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R. Vadivelan ¹, S. P. Dhanabal ², Patil Mohan ², A. Shanish ², K. Elango ², B. Suresh ²

Affiliations
1 Department of Pharmacology, J.S.S. College of Pharmacy, (Off Campus of JSS University, Mysore), Ooty, Nilgiris - 643 001., IN
2 J.S.S. College of Pharmacy (Off Campus of JSS University, Mysore) Ooty, Nilgiris-643001, IN

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Though different types of oral hypoglycemic agents are available, there is a growing interest in herbal remedies due to effectiveness, minimal side effects in clinical experience and relatively low cost. We investigated effect of oral administration of 100 and 200 mg/kg of ethanolic extract of Mukia maderaspatana in diabetic and normal rats for hypoglycemic activity and antihypergylcemic activity. Diabetes was induced in male wistar albino rats of body weight 150-200 g by intraperitoneal administration of ice-cold aqueous alloxan monohydrate at dose of 150 mg/kg. Blood samples were collected for the measurement of blood glucose from the tail vein at 0, 1, 3, and 5 hr post treatment with plant extract. Glibenclamide was used as standard drug. The fasting blood glucose levels of diabetic untreated rats were significantly higher than those of normal. The ethanolic extracts of Mukia maderaspatana at 100 and 200 mg/kg showed 20% and 24.4% decrease in blood glucose level respectively in diabetic rats after 5 h of treatment. Treatment with glibenclamide at 0.2 g/kg dose level show 31.8% decrease in blood glucose level in diabetic rats. The present study revealed that the oral administration of ethanolic extracts at 100 and 200 mg/kg doses exhibited a significant antihyperglycemic activity in alloxan induced diabetes and also no hypoglycemic effect was observed in normal rats.

Keywords

Mukia maderaspatana, Alloxan Diabetic Rats, Antidiabetic Activity and Hypoglycemic Activity.

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