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Varpe, Prajkta
- Comparison Study of Conventional and Microwave Assisted Force Degradation by RP-HPLC Method of Pharmaceutical Drug and Dosage Form
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, IN
2 MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra State 422003, IN
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, IN
2 MET’s Institute of Pharmacy, MET League of Colleges, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra State 422003, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 7, No 4 (2017), Pagination: 218-224Abstract
Comparison Study of conventional and Microwave assisted Force Degradation by using RP- HPLC was carried for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron)RP- 18 column with a mobile phase consisting of Methanol: Water(20:80v/v) was used. Microwave assisted Force Degradation was performed acid, alkali, wet heat, oxidative and dry heat degradation study to prove that similar degradation product using microwave oven reduced time as compared to conventional. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.Keywords
RP-HPLC, Force Degradation, Microwave and Piracetam.
References
- V. Masarskal Analytical Method Development and Validation For Piracetam In Pharmaceutical Formulation Pharmacia, vol. 60, No. 4/2013
- Sushil D. Patil, Sunil V. Amurutkar and C. D. Upasani Development and Validation of Stability Indicating RP-HPLC Method for Empagliflozin Asian J. Pharm. Ana. 2016,Vol. 6; Issue 4
- Manutosh Acharya1, A.K Jain, et al RP-HPLC Method Development And Validation For Simultaneous Determination of Citicoline And Piracetam In Pharmaceutical Dosage Form Indo American Journal of Pharmaceutical Research, 2015, Vol 5, Issue 08, 3639-3647.
- Bhowmick Anindita A., Khandelwal, et al Analytical Method Development and Validation for Piracetam as Bulk and in Pharmaceutical Formulation International Journal of Pharm Tech Research.2010,Vol.2, No.1, pp 201-204
- Sonwane S.S et al Microwave Assisted forced degradation and development of a validated stability-indicating RP-HPLC method for Venlafaxine in bulk and capsule formulation Indian Drugs,2016,53(2),47-51
- International Conference on harmonization. Guideline on Validation of Analytical Procedure. Text and Methodology. ICH – Q2 (R1); 2005.
- Bakshi, Monika, and Saranjit Singh. "Development of Validated Stability-Indicating Assay Methods—Critical Review." Journal of Pharmaceutical and Biomedical Analysis 2002, 28.61011-40.
- Snyder L.R., Kirkland J. and Glajch J. (1997) Practical HPLC Method Development, 2nd ed. New York: John Wiley and Sons.
- Government of India, Indian Pharmacopoeia Commission Ministry of Health and Welfare (2007) Indian pharmacopoeia, Ghaziabad India
- Hong, Donald H., and Mumtaz Shah. "Development and Validation of HPLC Stability Indicating Assays." Drug Stability Principles and Practices. Ed. Christensen, Jens Thurø. 3 ed. New York: M. Dekker, 2002. 329-84.
- Q1BICH. "Photo stability Testing of New Drug Substances and Products Q1B." International Conference on Harmonization. Geneva: ICH, 1996.
- Q2 (R1)ICH. "Validation of Analytical Procedures: Text and Methodology Q2 (R1)."International Conference on Harmonization. Geneva: ICH, 2005.
- Development and Validation of Stability Indicating RP-HPLC Method for Piracetam
Abstract Views :479 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, IN
2 Savitribai Phule Pune University, Pune, Maharshtra state, IN
1 Department of Pharmaceutical Chemistry, MET's Institute of Pharmacy, Bhujbal Knowledge City, Adgaon Nashik, Maharashtra, IN
2 Savitribai Phule Pune University, Pune, Maharshtra state, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 4 (2017), Pagination: 215-221Abstract
A simple, rapid and validated HPLC method was developed for determination of Piracetam in film coated tablets. A Grace C18 (250mm x 4.6ID, Particle size: 5 micron) RP-18 column with a mobile phase consisting of Methanol: Water (20:80v/v) was used. Quantitative evaluation was performed at 205 nm. The HPLC method is selective, precise and accurate and can be used for routine analysis of preparations in pharmaceutical industry quality control laboratories.Keywords
RP-HPLC, Force Degradation Study, Piracetam.References
- V. Masarskal Analytical Method Development and Validation For Piracetam In Pharmaceutical Formulation Pharmacia, vol. 60, No. 4/2013
- Sushil D. Patil, Sunil V. Amurutkar and C. D. Upasani Development and Validation of Stability Indicating RP-HPLC Method for Empagliflozin Asian J. Pharm. Ana. 2016,Vol. 6; Issue 4
- Manutosh Acharya1, A.K Jain, et al RP-HPLC Method Development And Validation For Simultaneous Determination of Citicoline And Piracetam In Pharmaceutical Dosage Form Indo American Journal of Pharmaceutical Research, 2015, Vol 5, Issue 08, 3639-3647.
- Bhowmick Anindita A., Khandelwal, et al Analytical Method Development and Validation for Piracetam as Bulk and in Pharmaceutical Formulation International Journal of PharmTech Research.2010,Vol.2, No.1, pp 201-204,
- International Conference on harmonization. Guideline on Validation of Analytical Procedure. Text and Methodology. ICH – Q2 (R1); 2005.
- Bakshi, Monika, and Saranjit Singh. "Development of Validated Stability-Indicating Assay Methods—Critical Review." Journal of Pharmaceutical and Biomedical Analysis 2002, 28.61011-40.
- Snyder L.R., Kirkland J. and Glajch J. (1997) Practical HPLC Method Development, 2nd ed. New York: John Wiley and Sons.
- Government of India, Indian Pharmacopoeia Commission Ministry of Health and Welfare (2007) Indian Pharmacopoeia, Ghaziabad India
- Hong, Donald H., and Mumtaz Shah. "Development and Validation of HPLC Stability Indicating Assays." Drug Stability Principles and Practices. Ed. Christensen, Jens Thur. 3ed. New York: M. Dekker, 2002. 329-84.
- Q1BICH. "Photostability Testing of New Drug Substances and Products Q1B."International Conference on Harmonization. Geneva: ICH, 1996.
- Q2 (R1) ICH. "Validation of Analytical Procedures: Text and Methodology Q2 (R1)."International Conference on Harmonization. Geneva: ICH, 2005.