Informatics Publishing Limited

Sanjib Bahadur ¹, Amit Roy ¹, Ranabir Chanda ², Pragya Baghel ¹, Suman Saha ¹, Ananta Choudhury ¹

Affiliations
1 Columbia Institute of Pharmacy, Village Tekari, Near Vidhan Sabha, Raipur (CG), IN
2 Bengal School of Technology, Sugandha, Delhi Road, Hooghly, (W.B), IN

Abstract

Hibiscus rosasinensis (HR) is a shrub belonging to Malvaceae. The leaves of ethanolic extract of HR exhibited antidiabetic activity. Mucilage is present in leaves of HR. The objective of this research is to extract and evaluate the mucilage of HR. Leaves were collected and slurry was prepared which was precipitated using ethanol. The precipitates were separated and dried. The dried mucilage was subjected to various phytochemical and physicochemical tests. The extracted mucilage shows the presence of carbohydrates, reducing sugar and mucilage whereas glycoside, alkaloids, steroids, flavonoids and tannins was absent. The moisture sorption test reveals that the mucilage can sorbed moisture and has ability of swelling in water as shown by result of swelling index test. Other physicochemical studies indicate that the mucilage has properties to be used as excipient. FTIR spectrum shows the presence of various functional groups and bonds it possesses. It can be concluded that the mucilage can be used to prepare dosage form. However, as it can absorb moisture, the prepared dosage form should be packed suitably to avoid the contact of moisture.

Keywords

Efficacy, Safety, Lesser Side Effects, Memory Loss, Osteoporosis, Immune Disorders, Standardization.

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Pragya Baghel ¹, Amit Roy ², Shashikant Chandrakar ², Sanjib Bahadur ²

Affiliations
1 Columbia Institute of Pharmacy, Vil. Tekari, Near Vidhan Sabha, Raipur (C.G) 493 111, IN
2 Columbia Institute of Pharmacy, Vil. Tekari, Near Vidhan Sabha, Raipur (C.G) 493 111, IN

Abstract

Pulsatile drug delivery system is nowadays gaining a lot of interest as they deliver the drug at right site of action at the right time and in the right amount. These systems are designed according to the circadian rhythm of the body, and the drug is released rapidly and completely as a pulse after a lag time. Products follow the sigmoid release profile characterized by a time period. Theses follow chronopharmacological behavior, where nocturnal dosing is required, and for drugs that show the first-pass effect. Various systems like capsular system, osmotic system, and single multiple unit system based on the use of soluble or erodible polymer coating and use of rupturable membrane. Diseases where in PDDS are promising include asthma, peptic ulcers, cardiovascular ailments, arthritis and attention deficit syndrome in children and hypercholesterolemia.

Keywords

Pulsatile Drug Delivery, Chronopharmacology, Circadian Rhythm, Sigmoidal Release.

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