induced changes in ion excretion and urinary CaOx concentration in seven day treatement (prophylactic and therapeutic schedule). In conclusion, CH-eth showed beneficial effect against urolithiasis by decreasing CaOx excretion and preventing crystal deposition in kidney tubules.Keywords
Calcium Oxalate, Cocculus hirsutus, Urolithiasis, Nephrolithiasis, Sodium Oxalate- Preclinical Safety Assessment of Standardized Extract of Centella asiatica (L.) Urban Leaves
Abstract Views :192 |
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Authors
Affiliations
1 Department of Scientific Affairs, Indus Biotech Private Limited, Kondhwa, Pune, Maharashtra, IN
1 Department of Scientific Affairs, Indus Biotech Private Limited, Kondhwa, Pune, Maharashtra, IN